But as my conclusions have lately been much misrepresented, and it has been stated that I attribute the modification of species exclusively to natural selection, I may be permitted to remark that in the first edition of this work, and subsequently, I placed in a most conspicuous position—namely, at the close of the Introduction—the following words: 'I am convinced that natural selection has been the main but not the exclusive means of modification.' This has been of no avail. Great is the power of steady misrepresentation; but the history of science shows that fortunately this power does not long endure.

If you can modify a cell, it's only a short step to modifying a mouse, and if you can modify a mouse, it's only a step to modifying a higher animal, even man.
Reported in 1981, expressing concern for the future of gene-splicing.

It appears, nevertheless, that all such simple solutions of the problem of vertebrate ancestry are without warrant. They arise from a very common tendency of the mind, against which the naturalist has to guard himself,—a tendency which finds expression in the very widespread notion that the existing anthropoid apes, and more especially the gorilla, must be looked upon as the ancestors of mankind, if once the doctrine of the descent of man from ape-like forefathers is admitted. A little reflexion suffices to show that any given living form, such as the gorilla, cannot possibly be the ancestral form from which man was derived, since ex-hypothesi that ancestral form underwent modification and development, and in so doing, ceased to exist.

Second Law
All the acquisitions or losses wrought by nature on individuals, through the influence of the environment in which their race has long been placed, and hence through the influence of the predominant use or permanent disuse of any organ; all these are preserved by reproduction to the new individuals which arise, provided that the acquired modifications are common to both sexes, or at least to the individuals which produce the young.

We may lay it down as an incontestible axiom, that, in all the operations of art and nature, nothing is created; an equal quantity of matter exists both before and after the experiment; the quality and quantity of the elements remain precisely the same; and nothing takes place beyond changes and modifications in the combination of these elements. Upon this principle the whole art of performing chemical experiments depends: We must always suppose an exact equality between the elements of the body examined and those of the products of its analysis.