All appearances to the contrary, the only watchmaker in nature is the blind forces of physics, albeit deployed in very special way. A true watchmaker has foresight: he designs his cogs springs, and plans their interconnections, with a future purpose in his mind's eye. Natural selection, the blind, unconscious, automatic process which Darwin discovered, and which we now know is the explanation for the existence and apparently purposeful form of all life, has no purpose in mind. It has no mind and no mind's eye. It does not plan for the future. It has no vision, no foresight, no sight at all. If it can be said to play the role of watchmaker in nature, it is the blind watchmaker.

Almost every major systematic error which has deluded men for thousands of years relied on practical experience. Horoscopes, incantations, oracles, magic, witchcraft, the cures of witch doctors and of medical practitioners before the advent of modern medicine, were all firmly established through the centuries in the eyes of the public by their supposed practical successes. The scientific method was devised precisely for the purpose of elucidating the nature of things under more carefully controlled conditions and by more rigorous criteria than are present in the situations created by practical problems.

And I believe there are many Species in Nature, which were never yet taken notice of by Man, and consequently of no use to him, which yet we are not to think were created in vain; but it's likely ... to partake of the overflowing Goodness of the Creator, and enjoy their own Beings. But though in this sense it be not true, that all things were made for Man; yet thus far it is, that all the Creatures in the World may be some way or other useful to us, at least to exercise our Wits and Understandings, in considering and contemplating of them, and so afford us Subject of Admiring and Glorifying their and our Maker. Seeing them, we do believe and assert that all things were in some sense made for us, we are thereby obliged to make use of them for those purposes for which they serve us, else we frustrate this End of their Creation.

Are God and Nature then at strife,
That Nature lends such evil dreams?
So careful of the type she seems,
So careless of the single life; ...
'So careful of the type', but no.
From scarped cliff and quarried stone
She cries, 'A thousand types are gone:
I care for nothing, all shall go' ...
Man, her last work, who seemed so fair,
Such splendid purpose in his eyes,
Who rolled the psalm to wintry skies,
Who built him fanes of fruitless prayer,
Who trusted God was love indeed
And love Creation's final law—
Tho’ Nature red in tooth and claw
With ravine, shrieked against his creed...

Bohr's standpoint, that a space-time description is impossible, I reject a limine. Physics does not consist only of atomic research, science does not consist only of physics, and life does not consist only of science. The aim of atomic research is to fit our empirical knowledge concerning it into our other thinking. All of this other thinking, so far as it concerns the outer world, is active in space and time. If it cannot be fitted into space and time, then it fails in its whole aim and one does not know what purpose it really serves.

But I don't have to know an answer. I don't feel frightened by not knowing things, by being lost in a mysterious universe within any purpose, which is the way it really is, so far as I can tell. It doesn't frighten me.

But I think that in the repeated and almost entire changes of organic types in the successive formations of the earth—in the absence of mammalia in the older, and their very rare appearance (and then in forms entirely. unknown to us) in the newer secondary groups—in the diffusion of warm-blooded quadrupeds (frequently of unknown genera) through the older tertiary systems—in their great abundance (and frequently of known genera) in the upper portions of the same series—and, lastly, in the recent appearance of man on the surface of the earth (now universally admitted—in one word, from all these facts combined, we have a series of proofs the most emphatic and convincing,—that the existing order of nature is not the last of an uninterrupted succession of mere physical events derived from laws now in daily operation: but on the contrary, that the approach to the present system of things has been gradual, and that there has been a progressive development of organic structure subservient to the purposes of life.

Do we really wish to replace the fateful but impartial workings of chance with the purposeful self-interested workings of human will?
Reported in 1981, expressing concern for the future of gene-splicing.

Doctor, no medicine.—We are machines made to live—organized expressly for that purpose.—Such is our nature.—Do not counteract the living principle.—Leave it at liberty to defend itself, and it will do better than your drugs.

Every physical fact, every expression of nature, every feature of the earth, the work of any and all of those agents which make the face of the world what it is, and as we see it, is interesting and instructive. Until we get hold of a group of physical facts, we do not know what practical bearings they may have, though right-minded men know that they contain many precious jewels, which science, or the expert hand of philosophy will not fail top bring out, polished, and bright, and beautifully adapted to man's purposes.

