Clarke's First Law: When a distinguished but elderly scientist states that something is possible, he is almost certainly right. When he states that something is impossible, he is very probably wrong.

A first-rate laboratory is one in which mediocre scientists can produce outstanding work.

A neat and orderly laboratory is unlikely. It is, after all, so much a place of false starts and multiple attempts.

A physician's subject of study is necessarily the patient, and his first field for observation is the hospital. But if clinical observation teaches him to know the form and course of diseases, it cannot suffice to make him understand their nature; to this end he must penetrate into the body to find which of the internal parts are injured in their functions. That is why dissection of cadavers and microscopic study of diseases were soon added to clinical observation. But to-day these various methods no longer suffice; we must push investigation further and, in analyzing the elementary phenomena of organic bodies, must compare normal with abnormal states. We showed elsewhere how incapable is anatomy alone to take account of vital phenenoma, and we saw that we must add study of all physico-chemical conditions which contribute necessary elements to normal or pathological manifestations of life. This simple suggestion already makes us feel that the laboratory of a physiologist-physician must be the most complicated of all laboratories, because he has to experiment with phenomena of life which are the most complex of all natural phenomena.

A study of Disease—of Pestilences methodically prepared and deliberately launched upon man and beast—is certainly being pursue in the laboratories of more than one great country. Blight to destroy crops, Anthrax to slay horses and cattle, Plague to poison not armies but whole districts—such are the lines along which military science is remorselessly advancing.

A tidy laboratory means a lazy chemist.

According to my views, aiming at quantitative investigations, that is at establishing relations between measurements of phenomena, should take first place in the experimental practice of physics. By measurement to knowledge [door meten tot weten] I should like to write as a motto above the entrance to every physics laboratory.

All the world is a laboratory to the inquiring mind.

As he approached the place where a meeting of doctors was being held, he saw some elegant limousines and remarked, “The surgeons have arrived.” Then he saw some cheaper cars and said, “The physicians are here, too.” ... And when he saw a row of overshoes inside, under the hat rack, he is reported to have remarked, “Ah, I see there are laboratory men here.”

At my urgent request the Curie laboratory, in which radium was discovered a short time ago, was shown to me. The Curies themselves were away travelling. It was a cross between a stable and a potato-cellar, and, if I had not seen the worktable with the chemical apparatus, I would have thought it a practical joke.
Wilhelm Ostwald on seeing the Curie's laboratory facilities.

AZT stood up and said, 'Stop your pessimism. Stop your sense of futility. Go back to the lab. Go back to development. Go back to clinical trials. Things will work.'
[On the impact of AZT emerging as the long-sought first significant AIDS drug.]

But, contrary to the lady's prejudices about the engineering profession, the fact is that quite some time ago the tables were turned between theory and applications in the physical sciences. Since World War II the discoveries that have changed the world are not made so much in lofty halls of theoretical physics as in the less-noticed labs of engineering and experimental physics. The roles of pure and applied science have been reversed; they are no longer what they were in the golden age of physics, in the age of Einstein, Schrödinger, Fermi and Dirac.

D'you know how embarrassing it is to mention good and evil in a scientific laboratory? Have you any idea? One of the reasons l became a scientist was not to have to think about that kind of thing.

Direct observation of the testimony of the earth ... is a matter of the laboratory, of the field naturalist, of indefatigable digging among the ancient archives of the earth's history. If Mr. Bryan, with an open heart and mind, would drop all his books and all the disputations among the doctors and study first hand the simple archives of Nature, all his doubts would disappear; he would not lose his religion; he would become an evolutionist.

Don't despise empiric truth. Lots of things work in practice for which the laboratory has never found proof.

Experiments in geology are far more difficult than in physics and chemistry because of the greater size of the objects, commonly outside our laboratories, up to the earth itself, and also because of the fact that the geologic time scale exceeds the human time scale by a million and more times. This difference in time allows only direct observations of the actual geologic processes, the mind having to imagine what could possibly have happened in the past.

From him [Wilard Bennett] I learned how different a working laboratory is from a student laboratory. The answers are not known!
[While an undergraduate, doing experimental measurements in the laboratory of his professor, at Ohio State University.]

Graduates engaged in post-graduate work are reminded that their Supervisor is a University Officer and when visiting him officially in that capacity they should dress as they would in visiting any other officers of the University or of their own College (e.g. a tutor). Gowns, however, need not be worn in the chemical laboratory.

