At lunch Francis [Crick] winged into the Eagle to tell everyone within hearing distance that we had found the secret of life.

From my close observation of writers ... they fall in to two groups: 1) those who bleed copiously and visibly at any bad review, and 2) those who bleed copiously and secretly at any bad review.

God put a secret art into the forces of Nature so as to enable it to fashion itself out of chaos into a perfect world system.

Newton was not the first of the age of reason. He was the last of the magicians, the last of the Babylonians and Sumerians ... Isaac Newton, a posthumous child born with no father on Christmas Day, 1642, was the last wonder child to whom the Magi could do sincere and appropriate homage... Why do I call him a magician? Because he looked on the whole universe and all that is in it as a riddle, as a secret which could be read by applying pure thought to certain evidence, certain mystic clues which God had laid about the world to allow a sort of philosopher's treasure hunt to the esoteric brotherhood... He regarded the Universe as a cryptogram set by the Almighty—just as he himself wrapt the discovery of the calculus in a cryptogram when he communicated with Leibniz. By pure thought, by concentration of mind, the riddle, he believed, would be revealed to the initiate.

The most heated defenders of a science, who cannot endure the slightest sneer at it, are commonly those who have not made very much progress in it and are secretly aware of this defect.

The open secret of real success is to throw your whole personality into your problem.

The secrets of evolution are death and time—the deaths of enormous numbers of lifeforms that were imperfectly adapted to the environment; and time for a long succession of small mutations.

The year that Rutherford died (1938 [sic]) there disappeared forever the happy days of free scientific work which gave us such delight in our youth. Science has lost her freedom. Science has become a productive force. She has become rich but she has become enslaved and part of her is veiled in secrecy. I do not know whether Rutherford would continue to joke and laugh as he used to.

What is a scientist?… We give the name scientist to the type of man who has felt experiment to be a means guiding him to search out the deep truth of life, to lift a veil from its fascinating secrets, and who, in this pursuit, has felt arising within him a love for the mysteries of nature, so passionate as to annihilate the thought of himself.

What's the best part of being a mathematician? I'm not a religious man, but it's almost like being in touch with God when you're thinking about mathematics. God is keeping secrets from us, and it's fun to try to learn some of the secrets.

While Newton seemed to draw off the veil from some of the mysteries of nature, he showed at the same time the imperfections of the mechanical philosophy; and thereby restored her ultimate secrets to that obscurity, in which they ever did and ever will remain.