For me, the idea of a creation is not conceivable without invoking the necessity of design. One cannot be exposed to the law and order of the universe without concluding that there must be design and purpose behind it all.

Freud expressed the opinion—not quite in earnest, though, it seeemed to me—that philosophy was the most decent form of sublimation of repressed sexuality, nothing more. In response I put the question, 'What then is science, particularly psychoanalytic psychology?' Whereup on he, visible a bit surprised, answered evasively: 'At least psychology has a social purpose.'

I do not conceive of any manifestation of culture, of science, of art, as purposes in themselves. I think the purpose of science and culture is man.

I have been asked whether I would agree that the tragedy of the scientist is that he is able to bring about great advances in our knowledge, which mankind may then proceed to use for purposes of destruction. My answer is that this is not the tragedy of the scientist; it is the tragedy of mankind.

I look upon statistics as the handmaid of medicine, but on that very account I hold that it befits medicine to treat her handmaid with proper respect, and not to prostitute her services for controversial or personal purposes.

I work for perfection, for perfection's sake. I don't care what the external reasons are. And it's much more like a ballerina on opening night. You've done what you've got to do. When you go out, the purpose is to turn a perfect turn. You are not thinking about the future of the company, you are not thinking about your future, you're not thinking about the critics, it is you and the perfect turn.
[Describing his task of repairing the Hubble Space Telescope.]

In order that the facts obtained by observation and experiment may be capable of being used in furtherance of our exact and solid knowledge, they must be apprehended and analysed according to some Conceptions which, applied for this purpose, give distinct and definite results, such as can be steadily taken hold of and reasoned from.

In the temple of science are many mansions, and various indeed are they that dwell therein and the motives that have led them thither. Many take to science out of a joyful sense of superior intellectual power; science is their own special sport to which they look for vivid experience and the satisfaction of ambition; many others are to be found in the temple who have offered the products of their brains on this altar for purely utilitarian purposes. Were an angel of the Lord to come and drive all the people belonging to these two categories out of the temple, the assemblage would be seriously depleted, but there would still be some men, of both present and past times, left inside. Our Planck is one of them, and that is why we love him.

Inanimate objects are classified scientifically into three categories—those that don't work, those that break down, and those that get lost. The goal of all inanimate objects is to resist man and ultimately to defeat him, and the three major classifications are based on the method each object uses to achieve its purpose

Indeed, not all attacks—especially the bitter and ridiculing kind leveled at Darwin—are offered in good faith, but for practical purposes it is good policy to assume that they are.

Indeed, we need not look back half a century to times which many now living remember well, and see the wonderful advances in the sciences and arts which have been made within that period. Some of these have rendered the elements themselves subservient to the purposes of man, have harnessed them to the yoke of his labors and effected the great blessings of moderating his own, of accomplishing what was beyond his feeble force, and extending the comforts of life to a much enlarged circle, to those who had before known its necessaries only.

Inexact method of observation, as I believe, is one flaw in clinical pathology to-day. Prematurity of conclusion is another, and in part follows from the first; but in chief part an unusual craving and veneration for hypothesis, which besets the minds of most medical men, is responsible. Except in those sciences which deal with the intangible or with events of long past ages, no treatises are to be found in which hypothesis figures as it does in medical writings. The purity of a science is to be judged by the paucity of its recorded hypotheses. Hypothesis has its right place, it forms a working basis; but it is an acknowledged makeshift, and, at the best, of purpose unaccomplished. Hypothesis is the heart which no man with right purpose wears willingly upon his sleeve. He who vaunts his lady love, ere yet she is won, is apt to display himself as frivolous or his lady a wanton.

It is often claimed that knowledge multiplies so rapidly that nobody can follow it. I believe this is incorrect. At least in science it is not true. The main purpose of science is simplicity and as we understand more things, everything is becoming simpler. This, of course, goes contrary to what everyone accepts.

It is very desirable to have a word to express the Availability for work of the heat in a given magazine; a term for that possession, the waste of which is called Dissipation. Unfortunately the excellent word Entropy, which Clausius has introduced in this connexion, is applied by him to the negative of the idea we most naturally wish to express. It would only confuse the student if we were to endeavour to invent another term for our purpose. But the necessity for some such term will be obvious from the beautiful examples which follow. And we take the liberty of using the term Entropy in this altered sense ... The entropy of the universe tends continually to zero.