I always tried to live up to Leo Szilard's commandment, 'don't lie if you don't have to.' I had to. I filled up pages with words and plans I knew I would not follow. When I go home from my laboratory in the late afternoon, I often do not know what I am going to do the next day. I expect to think that up during the night. How could I tell them what I would do a year hence?

I feel that, in a sense, the writer knows nothing any longer. He has no moral stance. He offers the reader the contents of his own head, a set of options and imaginative alternatives. His role is that of a scientist, whether on safari or in his laboratory, faced with an unknown terrain or subject. All he can do is to devise various hypotheses and test them against the facts.

I have no dress except the one I wear every day. If you are going to be kind enough to give me one, please let it be practical and dark so that I can put it on afterwards to go to the laboratory.
[Referring to her wedding dress.]

I have seen many phases of life; I have moved in imperial circles, I have been a Minister of State; but if I had to live my life again, I would always remain in my laboratory, for the greatest joy of my life has been to accomplish original scientific work, and, next to that, to lecture to a set of intelligent students.

I noticed affixed to a laboratory door the following words: “Les théories passent. Le Grenouille reste. [The theories pass. The frog remains.] &mdashJean Rostand, Carnets d’un biologiste.” There is a risk that in the less severe discipline of criticism the result may turn out to be different; the theories will remain but the frog may disappear.

I ought to say that one of our first joint researches, so far as publication was concerned, had the peculiar effect of freeing me forever from the wiles of college football, and if that is a defect, make the most of it! Dr. Noyes and I conceived an idea on sodium aluminate solutions on the morning of the day of a Princeton-Harvard game (as I recall it) that we had planned to attend. It looked as though a few days' work on freezing-point determinations and electrical conductivities would answer the question. We could not wait, so we gave up the game and stayed in the laboratory. Our experiments were successful. I think that this was the last game I have ever cared about seeing. I mention this as a warning, because this immunity might attack anyone. I find that I still complainingly wonder at the present position of football in American education.

I prefer the spagyric chemical physicians, for they do not consort with loafers or go about gorgeous in satins, silks and velvets, gold rings on their fingers, silver daggers hanging at their sides and white gloves on their hands, but they tend their work at the fire patiently day and night. They do not go promenading, but seek their recreation in the laboratory, wear plain learthern dress and aprons of hide upon which to wipe their hands, thrust their fingers amongst the coals, into dirt and rubbish and not into golden rings. They are sooty and dirty like the smiths and charcoal burners, and hence make little show, make not many words and gossip with their patients, do not highly praise their own remedies, for they well know that the work must praise the master, not the master praise his work. They well know that words and chatter do not help the sick nor cure them... Therefore they let such things alone and busy themselves with working with their fires and learning the steps of alchemy. These are distillation, solution, putrefaction, extraction, calcination, reverberation, sublimination, fixation, separation, reduction, coagulation, tinction, etc.

I want to get out in the water. I want to see fish, real fish, not fish in a laboratory.

I was fascinated by fractional distillation as a method while still a school-boy, and built in the cellar of my home, which was my combined workshop and laboratory, distillation columns, packed with coke of graded size, some five feet in height. They were made from coffee tins (obtained from the kitchen), with the bottoms removed and soldered together! Experience with them served me in good stead and by the time I graduated I had a good understanding of the problems of fractional distillation.

I went to the trash pile at Tuskegee Institute and started my laboratory with bottles, old fruit jars and any other thing I found I could use. ... [The early efforts were] worked out almost wholly on top of my flat topped writing desk and with teacups, glasses, bottles and reagents I made myself.

I would like to emphasize strongly my belief that the era of computing chemists, when hundreds if not thousands of chemists will go to the computing machine instead of the laboratory for increasingly many facets of chemical information, is already at hand. There is only one obstacle, namely that someone must pay for the computing time.

If a little less time was devoted to the translation of letters by Julius Caesar describing Britain 2000 years ago and a little more time was spent on teaching children how to describe (in simple modern English) the method whereby ethylene was converted into polythene in 1933 in the ICI laboratories at Northwich, and to discussing the enormous social changes which have resulted from this discovery, then I believe that we should be training future leaders in this country to face the world of tomorrow far more effectively than we are at the present time.

