I attained a triumph so complete that it is now rare to meet an American with marks of small pox on his face... Benefits are valuable according to their duration and extent, like the showers from heaven, but the benign remedy Vaccination saves millions of lives every century, like the blessing of the sun, universal and everlasting.
(Remark made near the end of his life.)

Whereas you have a very expensive dept. for destroying human life, would it not be for the honour of the New World to have a little national establishment for the preservation of human life; more especially as the devouring monster, small pox, has already destroyed many millions (some say 40) more lives than there are people now on the face of the earth.
(Conclusion of a letter (14 Dec 1826) to Massachusetts Congressman Edward Everett (1794-1865), in which he outlined his experience with vaccination.)