...I believe there exists, & I feel within me, an instinct for the truth, or knowledge or discovery, of something of the same nature as the instinct of virtue, & that our having such an instinct is reason enough for scientific researches without any practical results ever ensuing from them.

Ipsa Scientia potestas est.
For also knowledge itself is power.

A ... difference between most system-building in the social sciences and systems of thought and classification of the natural sciences is to be seen in their evolution. In the natural sciences both theories and descriptive systems grow by adaptation to the increasing knowledge and experience of the scientists. In the social sciences, systems often issue fully formed from the mind of one man. Then they may be much discussed if they attract attention, but progressive adaptive modification as a result of the concerted efforts of great numbers of men is rare.

A scientist strives to understand the work of Nature. But with our insufficient talents as scientists, we do not hit upon the truth all at once. We must content ourselves with tracking it down, enveloped in considerable darkness, which leads us to make new mistakes and errors. By diligent examination, we may at length little by little peel off the thickest layers, but we seldom get the core quite free, so that finally we have to be satisfied with a little incomplete knowledge.

Activity is the only road to knowledge.

All knowledge attains its ethical value and its human significance only by the human sense with which it is employed. Only a good man can be a great physician.

All knowledge has an ultimate goal. Knowledge for the sake of knowledge is, say what you will, nothing but a dismal begging of the question.

All men by nature desire to know.

All science is full of statements where you put your best face on your ignorance, where you say: ... we know awfully little about this, but more or less irrespective of the stuff we don't know about, we can make certain useful deductions.

All things are made of atoms—little particles that move around in perpetual motion, attracting each other when they are a little distance apart, but repelling upon being squeezed into one another. In that one sentence ... there is an enormous amount of information about the world.
His suggestion that the most valuable information on scientific knowledge in a single sentence using the fewest words is to state the atomic hypothesis.

And men ought to know that from nothing else but thence [from the brain] come joys, delights, laughter and sports, and sorrows, griefs, despondency, and lamentations. And by this, in an especial manner, we acquire wisdom and knowledge, and see and hear, and know what are foul and hat are fair, what are bad and what are good, what are sweet, and what unsavory... And by the same organ we become mad and delirious, and fears and terrors assail us... All these things we endure from the brain, when it is not healthy... In these ways I am of the opinion that the brain exercises the greatest power in the man. This is the interpreter to us of those things which emanate from the air, when it [the brain] happens to be in a sound state.

And yet surely to alchemy this right is due, that it may be compared to the husbandman whereof Æsop makes the fable, that when he died he told his sons that he had left unto them gold buried under the ground in his vineyard: and they digged over the ground, gold they found none, but by reason of their stirring and digging the mould about the roots of their vines, they had a great vintage the year following: so assuredly the search and stir to make gold hath brought to light a great number of good and fruitful inventions and experiments, as well for the disclosing of nature as for the use of man's life.

At a given instant everything the surgeon knows suddenly becomes important to the solution of the problem. You can't do it an hour later, or tomorrow. Nor can you go to the library and look it up.

At first he who invented any art that went beyond the common perceptions of man was naturally admired by men, not only because there was something useful in the inventions, but because he was thought wise and superior to the rest. But as more arts were invented, and some were directed to the necessities of life, others to its recreation, the inventors of the latter were always regarded as wiser than the inventors of the former, because their branches of knowledge did not aim at utility.

Books have always a secret influence on the understanding; we cannot at pleasure obliterate ideas; he that reads books of science, thogh without any fixed desire of improvement, will grow more knowing…

But I do not feel obliged to believe that that same God who has endowed us with senses, reason, and intellect has intended to forgo their use and by some other means to give us knowledge which we can attain by them.

But it must not be forgotten that ... glass and porcelain were manufactured, stuffs dyed and metals separated from their ores by mere empirical processes of art, and without the guidance of correct scientific principles.

But science is the great instrument of social change, all the greater because its object is not change but knowledge, and its silent appropriation of this dominant function, amid the din of political and religious strife, is the most vital of all the revolutions which have marked the development of modern civilisation.

But the greatest error of all the rest is the mistaking or misplacing of the last or farthest end of knowledge: for men have entered into a desire of learning and knowledge, sometimes upon a natural curiosity and inquisitive appetite; sometimes to entertain their minds with variety and delight; sometimes for ornament and reputation; and sometimes to enable them to victory of wit and contradiction; and most times for lucre and profession; and seldom sincerely to give a true account of their gift of reason, to the benefit and use of men...

