A game is on, at the other end of this infinite distance, and heads or tails will turn up. What will you wager? According to reason you cannot leave either; according to reason you cannot leave either undone... Yes, but wager you must; there is no option, you have embarked on it. So which will you have. Come. Since you must choose, let us see what concerns you least. You have two things to lose: truth and good, and two things to stake: your reason and your will, your knowledge and your happiness. And your nature has two things to shun: error and misery. Your reason does not suffer by your choosing one more than the other, for you must choose. That is one point cleared. But your happiness? Let us weigh gain and loss in calling heads that God is. Reckon these two chances: if you win, you win all; if you lose, you lose naught. Then do not hesitate, wager that He is.

A grove of giant redwoods or sequoias should be kept just as we keep a great or beautiful cathedral. The extermination of the passenger pigeon meant that mankind was just so much poorer; exactly as in the case of the destruction of the cathedral at Rheims. And to lose the chance to see frigate-birds soaring in circles above the storm, or a file of pelicans winging their way homeward across the crimson afterglow of the sunset, or a myriad terns flashing in the bright light of midday as they hover in a shifting maze above the beach—why, the loss is like the loss of a gallery of the masterpieces of the artists of old time.

Astronomers and physicists, dealing habitually with objects and quantities far beyond the reach of the senses, even with the aid of the most powerful aids that ingenuity has been able to devise, tend almost inevitably to fall into the ways of thinking of men dealing with objects and quantities that do not exist at all, e.g., theologians and metaphysicians. Thus their speculations tend almost inevitably to depart from the field of true science, which is that of precise observation, and to become mere soaring in the empyrean. The process works backward, too. That is to say, their reports of what they pretend actually to see are often very unreliable. It is thus no wonder that, of all men of science, they are the most given to flirting with theology. Nor is it remarkable that, in the popular belief, most astronomers end by losing their minds.

Astronomy is, not without reason, regarded, by mankind, as the sublimest of the natural sciences. Its objects so frequently visible, and therefore familiar, being always remote and inaccessible, do not lose their dignity.

Books won't stay banned. They won't burn. Ideas won't go to jail. In the long run of history, the censor and the inquisitor have always lost. The only sure weapon against bad ideas is better ideas. The source of better ideas is wisdom. The surest path to wisdom is a liberal education.

But I don't have to know an answer. I don't feel frightened by not knowing things, by being lost in a mysterious universe within any purpose, which is the way it really is, so far as I can tell. It doesn't frighten me.

By the death of Mr. O. Chanute the world has lost one whose labors had to an unusual degree influenced the course of human progress. If he had not lived the entire history of progress in flying would have been other than it has been.

Charles Babbage proposed to make an automaton chess-player which should register mechanically the number of games lost and gained in consequence of every sort of move. Thus, the longer the automaton went on playing game, the more experienced it would become by the accumulation of experimental results. Such a machine precisely represents the acquirement of experience by our nervous organization.

Chemists do have a good sense of humor but lose it when they serve as referees.

Every phenomenon, however trifling it be, has a cause, and a mind infinitely powerful, and infinitely well-informed concerning the laws of nature could have foreseen it from the beginning of the ages. If a being with such a mind existed, we could play no game of chance with him; we should always lose.

Far be it from me to suggest that geologists should be reckless in their drafts upon the bank of Time; but nothing whatever is gained, and very much is lost, by persistent niggardliness in this direction.

Force, then, is Force, but mark you! Not a thing,
Only a Vector;
Thy barbèd arrows now have lost their sting,
Impotent spectre!
Thy reign, O force! is over. Now no more
Heed we thine action;
Repulsion leaves us where we were before,
So does attraction.
Both Action and Reaction now are gone.
Just ere they vanished,
Stress joined their hands in peace, and made them one;
Then they were banished....

I believe that natural history has lost much by the vague general treatment that is so common.

I feel more confident and more satisfied when I reflect that I have two professions and not one. Medicine is my lawful wife and literature is my mistress. When I get tired of one I spend the night with the other. Though it's disorderly it's not so dull, and besides, neither really loses anything, through my infidelity.