Knowing the plumbing of the universe, intricate and awe-inspiring though that plumbing might be, is a far cry from discovering its purpose.

Man has risen, not fallen. He can choose to develop his capacities as the highest animal and to try to rise still farther, or he can choose otherwise. The choice is his responsibility, and his alone. There is no automatism that will carry him upward without choice or effort and there is no trend solely in the right direction. Evolution has no purpose; man must supply this for himself. The means to gaining right ends involve both organic evolution and human evolution, but human choice as to what are the right ends must be based on human evolution.

One of the main purposes of scientific inference is to justify beliefs which we entertain already; but as a rule they are justified with a difference. Our pre-scientific general beliefs are hardly ever without exceptions; in science, a law with exceptions can only be tolerated as a makeshift. Scientific laws, when we have reason to think them accurate, are different in form from the common-sense rules which have exceptions: they are always, at least in physics, either differential equations, or statistical averages. It might be thought that a statistical average is not very different from a rule with exceptions, but this would be a mistake. Statistics, ideally, are accurate laws about large groups; they differ from other laws only in being about groups, not about individuals. Statistical laws are inferred by induction from particular statistics, just as other laws are inferred from particular single occurrences.

One should not understand this compulsion to construct concepts, species, forms, purposes, laws ('a world of identical cases') as if they enabled us to fix the real world; but as a compulsion to arrange a world for ourselves in which our existence is made possible:—we thereby create a world which is calculable, simplified, comprehensible, etc., for us.

Our contemporary culture, primed by population growth and driven by technology, has created problems of environmental degradation that directly affect all of our senses: noise, odors and toxins which bring physical pain and suffering, and ugliness, barrenness, and homogeneity of experience which bring emotional and psychological suffering and emptiness. In short, we are jeopardizing our human qualities by pursuing technology as an end rather than a means. Too often we have failed to ask two necessary questions: First, what human purpose will a given technology or development serve? Second, what human and environmental effects will it have?

Research is formalized curiosity. It is poking and prying with a purpose.

Science and art, or by the same token, poetry and prose differ from one another like a journey and an excursion. The purpose of the journey is its goal, the purpose of an excursion is the process.

Science moves, but slowly, slowly, creeping on from point to point. ...
Yet I doubt not through the ages one increasing purpose runs,
And the thoughts of men are widened with the process of the suns. ...
Knowledge comes, but wisdom lingers.

Science, then, is the attentive consideration of common experience; it is common knowledge extended and refined. Its validity is of the same order as that of ordinary perception; memory, and understanding. Its test is found, like theirs, in actual intuition, which sometimes consists in perception and sometimes in intent. The flight of science is merely longer from perception to perception, and its deduction more accurate of meaning from meaning and purpose from purpose. It generates in the mind, for each vulgar observation, a whole brood of suggestions, hypotheses, and inferences. The sciences bestow, as is right and fitting, infinite pains upon that experience which in their absence would drift by unchallenged or misunderstood. They take note, infer, and prophesy. They compare prophesy with event, and altogether they supply—so intent are they on reality—every imaginable background and extension for the present dream.

Scientific discovery and scientific knowledge have been achieved only by those who have gone in pursuit of them without any practical purpose whatsoever in view.

The illusion of purpose and design is perhaps the most pervasive illusion about nature that science has to confront on a daily basis. Everywhere we look, it appears that the world was designed so that we could flourish.

The life and soul of science is its practical application, and just as the great advances in mathematics have been made through the desire of discovering the solution of problems which were of a highly practical kind in mathematical science, so in physical science many of the greatest advances that have been made from the beginning of the world to the present time have been made in the earnest desire to turn the knowledge of the properties of matter to some purpose useful to mankind.

The main purpose of a significance test is to inhibit the natural enthusiasm of the investigator.