In a University we are especially bound to recognise not only the unity of science itself, but the communion of the workers in science. We are too apt to suppose that we are congregated here merely to be within reach of certain appliances of study, such as museums and laboratories, libraries and lecturers, so that each of us may study what he prefers. I suppose that when the bees crowd round the flowers it is for the sake of the honey that they do so, never thinking that it is the dust which they are carrying from flower to flower which is to render possible a more splendid array of flowers, and a busier crowd of bees, in the years to come. We cannot, therefore, do better than improve the shining hour in helping forward the cross-fertilization of the sciences.

In a word, I consider hospitals only as the entrance to scientific medicine; they are the first field of observation which a physician enters; but the true sanctuary of medical science is a laboratory; only there can he seek explanations of life in the normal and pathological states by means of experimental analysis.

In physics, mathematics, and astronautics [elderly] means over thirty; in the other disciplines, senile decay is sometimes postponed to the forties. There are, of course, glorious exceptions; but as every researcher just out of college knows, scientists of over fifty are good for nothing but board meetings, and should at all costs be kept out of the laboratory!
Defining 'elderly scientist' as in Clarke's First Law.

In the laboratory there are no fustian ranks, no brummagem aristocracies; the domain of Science is a republic, and all its citizens are brothers and equals, its princes of Monaco and its stonemasons of Cromarty meeting, barren of man-made gauds and meretricious decorations, upon the one majestic level!

It must be admitted that science has its castes. The man whose chief apparatus is the differential equation looks down upon one who uses a galvanometer, and he in turn upon those who putter about with sticky and smelly things in test tubes. But all of these, and most biologists too, join together in their contempt for the pariah who, not through a glass darkly, but with keen unaided vision, observes the massing of a thundercloud on the horizon, the petal as it unfolds, or the swarming of a hive of bees. And yet sometimes I think that our laboratories are but little earthworks which men build about themselves, and whose puny tops too often conceal from view the Olympian heights; that we who work in these laboratories are but skilled artisans compared with the man who is able to observe, and to draw accurate deductions from the world about him.

It's becoming clear that in a sense the cosmos provides the only laboratory where sufficiently extreme conditions are ever achieved to test new ideas on particle physics. The energies in the Big Bang were far higher than we can ever achieve on Earth. So by looking at evidence for the Big Bang, and by studying things like neutron stars, we are in effect learning something about fundamental physics.

It's hard to imagine anything more difficult to study than human sexuality, on every level from the technical to the political. One has only to picture monitoring orgasm in the lab to begin to grasp the challenge of developing testing techniques that are thorough and precise, yet respectful.

Liebig taught the world two great lessons. The first was that in order to teach chemistry it was necessary that students should be taken into a laboratory. The second lesson was that he who is to apply scientific thought and method to industrial problems must have a thorough knowledge of the sciences. The world learned the first lesson more readily than it learned the second.

Like thousands of other boys, I had a little chemical laboratory in our cellar and think that some of our friends thought me a bit crazy.

Live in the serene peace of laboratories and libraries

Many of the things that have happened in the laboratory have happened in ways it would have been impossible to foresee, but not impossible to plan for in a sense. I do not think Dr. Whitney deliberately plans his serendipity but he is built that way; he has the art—an instinctive way of preparing himself by his curiosity and by his interest in people and in all kinds of things and in nature, so that the things he learns react on one another and thereby accomplish things that would be impossible to foresee and plan.

Microbiology Lab - Staph Only

Remsen never wore his hat inside the door for he had much the same respect for his laboratory that most of us have for a church.

Sometimes my courage fails me and I think I ought to stop working, live in the country and devote myself to gardening. But I am held by a thousand bonds, and I don't know when I shall be able to arrange things otherwise. Nor do I know whether, even by writing scientific books, I could live without the laboratory.

Speaking one day to Monsieur de Buffon, on the present ardor of chemical inquiry, he affected to consider chemistry but as cookery, and to place the toils of the laboratory on the footing with those of the kitchen. I think it, on the contrary, among the most useful of sciences, and big with future discoveries for the utility and safety of the human race.