If it is good to teach students about the chemical industry then why is it not good to assign ethical qualities to substances along with their physical and chemical ones? We might for instance say that CS [gas] is a bad chemical because it can only ever be used by a few people with something to protect against many people with nothing to lose. Terylene or indigotin are neutral chemicals. Under capitalism their production is an exploitive process, under socialism they are used for the common good. Penicillin is a good chemical.

If you have built castles in the air, your work need not be lost; that is where they should be. Now put the foundations under them.

In the dog two conditions were found to produce pathological disturbances by functional interference, namely, an unusually acute clashing of the excitatory and inhibitory processes, and the influence of strong and extraordinary stimuli. In man precisely similar conditions constitute the usual causes of nervous and psychic disturbances. Different conditions productive of extreme excitation, such as intense grief or bitter insults, often lead, when the natural reactions are inhibited by the necessary restraint, to profound and prolonged loss of balance in nervous and psychic activity.

In the vestibule of the Manchester Town Hall are placed two life-sized marble statues facing each other. One of these is that of John Dalton ... the other that of James Prescott Joule. ... Thus the honour is done to Manchester's two greatest sons—to Dalton, the founder of modern Chemistry and of the atomic theory, and the laws of chemical-combining proportions; to Joule, the founder of modern physics and the discoverer of the Law of Conservation of Energy.
One gave to the world the final proof ... that in every kind of chemical change no loss of matter occurs; the other proved that in all the varied modes of physical change, no loss of energy takes place.

In vertebrate paleontology, increasing knowledge leads to triumphant loss of clarity.

It is impossible to imagine the universe run by a wise, just and omnipotent God, but it is quite easy to imagine it run by a board of gods. If such a board actually exists it operates precisely like the board of a corporation that is losing money.

It was not easy for a person brought up in the ways of classical thermodynamics to come around to the idea that gain of entropy eventually is nothing more nor less than loss of information.

Just remember - when you think all is lost, the future remains.

Life through many long periods has been manifested in a countless host of varying structures, all circumscribed by one general plan, each appointed to a definite place, and limited to an appointed duration. On the whole the earth has been thus more and more covered by the associated life of plants and animals, filling all habitable space with beings capable of enjoying their own existence or ministering to the enjoyment of others; till finally, after long preparation, a being was created capable of the wonderful power of measuring and weighing all the world of matter and space which surrounds him, of treasuring up the past history of all the forms of life, and considering his own relation to the whole. When he surveys this vast and co-ordinated system, and inquires into its history and origin, can he be at a loss to decide whether it be a work of Divine thought and wisdom, or the fortunate offspring of a few atoms of matter, warmed by the anima mundi, a spark of electricity, or an accidental ray of sunshine?

Many Species of Animals have been lost out of the World, which Philosophers and Divines are unwilling to admit, esteeming the Destruction of anyone Species a Dismembring of the Universe, and rendring the World imperfect; whereas they think the Divine Providence is especially concerned, and solicitous to secure and preserve the Works of the Creation. And truly so it is, as appears, in that it was so careful to lodge all Land Animals in the Ark at the Time of the general Deluge; and in that, of all Animals recorded in Natural Histories, we cannot say that there hath been anyone Species lost, no not of the most infirm, and most exposed to Injury and Ravine. Moreover, it is likely, that as there neither is nor can be any new Species of Animals produced, all proceeding from Seeds at first created; so Providence, without which one individual Sparrow falls not to the ground, doth in that manner watch over all that are created, that an entire Species shall not be lost or destroyed by any Accident. Now, I say, if these Bodies were sometimes the Shells and Bones of Fish, it will thence follow, that many Species have been lost out of the World... To which I have nothing to reply, but that there may be some of them remaining some where or other in the Seas, though as yet they have not come to my Knowledge. Far though they may have perished, or by some Accident been destroyed out of our Seas, yet the Race of them may be preserved and continued still in others.