The Mathematics, I say, which effectually exercises, not vainly deludes or vexatiously torments studious Minds with obscure Subtilties, perplexed Difficulties, or contentious Disquisitions; which overcomes without Opposition, triumphs without Pomp, compels without Force, and rules absolutely without Loss of Liberty; which does not privately over-reach a weak Faith, but openly assaults an armed Reason, obtains a total Victory, and puts on inevitable Chains; whose Words are so many Oracles, and Works as many Miracles; which blabs out nothing rashly, nor designs anything from the Purpose, but plainly demonstrates and readily performs all Things within its Verge; which obtrudes no false Shadow of Science, but the very Science itself, the Mind firmly adhering to it, as soon as possessed of it, and can never after desert it of its own Accord, or be deprived of it by any Force of others: Lastly the Mathematics, which depends upon Principles clear to the Mind, and agreeable to Experience; which draws certain Conclusions, instructs by profitable Rules, unfolds pleasant Questions; and produces wonderful Effects; which is the fruitful Parent of, I had almost said all, Arts, the unshaken Foundation of Sciences, and the plentiful Fountain of Advantage to human Affairs.

The origin of an adaptive structure and the purposes it comes to fulfill are only chance combinations. Purposefulness is a very human conception for usefulness. It is usefulness looked at backwards. Hard as it is to imagine, inconceivably hard it may appear to many, that there is no direct relation between the origin of useful variations and the ends they come to serve, yet the modern zoologist takes his stand as a man of science on this ground. He may admit in secret to his father confessor, the metaphysician, that his poor intellect staggers under such a supposition, but he bravely carries forward his work of investigation along the only lines that he has found fruitful.

The origin of an adaptive structure and the purposes it comes to fulfill are only chance combinations. Purposefulness is a very human conception for usefulness. It is usefulness looked at backwards. Hard as it is to imagine, inconceivably hard it may appear to many, that there is no direct relation between the origin of useful variations and the ends they come to serve, yet the modern zoologist takes his stand as a man of science on this ground. He may admit in secret to his father confessor, the metaphysician, that his poor intellect staggers under such a supposition, but he bravely carries forward his work of investigation along the only lines that he has found fruitful.

The pre-Darwinian age had come to be regarded as a Dark Age in which men still believed that the book of Genesis was a standard scientific treatise, and that the only additions to it were Galileo's demonstration of Leonardo da Vinci's simple remark that the earth is a moon of the sun, Newton's theory of gravitation, Sir Humphry Davy's invention of the safety-lamp, the discovery of electricity, the application of steam to industrial purposes, and the penny post.

The purpose of models is not to fit the data but to sharpen the questions.

The traditional boundaries between various fields of science are rapidly disappearing and what is more important science does not know any national borders. The scientists of the world are forming an invisible network with a very free flow of scientific information - a freedom accepted by the countries of the world irrespective of political systems or religions. ... Great care must be taken that the scientific network is utilized only for scientific purposes - if it gets involved in political questions it loses its special status and utility as a nonpolitical force for development.

The truth us that other systems of geometry are possible, yet after all, these other systems are not spaces but other methods of space measurements. There is one space only, though we may conceive of many different manifolds, which are contrivances or ideal constructions invented for the purpose of determining space.

There are those who say that the human kidney was created to keep the blood pure, or more precisely, to keep our internal environment in an ideal balanced state. This I must deny. I grant that the human kidney is a marvelous organ, but I cannot grant that it was purposefully designed to excrete urine or to regulate the composition of the blood or to subserve the physiological welfare of Homo sapiens in any sense. Rather I contend that the human kidney manufactures the kind of urine that it does, and it maintains the blood in the composition which that fluid has, because this kidney has a certain functional architecture; and it owes that architecture not to design or foresight or to any plan, but to the fact that the earth is an unstable sphere with a fragile crust, to the geologic revolutions that for six hundred million years have raised and lowered continents and seas, to the predacious enemies, and heat and cold, and storms and droughts; to the unending succession of vicissitudes that have driven the mutant vertebrates from sea into fresh water, into desiccated swamps, out upon the dry land, from one habitation to another, perpetually in search of the free and independent life, perpetually failing, for one reason or another, to find it.

There are, I believe, very few maxims in philosophy that have laid firmer hold upon the mind, than that air, meaning atmospherical air (free from various foreign matters, which were always supposed to be dissolved, and intermixed with it) is a simple elementary substance, indestructible, and unalterable, at least as much so as water is supposed to be. In the course of my enquiries, I was, however, soon satisfied that atmospherical air is not an unalterable thing; for that the phlogiston with which it becomes loaded from bodies burning in it, and animals breathing it, and various other chemical processes, so far alters and depraves it, as to render it altogether unfit for inflammation, respiration, and other purposes to which it is subservient; and I had discovered that agitation in water, the process of vegetation, and probably other natural processes, by taking out the superfluous phlogiston, restore it to its original purity.

