A small bubble of air remained unabsorbed... if there is any part of the phlogisticated air [nitrogen] of our atmosphere which differs from the rest, and cannot be reduced to nitrous acid, we may safely conclude that it is not more than 1/120 part of the whole.
Cavendish did not realize the significance of the remaining small bubble. Not until a century later were the air’s Noble Gases appreciated.

Borel makes the amusing supposition of a million monkeys allowed to play upon the keys of a million typewriters. What is the chance that this wanton activity should reproduce exactly all of the volumes which are contained in the library of the British Museum? It certainly is not a large chance, but it may be roughly calculated, and proves in fact to be considerably larger than the chance that a mixture of oxygen and nitrogen will separate into the two pure constituents. After we have learned to estimate such minute chances, and after we have overcome our fear of numbers which are very much larger or very much smaller than those ordinarily employed, we might proceed to calculate the chance of still more extraordinary occurrences, and even have the boldness to regard the living cell as a result of random arrangement and rearrangement of its atoms. However, we cannot but feel that this would be carrying extrapolation too far. This feeling is due not merely to a recognition of the enormous complexity of living tissue but to the conviction that the whole trend of life, the whole process of building up more and more diverse and complex structures, which we call evolution, is the very opposite of that which we might expect from the laws of chance.

England and all civilised nations stand in deadly peril of not having enough to eat. As mouths multiply, food resources dwindle. Land is a limited quantity, and the land that will grow wheat is absolutely dependent on difficult and capricious natural phenomena... I hope to point a way out of the colossal dilemma. It is the chemist who must come to the rescue of the threatened communities. It is through the laboratory that starvation may ultimately be turned into plenty... The fixation of atmospheric nitrogen is one of the great discoveries, awaiting the genius of chemists.

Food may be defined as material which, when taken into the body, serves to either form tissue or yield energy, or both. This definition includes all the ordinary food materials, since they both build tissue and yield energy. It includes sugar and starch, because they yield energy and form fatty tissue. It includes alcohol, because the latter is burned to yield energy, though it does not build tissue. It excludes creatin, creatininin, and other so-called nitrogeneous extractives of meat, and likewise thein or caffein of tea and coffee, because they neither build tissue nor yield energy, although they may, at times, be useful aids to nutrition.

Our conception of a native protein molecule (showing specific properties) is the following. The molecule consists of one polypeptide chain which continues without interruption throughout the molecule (or, in certain cases, of two or more such chains); this chain is folded into a uniquely defined configuration, in which it is held by hydrogen bonds between the peptide nitrogen and oxygen atoms and also between the free amino and carboxyl groups of the diamino and dicarboxyl amino acid residues.
The characteristic specific properties of native proteins we attribute to their uniquely defined configurations.
The denatured protein molecule we consider to be characterized by the absence of a uniquely defined configuration.
[Co-author with American chemist, Linus Pauling (1901-94)]

The more important fundamental laws and facts of physical science have all been discovered, and these are now so firmly established that the possibility of their ever being supplanted in consequence of new discoveries is exceedingly remote. Nevertheless, it has been found that there are apparent exceptions to most of these laws, and this is particularly true when the observations are pushed to a limit, i.e., whenever the circumstances of experiment are such that extreme cases can be examined. Such examination almost surely leads, not to the overthrow of the law, but to the discovery of other facts and laws whose action produces the apparent exceptions. As instances of such discoveries, which are in most cases due to the increasing order of accuracy made possible by improvements in measuring instruments, may be mentioned: first, the departure of actual gases from the simple laws of the so-called perfect gas, one of the practical results being the liquefaction of air and all known gases; second, the discovery of the velocity of light by astronomical means, depending on the accuracy of telescopes and of astronomical clocks; third, the determination of distances of stars and the orbits of double stars, which depend on measurements of the order of accuracy of one-tenth of a second-an angle which may be represented as that which a pin's head subtends at a distance of a mile. But perhaps the most striking of such instances are the discovery of a new planet or observations of the small irregularities noticed by Leverrier in the motions of the planet Uranus, and the more recent brilliant discovery by Lord Rayleigh of a new element in the atmosphere through the minute but unexplained anomalies found in weighing a given volume of nitrogen. Many other instances might be cited, but these will suffice to justify the statement that 'our future discoveries must be looked for in the sixth place of decimals'.

When the state is shaken to its foundations by internal or external events, when commerce, industry and all trades shall be at a stand, and perhaps on the brink of ruin; when the property and fortune of all are shaken or changed, and the inhabitants of towns look forward with dread and apprehension to the future, then the agriculturalist holds in his hand the key to the money chest of the rich, and the savings-box of the poor; for political events have not the slightest influence on the natural law, which forces man to take into his system, daily, a certain number of ounces of carbon and nitrogen.
Reflecting on events of 1848.