Nothing is lost and nothing is created in the operations of art as those of nature.

Seldom, if ever, was any knowledge given to keep but to impart; the grace of this rich jewel is lost in concealment.

Suppose it were perfectly certain that the life and fortune of every one of us would, one day or other, depend upon his winning or losing a game of chess. Don't you think that we should all consider it to be a primary duty to learn at least the names and the moves of the pieces; to have a notion of a gambit, and a keen eye for all the means of giving and getting out of check? Do you not think that we should look with a disapprobation amounting to scorn upon the father who allowed his son, or the state which allowed its members, to grow up without knowing a pawn from a knight?
Yet, it is a very plain and elementary truth that the life, the fortune, and the happiness of every one of us, and, more or less, of those who are connected with us, do depend upon our knowing something of the rules of a game infinitely more difficult and complicated than chess. It is a game which has been played for untold ages, every man and woman of us being one of the two players in a game of his or her own. The chess-board is the world, the pieces are the phenomena of the universe, the rules of the game are what we call the laws of nature. The player on the other side is hidden from us. We know that his play is always fair, just, and patient. But also we know, to our cost, that he never overlooks a mistake, or makes the smallest allowance for ignorance. To the man who plays well the highest stakes are paid with that sort of overflowing generosity with which the strong shows delight in strength. And one who plays ill is checkmated—without haste, but without remorse.

The best class of scientific mind is the same as the best class of business mind. The great desideratum in either case is to know how much evidence is enough to warrant action. It is as unbusiness-like to want too much evidence before buying or selling as to be content with too little. The same kind of qualities are wanted in either case. The difference is that if the business man makes a mistake, he commonly has to suffer for it, whereas it is rarely that scientific blundering, so long as it is confined to theory, entails loss on the blunderer. On the contrary it very often brings him fame, money and a pension. Hence the business man, if he is a good one, will take greater care not to overdo or underdo things than the scientific man can reasonably be expected to take.

The extraordinary development of modern science may be her undoing. Specialism, now a necessity, has fragmented the specialities themselves in a way that makes the outlook hazardous. The workers lose all sense of proportion in a maze of minutiae.

The fairest thing we can experience is the mysterious. It is the fundamental emotion which stands at the cradle of true science. He who knows it not, and can no longer wonder, no longer feel amazement, is as good as dead. We all had this priceless talent when we were young. But as time goes by, many of us lose it. The true scientist never loses the faculty of amazement. It is the essence of his being.

The most disgraceful cause of the scarcity [of remedies] is that even those who know them do not want to point them out, as if they were going to lose what they pass on to others.

The vacuum-apparatus requires that its manipulators constantly handle considerable amounts of mercury. Mercury is a strong poison, particularly dangerous because of its liquid form and noticeable volatility even at room temperature. Its poisonous character has been rather lost sight of during the present generation. My co-workers and myself found from personal experience-confirmed on many sides when published—that protracted stay in an atmosphere charged with only 1/100 of the amount of mercury required for its saturation, sufficed to induce chronic mercury poisoning. This first reveals itself as an affection of the nerves, causing headaches, numbness, mental lassitude, depression, and loss of memory; such are very disturbing to one engaged in intellectual occupations.

We are all dietetic sinners; only a small percent of what we eat nourishes us, the balance goes to waste and loss of energy .

We have not the reverent feeling for the rainbow that a savage has, because we know how it is made. We have lost as much as we gained by prying into that matter.

When I received the Nobel Prize, the only big lump sum of money I have ever seen, I had to do something with it. The easiest way to drop this hot potato was to invest it, to buy shares. I knew that World War II was coming and I was afraid that if I had shares which rise in case of war, I would wish for war. So I asked my agent to buy shares which go down in the event of war. This he did. I lost my money and saved my soul.

X-rays ... I am afraid of them. I stopped experimenting with them two years ago, when I came near to losing my eyesight and Dally, my assistant practically lost the use of both of his arms.

[Have we lost faith?] Certainly not, but we have only transferred it from God to the General Medical Council.