There cannot be design without a designer; contrivance without a contriver; order without choice; arrangement, without any thing capable of arranging; subserviency and relation to a purpose; means suitable to an end, and executing their office in accomplishing that end, without the end ever having been contemplated, or the means accommodated to it. Arrangement, disposition of parts, subserviency of means to an end, relation of instruments to use, imply the preference of intelligence and mind.

There is, it appears, a conspiracy of scientists afoot. Their purpose is to break down religion, propagate immorality, and so reduce mankind to the level of brutes. They are the sworn and sinister agents of Beelzebub, who yearns to conquer the world, and has his eye especially upon Tennessee.
[Report on the Scopes Monkey Trial.]

To the north [of Armenia] lies Zorzania [Georgia], near the confines of which there is a fountain of oil which discharges so great a quantity as to furnish loading for many camels. The use made of it is not for the purpose of food, but as an unguent for the cure of cutaneous distempers in men and cattle, as well as other complaints, and it is also good for burning. In the surrounding country no other [oil] is used in their lamps, and people come from distant parts to procure it.
[An early Western report of petroleum seepage. He visited the city of Baku, Azerbaijan in 1264.]

To understand God's thoughts one must study statistics ... the measure of his purpose.

We are machines built by DNA whose purpose is to make more copies of the same DNA. ... This is exactly what we are for. We are machines for propagating DNA, and the propagation of DNA is a self-sustaining process. It is every living object's sole reason for living.

We do not ask for what useful purpose the birds do sing, for song is their pleasure since they were created for singing. Similarly, we ought not to ask why the human mind troubles to fathom the secrets of the heavens ... The diversity of the phenomena of Nature is so great, and the treasures hidden in the heavens so rich, precisely in order that the human mind shall never be lacking in fresh nourishment.

We've been fighting from the beginning for organic architecture. That is, architecture where the whole is to the part as the part is to the whole, and where the nature of materials, the nature of the purpose, the nature of the entire performance becomes a necessity—architecture of democracy.

When... the biologist is confronted with the fact that in the organism the parts are so adapted to each other as to give rise to a harmonious whole; and that the organisms are endowed with structures and instincts calculated to prolong their life and perpetuate their race, doubts as to the adequacy of a purely physiochemical viewpoint in biology may arise. The difficulties besetting the biologist in this problem have been rather increased than diminished by the discovery of Mendelian heredity, according to which each character is transmitted independently of any other character. Since the number of Mendelian characters in each organism is large, the possibility must be faced that the organism is merely a mosaic of independent hereditary characters. If this be the case the question arises: What moulds these independent characters into a harmonious whole? The vitalist settles this question by assuming the existence of a pre-established design for each organism and of a guiding 'force' or 'principle' which directs the working out of this design. Such assumptions remove the problem of accounting for the harmonious character of the organism from the field of physics or chemistry. The theory of natural selection invokes neither design nor purpose, but it is incomplete since it disregards the physiochemical constitution of living matter about which little was known until recently.

Where should I start? Start from the statement of the problem. ... What can I do? Visualize the problem as a whole as clearly and as vividly as you can. ... What can I gain by doing so? You should understand the problem, familiarize yourself with it, impress its purpose on your mind.

You can be a thorough-going Neo-Darwinian without imagination, metaphysics, poetry, conscience, or decency. For 'Natural Selection' has no moral significance: it deals with that part of evolution which has no purpose, no intelligence, and might more appropriately be called accidental selection, or better still, Unnatural Selection, since nothing is more unnatural than an accident. If it could be proved that the whole universe had been produced by such Selection, only fools and rascals could bear to live.

[Young] was afterwards accustomed to say, that at no period of his life was he particularly fond of repeating experiments, or even of very frequently attempting to originate new ones; considering that, however necessary to the advancement of science, they demanded a great sacrifice of time, and that when the fact was once established, that time was better employed in considering the purposes to which it might be applied, or the principles which it might tend to elucidate.