Students using astrophysical textbooks remain essentially ignorant of even the existence of plasma concepts, despite the fact that some of them have been known for half a century. The conclusion is that astrophysics is too important to be left in the hands of astrophysicists who have gotten their main knowledge from these textbooks. Earthbound and space telescope data must be treated by scientists who are familiar with laboratory and magnetospheric physics and circuit theory, and of course with modern plasma theory.
[Lamenting the traditional neglect of plasma physics]

The faith of scientists in the power and truth of mathematics is so implicit that their work has gradually become less and less observation, and more and more calculation. The promiscuous collection and tabulation of data have given way to a process of assigning possible meanings, merely supposed real entities, to mathematical terms, working out the logical results, and then staging certain crucial experiments to check the hypothesis against the actual empirical results. But the facts which are accepted by virtue of these tests are not actually observed at all. With the advance of mathematical technique in physics, the tangible results of experiment have become less and less spectacular; on the other hand, their significance has grown in inverse proportion. The men in the laboratory have departed so far from the old forms of experimentation—typified by Galileo's weights and Franklin's kite—that they cannot be said to observe the actual objects of their curiosity at all; instead, they are watching index needles, revolving drums, and sensitive plates. No psychology of 'association' of sense-experiences can relate these data to the objects they signify, for in most cases the objects have never been experienced. Observation has become almost entirely indirect; and readings take the place of genuine witness.

The laboratory was an unattractive half basement and low ceilinged room with an inner dark room for the galvanometer and experimental animals. It was dark, crowded with equipment and uninviting. Into it came patients for electrocardiography, dogs for experiments, trays with coffee and buns for lunch. It was hot and dusty in summer and cold in winter. True a large fire burnt brightly in the winter but anyone who found time to warm his backside at it was not beloved by [Sir Thomas] Lewis. It was no good to try and look out of the window for relaxation, for it was glazed with opaque glass. The scientific peaks were our only scenery, and it was our job to try and find the pathways to the top.

The landed classes neglected technical education, taking refuge in classical studies; as late as 1930, for example, long after Ernest Rutherford at Cambridge had discovered the atomic nucleus and begun transmuting elements, the physics laboratory at Oxford had not been wired for electricity. Intellectual neglect technical education to this day.
[Describing C.P. Snow's observations on the neglect of technical education.]

The lives of scientists, considered as Lives, almost always make dull reading. For one thing, the careers of the famous and the merely ordinary fall into much the same pattern, give or take an honorary degree or two, or (in European countries) an honorific order. It could be hardly otherwise. Academics can only seldom lead lives that are spacious or exciting in a worldly sense. They need laboratories or libraries and the company of other academics. Their work is in no way made deeper or more cogent by privation, distress or worldly buffetings. Their private lives may be unhappy, strangely mixed up or comic, but not in ways that tell us anything special about the nature or direction of their work. Academics lie outside the devastation area of the literary convention according to which the lives of artists and men of letters are intrinsically interesting, a source of cultural insight in themselves. If a scientist were to cut his ear off, no one would take it as evidence of a heightened sensibility; if a historian were to fail (as Ruskin did) to consummate his marriage, we should not suppose that our understanding of historical scholarship had somehow been enriched.

The mathematics of cooperation of men and tools is interesting. Separated men trying their individual experiments contribute in proportion to their numbers and their work may be called mathematically additive. The effect of a single piece of apparatus given to one man is also additive only, but when a group of men are cooperating, as distinct from merely operating, their work raises with some higher power of the number than the first power. It approaches the square for two men and the cube for three. Two men cooperating with two different pieces of apparatus, say a special furnace and a pyrometer or a hydraulic press and new chemical substances, are more powerful than their arithmetical sum. These facts doubtless assist as assets of a research laboratory.

The Mecca of the biological world.
Describing the Naples Biological Station, one of the world’s leading marine laboratories in the world.

The mind is a vagrant thing ... Thinking is not analogous to a person working in a laboratory who invents something on company time.
Answering criticism that the book for which he won a Pulitzer Prize was written in the years he had been employed at the Smithsonian. He specified that did not write on the premises there, but only at home outside of working hours.

The modern research laboratory can be a large and complicated social organism.

