A discovery must be, by definition, at variance with existing knowledge. During my lifetime, I made two. Both were rejected offhand by the popes of the field. Had I predicted these discoveries in my applications, and had those authorities been my judges, it is evident what their decisions would have been.

How strange it would be if the final theory were to be discovered in our lifetimes! The discovery of the final laws of nature will mark a discontinuity in human intellectual history, the sharpest that has occurred since the beginning of modern science in the seventeenth century. Can we now imagine what that would be like?

If the Weismann idea triumphs, it will be in a sense a triumph of fatalism; for, according to it, while we may indefinitely improve the forces of our education and surroundings, and this civilizing nurture will improve the individuals of each generation, its actual effects will not be cumulative as regards the race itself, but only as regards the environment of the race; each new generation must start de novo, receiving no increment of the moral and intellectual advance made during the lifetime of its predecessors. It would follow that one deep, almost instinctive motive for a higher life would be removed if the race were only superficially benefited by its nurture, and the only possible channel of actual improvement were in the selection of the fittest chains of race plasma.

One day at Fenner's (the university cricket ground at Cambridge), just before the last war, G. H. Hardy and I were talking about Einstein. Hardy had met him several times, and I had recently returned from visiting him. Hardy was saying that in his lifetime there had only been two men in the world, in all the fields of human achievement, science, literature, politics, anything you like, who qualified for the Bradman class. For those not familiar with cricket, or with Hardy's personal idiom, I ought to mention that 'the Bradman class' denoted the highest kind of excellence: it would include Shakespeare, Tolstoi, Newton, Archimedes, and maybe a dozen others. Well, said Hardy, there had only been two additions in his lifetime. One was Lenin and the other Einstein.

Owing to his lack of knowledge, the ordinary man cannot attempt to resolve conflicting theories of conflicting advice into a single organized structure. He is likely to assume the information available to him is on the order of what we might think of as a few pieces of an enormous jigsaw puzzle. If a given piece fails to fit, it is not because it is fraudulent; more likely the contradictions and inconsistencies within his information are due to his lack of understanding and to the fact that he possesses only a few pieces of the puzzle. Differing statements about the nature of things, differing medical philosophies, different diagnoses and treatments—all of these are to be collected eagerly and be made a part of the individual's collection of puzzle pieces. Ultimately, after many lifetimes, the pieces will fit together and the individual will attain clear and certain knowledge.

The fundamental characteristic of the scientific method is honesty. In dealing with any question, science asks no favors. ... I believe that constant use of the scientific method must in the end leave its impress upon him who uses it. ... A life spent in accordance with scientific teachings would be of a high order. It would practically conform to the teachings of the highest types of religion. The motives would be different, but so far as conduct is concerned the results would be practically identical.

The very closest stars would require many years to visit, even traveling at the speed of light, which is impossible according to Einstein's theory of relativity. Today's fastest spaceships would require 200,000 years to travel to Alpha Centauri, our closest bright star. The energy required to send a hundred colonists to another star, as Frank Drake has pointed out, would be enough to meet the energy needs of the entire United States over a human lifetime. And these estimates are regarding nearby stars. When we consider the distances across the entire galaxy, and between galaxies, interstellar travel seems absolutely untenable.
[Co-author with his son, Marshall Fisher]

We have simply arrived too late in the history of the universe to see this primordial simplicity easily ... But although the symmetries are hidden from us, we can sense that they are latent in nature, governing everything about us. That's the most exciting idea I know: that nature is much simpler than it looks. Nothing makes me more hopeful that our generation of human beings may actually hold the key to the universe in our hands—that perhaps in our lifetimes we may be able to tell why all of what we see in this immense universe of galaxies and particles is logically inevitable.