But in my opinion we can now be assured sufficiently that no animals, however small they may be, take their origin in putrefaction, but exclusively in procreation... For seeing that animals, from the largest down to the little despised animal, the flea, have animalcules in their semen, seeing also that some of the vessels of the lungs of horses and cows consist of rings and that these rings can occur on the flea's veins, why cannot we come to the conclusion that as well as the male sperm of that large animal the horse and similar animals, and of all manner of little animals, the flea included, is furnished with animalcules (and other intestines, for I have often been astonished when I beheld the numerous vessels in a flea), why, I say should not the male sperm of the smallest animals, smaller than a flea may even the very smallest animalcules have the perfection that we find in a flea.

The power of the eye could not be extended further in the opened living animal, hence 1 had believed that this body of the blood breaks into the empty space, and is collected again by a gaping vessel and by the structure of the walls. The tortuous and diffused motion of the blood in divers directions, and its union at a determinate place offered a handle to this. But the dried lung of the frog made my belief dubious. This lung had, by chance, preserved the redness of the blood in (what afterwards proved to be) the smallest vessels, where by means of a more perfect lens, no more there met the eye the points forming the skin called Sagrino, but vessels mingled annularly. And, so great is the divarication of these vessels as they go out, here from a vein, there from an artery, that order is no longer preserved, but a network appears made up of the prolongations of both vessels. This network occupies not only the whole floor, but extends also to the walls, and is attached to the outgoing vessel, as I could see with greater difficulty but more abundantly in the oblong lung of a tortoise, which is similarly membranous and transparent. Here it was clear to sense that the blood flows away through the tortuous vessels, that it is not poured into spaces but always works through tubules, and is dispersed by the multiplex winding of the vessels.

This is the right cavity of the two cavities of the heart. When the blood in this cavity has become thin, it must be transferred into the left cavity, where the pneuma is generated. But there is no passage between these two cavities, the substance of the heart there being impermeable. It neither contains a visible passage, as some people have thought, nor does it contain an invisible passage which would permit the passage of blood, as Galen thought. The pores of the heart there are compact and the substance of the heart is thick. It must, therefore, be that when the blood has become thin, it is passed into the arterial vein [pulmonary artery] to the lung, in order to be dispersed inside the substance of the lung, and to mix with the air. The finest parts of the blood are then strained, passing into the venous artery [pulmonary vein] reaching the left of the two cavities of the heart, after mixing with the air and becoming fit for the generation of pneuma.