The stories of Whitney's love for experimenting are legion. At one time he received a letter asking if insects could live in a vacuum. Whitney took the letter to one of the members of his staff and asked the man if he cared to run an experiment on the subject. The man replied that there was no point in it, since it was well established that life could not exist without a supply of oxygen. Whitney, who was an inveterate student of wild life, replied that on his farm he had seen turtles bury themselves in mud each fall, and, although the mud was covered with ice and snow for months, emerge again in the spring. The man exclaimed, "Oh, you mean hibernation!" Whitney answered, "I don't know what I mean, but I want to know if bugs can live in a vacuum."
He proceeded down the hall and broached the subject to another member of the staff. Faced with the same lack of enthusiasm for pursuing the matter further, Whitney tried another illustration. "I've been told that you can freeze a goldfish solidly in a cake of ice, where he certainly can't get much oxygen, and can keep him there for a month or two. But if you thaw him out carefully he seems none the worse for his experience." The second scientist replied, "Oh, you mean suspended animation." Whitney once again explained that his interest was not in the terms but in finding an answer to the question.
Finally Whitney returned to his own laboratory and set to work. He placed a fly and a cockroach in a bell jar and removed the air. The two insects promptly keeled over. After approximately two hours, however, when he gradually admitted air again, the cockroach waved its feelers and staggered to its feet. Before long, both the cockroach and the fly were back in action.

There is no short cut from chemical laboratory to clinic, except one that passes too close to the morgue.

There is only one thing worse than coming home from the lab to a sink full of dirty dishes, and that is not going to the lab at all!

Time... is an essential requirement for effective research. An investigator may be given a palace to live in, a perfect laboratory to work in, he may be surrounded by all the conveniences money can provide; but if his time is taken from him he will remain sterile.

Tungsten, X-rays, and Coolidge form a trinity that has left an indelible impression upon our life and times. The key word in this triad is Coolidge, for his work brought the element tungsten from laboratory obscurity to the central role of the industrial stage and gave the X-ray a central role in the progress of medicine throughout the world.

We have seen that a proton of energy corresponding to 30,000 volts can effect the transformation of lithium into two fast α-particles, which together have an energy equivalent of more than 16 million volts. Considering the individual process, the output of energy in the transmutation is more than 500 times greater than the energy carried by the proton. There is thus a great gain of energy in the single transmutation, but we must not forget that on an average more than 1000 million protons of equal energy must be fired into the lithium before one happens to hit and enter the lithium nucleus. It is clear in this case that on the whole the energy derived from transmutation of the atom is small compared with the energy of the bombarding particles. There thus seems to be little prospect that we can hope to obtain a new source of power by these processes. It has sometimes been' suggested, from analogy with ordinary explosives, that the transmutation of one atom might cause the transmutation of a neighbouring nucleus, so that the explosion would spread throughout all the material. If this were true, we should long ago have had a gigantic explosion in our laboratories with no one remaining to tell the tale. The absence of these accidents indicates, as we should expect, that the explosion is confined to the individual nucleus and does not spread to the neighbouring nuclei, which may be regarded as relatively far removed from the centre of the explosion.

When chemists have brought their knowledge out of their special laboratories into the laboratory of the world, where chemical combinations are and have been through all time going on in such vast proportions,—when physicists study the laws of moisture, of clouds and storms, in past periods as well as in the present,—when, in short, geologists and zoologists are chemists and physicists, and vice versa,—then we shall learn more of the changes the world has undergone than is possible now that they are separately studied.

When it was first proposed to establish laboratories at Cambridge, Todhunter, the mathematician, objected that it was unnecessary for students to see experiments performed, since the results could be vouched for by their teachers, all of them of the highest character, and many of them clergymen of the Church of England.

You are urgently warned against allowing yourself to be influenced in any way by theories or by other preconceived notions in the observation of phenomena, the performance of analyses and other determinations.

You know, I am sorry for the poor fellows that haven't got labs to work in.

[Chemistry] laboratory work was my first challenge. ... I still carry the scars of my first discovery—that test-tubes are fragile.

[The surplus of basic knowledge of the atomic nucleus was] largely used up [during the war with the atomic bomb as the dividend.] We must, without further delay restore this surplus in preparation for the important peacetime job for the nucleus - power production. ... Many of the proposed applications of atomic power - even for interplanetary rockets - seem to be within the realm of possibility provided the economic factor is ruled out completely, and the doubtful physical and chemical factors are weighted heavily on the optimistic side. ... The development of economic atomic power is not a simple extrapolation of knowledge gained during the bomb work. It is a new and difficult project to reach a satisfactory answer. Needless to say, it is vital that the atomic policy legislation now being considered by the congress recognizes the essential nature of this peacetime job, and that it not only permits but encourages the cooperative research-engineering effort of industrial, government and university laboratories for the task. ... We must learn how to generate the still higher energy particles of the cosmic rays - up to 1,000,000,000 volts, for they will unlock new domains in the nucleus.