All appearances to the contrary, the only watchmaker in nature is the blind forces of physics, albeit deployed in very special way. A true watchmaker has foresight: he designs his cogs springs, and plans their interconnections, with a future purpose in his mind's eye. Natural selection, the blind, unconscious, automatic process which Darwin discovered, and which we now know is the explanation for the existence and apparently purposeful form of all life, has no purpose in mind. It has no mind and no mind's eye. It does not plan for the future. It has no vision, no foresight, no sight at all. If it can be said to play the role of watchmaker in nature, it is the blind watchmaker.

Do we really wish to replace the fateful but impartial workings of chance with the purposeful self-interested workings of human will?
Reported in 1981, expressing concern for the future of gene-splicing.

Freud expressed the opinion—not quite in earnest, though, it seeemed to me—that philosophy was the most decent form of sublimation of repressed sexuality, nothing more. In response I put the question, 'What then is science, particularly psychoanalytic psychology?' Whereup on he, visible a bit surprised, answered evasively: 'At least psychology has a social purpose.'

Inanimate objects are classified scientifically into three categories—those that don't work, those that break down, and those that get lost. The goal of all inanimate objects is to resist man and ultimately to defeat him, and the three major classifications are based on the method each object uses to achieve its purpose

Indeed, not all attacks—especially the bitter and ridiculing kind leveled at Darwin—are offered in good faith, but for practical purposes it is good policy to assume that they are.

Inexact method of observation, as I believe, is one flaw in clinical pathology to-day. Prematurity of conclusion is another, and in part follows from the first; but in chief part an unusual craving and veneration for hypothesis, which besets the minds of most medical men, is responsible. Except in those sciences which deal with the intangible or with events of long past ages, no treatises are to be found in which hypothesis figures as it does in medical writings. The purity of a science is to be judged by the paucity of its recorded hypotheses. Hypothesis has its right place, it forms a working basis; but it is an acknowledged makeshift, and, at the best, of purpose unaccomplished. Hypothesis is the heart which no man with right purpose wears willingly upon his sleeve. He who vaunts his lady love, ere yet she is won, is apt to display himself as frivolous or his lady a wanton.

Research is formalized curiosity. It is poking and prying with a purpose.

Science and art, or by the same token, poetry and prose differ from one another like a journey and an excursion. The purpose of the journey is its goal, the purpose of an excursion is the process.

Scientific discovery and scientific knowledge have been achieved only by those who have gone in pursuit of them without any practical purpose whatsoever in view.

The life and soul of science is its practical application, and just as the great advances in mathematics have been made through the desire of discovering the solution of problems which were of a highly practical kind in mathematical science, so in physical science many of the greatest advances that have been made from the beginning of the world to the present time have been made in the earnest desire to turn the knowledge of the properties of matter to some purpose useful to mankind.

The Mathematics, I say, which effectually exercises, not vainly deludes or vexatiously torments studious Minds with obscure Subtilties, perplexed Difficulties, or contentious Disquisitions; which overcomes without Opposition, triumphs without Pomp, compels without Force, and rules absolutely without Loss of Liberty; which does not privately over-reach a weak Faith, but openly assaults an armed Reason, obtains a total Victory, and puts on inevitable Chains; whose Words are so many Oracles, and Works as many Miracles; which blabs out nothing rashly, nor designs anything from the Purpose, but plainly demonstrates and readily performs all Things within its Verge; which obtrudes no false Shadow of Science, but the very Science itself, the Mind firmly adhering to it, as soon as possessed of it, and can never after desert it of its own Accord, or be deprived of it by any Force of others: Lastly the Mathematics, which depends upon Principles clear to the Mind, and agreeable to Experience; which draws certain Conclusions, instructs by profitable Rules, unfolds pleasant Questions; and produces wonderful Effects; which is the fruitful Parent of, I had almost said all, Arts, the unshaken Foundation of Sciences, and the plentiful Fountain of Advantage to human Affairs.

The truth us that other systems of geometry are possible, yet after all, these other systems are not spaces but other methods of space measurements. There is one space only, though we may conceive of many different manifolds, which are contrivances or ideal constructions invented for the purpose of determining space.

To understand God's thoughts one must study statistics ... the measure of his purpose.

When... the biologist is confronted with the fact that in the organism the parts are so adapted to each other as to give rise to a harmonious whole; and that the organisms are endowed with structures and instincts calculated to prolong their life and perpetuate their race, doubts as to the adequacy of a purely physiochemical viewpoint in biology may arise. The difficulties besetting the biologist in this problem have been rather increased than diminished by the discovery of Mendelian heredity, according to which each character is transmitted independently of any other character. Since the number of Mendelian characters in each organism is large, the possibility must be faced that the organism is merely a mosaic of independent hereditary characters. If this be the case the question arises: What moulds these independent characters into a harmonious whole? The vitalist settles this question by assuming the existence of a pre-established design for each organism and of a guiding 'force' or 'principle' which directs the working out of this design. Such assumptions remove the problem of accounting for the harmonious character of the organism from the field of physics or chemistry. The theory of natural selection invokes neither design nor purpose, but it is incomplete since it disregards the physiochemical constitution of living matter about which little was known until recently.

Where should I start? Start from the statement of the problem. ... What can I do? Visualize the problem as a whole as clearly and as vividly as you can. ... What can I gain by doing so? You should understand the problem, familiarize yourself with it, impress its purpose on your mind.