A process which led from the amoeba to man appeared to the philosophers to be obviously a progress -- though whether the amoeba would agree with this opinion is not known.

It may be observed of mathematicians that they only meddle with such things as are certain, passing by those that are doubtful and unknown. They profess not to know all things, neither do they affect to speak of all things. What they know to be true, and can make good by invincible arguments, that they publish and insert among their theorems. Of other things they are silent and pass no judgment at all, chusing [choosing] rather to acknowledge their ignorance, than affirm anything rashly. They affirm nothing among their arguments or assertions which is not most manifestly known and examined with utmost rigour, rejecting all probable conjectures and little witticisms. They submit nothing to authority, indulge no affection, detest subterfuges of words, and declare their sentiments, as in a Court of Judicature [Justice], without passion, without apology; knowing that their reasons, as Seneca testifies of them, are not brought to persuade, but to compel.

Modern science has been a voyage into the unknown, with a lesson in humility waiting at every stop. Many passengers would rather have stayed home.

Nomenclature, the other foundation of botany, should provide the names as soon as the classification is made... If the names are unknown knowledge of the things also perishes... For a single genus, a single name.

The man in the street will, therefore, twist the statement that the scientist has come to the end of meaning into the statement that the scientist has penetrated as far as he can with the tools at his command, and that there is something beyond the ken of the scientist. This imagined beyond, which the scientist has proved he cannot penetrate, will become the playground of the imagination of every mystic and dreamer. The existence of such a domain will be made the basis of an orgy of rationalizing. It will be made the substance of the soul; the spirits of the dead will populate it; God will lurk in its shadows; the principle of vital processes will have its seat here; and it will be the medium of telepathic communication. One group will find in the failure of the physical law of cause and effect the solution of the age-long problem of the freedom of the will; and on the other hand the atheist will find the justification of his contention that chance rules the universe.

The theory of probability is the only mathematical tool available to help map the unknown and the uncontrollable. It is fortunate that this tool, while tricky, is extraordinarily powerful and convenient.

What struck me most in England was the perception that only those works which have a practical tendency awake attention and command respect, while the purely scientific, which possess far greater merit are almost unknown. And yet the latter are the proper source from which the others flow. Practice alone can never lead to the discovery of a truth or a principle. In Germany it is quite the contrary. Here in the eyes of scientific men no value, or at least but a trifling one, is placed upon the practical results. The enrichment of science is alone considered worthy attention.

[No one will be able to] deter the scientific mind from probing into the unknown any more than Canute could command the tides.
Comment upon the U.S. Supreme Court's 1980 decision permitting the patenting of life forms.