Don't hesitate to be as revolutionary as science. Don't hesitate to be as reactionary as the multiplication table.

I never could do anything with figures, never had any talent for mathematics, never accomplished anything in my efforts at that rugged study, and to-day the only mathematics I know is multiplication, and the minute I get away up in that, as soon as I reach nine times seven— [He lapsed into deep thought, trying to figure nine times seven. Mr. McKelway whispered the answer to him.] I've got it now. It's eighty-four. Well, I can get that far all right with a little hesitation. After that I am uncertain, and I can't manage a statistic.

Thus you may multiply each stone 4 times & no more for they will then become oyles shining in ye dark and fit for magicall uses. You may ferment them with ☉ [gold] and [silver], by keeping the stone and metal in fusion together for a day, & then project upon metalls. This is the multiplication of ye stone in vertue. To multiply it in weight ad to it of ye first Gold whether philosophic or vulgar.

We do not know of any enzymes or other chemical defined organic substances having specifically acting auto-catalytic properties such as to enable them to construct replicas of themselves. Neither was there a general principle known that would result in pattern-copying; if there were, the basis of life would be easier to come by. Moreover, there was no evidence to show that the enzymes were not products of hereditary determiners or genes, rather than these genes themselves, and they might even be products removed by several or many steps from the genes, just as many other known substances in the cell must be. However, the determiners or genes themselves must conduct, or at least guide, their own replication, so as to lead to the formation of genes just like themselves, in such wise that even their own mutations become .incorporated in the replicas. And this would probably take place by some kind of copying of pattern similar to that postulated by Troland for the enzymes, but requiring some distinctive chemical structure to make it possible. By virtue of this ability of theirs to replicate, these genes–or, if you prefer, genetic material–contained in the nuclear chromosomes and in whatever other portion of the cell manifests this property, such as the chloroplastids of plants, must form the basis of all the complexities of living matter that have arisen subsequent to their own appearance on the scene, in the whole course of biological evolution. That is, this genetic material must underlie all evolution based on mutation and selective multiplication.