Chemistry is an art that has furnished the world with a great number of useful facts, and has thereby contributed to the improvement of many arts; but these facts lie scattered in many different books, involved in obscure terms, mixed with many falsehoods, and joined to a great deal of false philosophy; so that it is not great wonder that chemistry has not been so much studied as might have been expected with regard to so useful a branch of knowledge, and that many professors are themselves but very superficially acquainted with it. But it was particularly to be expected, that, since it has been taught in universities, the difficulties in this study should have been in some measure removed, that the art should have been put into form, and a system of it attempted—the scattered facts collected and arranged in a proper order. But this has not yet been done; chemistry has not yet been taught but upon a very narrow plan. The teachers of it have still confined themselves to the purposes of pharmacy and medicine, and that comprehends a small branch of chemistry; and even that, by being a single branch, could not by itself be tolerably explained.

During the century after Newton, it was still possible for a man of unusual attainments to master all fields of scientific knowledge. But by 1800, this had become entirely impracticable. (1965)

Education aims to give you a boost up the ladder of knowledge. Too often, it just gives you a cramp on one of its rungs.

Engineering is not merely knowing and being knowledgeable, like a walking encyclopedia; engineering is not merely analysis; engineering is not merely the possession of the capacity to get elegant solutions to non-existent engineering problems; engineering is practicing the art of the organizing forces of technological change ... Engineers operate at the interface between science and society.

Engineers use knowledge primarily to design, produce, and operate artifacts. … Scientists, by contrast, use knowledge primarily to generate more knowledge.

Even those to whom Providence has allotted greater strength of understanding, can expect only to improve a single science. In every other part of learning, they must be content to follow opinions, which they are not able to examine; and, even in that which they claim as peculiarly their own, can seldom add more than some small particle of knowledge, to the hereditary stock devolved to them from ancient times, the collective labour of a thousand intellects.

Every great advance in natural knowledge has involved the absolute rejection of authority.

Every student who enters upon a scientific pursuit, especially if at a somewhat advanced period of life, will find not only that he has much to learn, but much also to unlearn.

Everywhere science is enriched by unscientific methods and unscientific results, ... the separation of science and non-science is not only artificial but also detrimental to the advancement of knowledge. If we want to understand nature, if we want to master our physical surroundings, then we must use all ideas, all methods, and not just a small selection of them.

Experiment adds to knowledge, Credulity leads to error.

Finally, I aim at giving denominations to things, as agreeable to truth as possible. I am not ignorant that words, like money, possess an ideal value, and that great danger of confusion may be apprehended from a change of names; in the mean time it cannot be denied that chemistry, like the other sciences, was formerly filled with improper names. In different branches of knowledge, we see those matters long since reformed: why then should chemistry, which examines the real nature of things, still adopt vague names, which suggest false ideas, and favour strongly of ignorance and imposition? Besides, there is little doubt but that many corrections may be made without any inconvenience.

First, In showing in how to avoid attempting impossibilities. Second, In securing us from important mistakes in attempting what is, in itself possible, by means either inadequate or actually opposed to the end in view. Thirdly, In enabling us to accomplish our ends in the easiest, shortest, most economical, and most effectual manner. Fourth, In inducing us to attempt, and enabling us to accomplish, object which, but for such knowledge, we should never have thought of understanding.
On the ways that a knowledge of the order of nature can be of use,

For all knowledge and wonder (which is the seed of knowledge) is an impression of pleasure in itself.

For it is owing to their wonder that men now both begin and at first began to philosophize; they wondered originally at the obvious difficulties, then advanced little by little and stated difficulties about the greater matters, e.g. about the phenomena of the moon and those of the sun and the stars, and about the genesis of the universe. And a man who is puzzled and wonders thinks himself ignorant (whence even the lover of myth is in a sense a lover of wisdom, for myth is composed of wonders); therefore since they philosophized in order to escape from ignorance, evidently they were pursuing science in order to know, and not for any utilitarian end. And this is confirmed by the facts; for it was when almost all the necessities of life and the things that make for comfort and recreation were present, that such knowledge began to be sought. Evidently then we do not seek it for the sake of any advantage; but as the man is free, we say, who exists for himself and not for another, so we pursue this as the only free science, for it alone exists for itself.

For most diagnoses all that is needed is an ounce of knowledge, an ounce of intelligence, and a pound of thoroughness.

For the little that one has reflected on the origin of our knowledge, it is easy to perceive that we can acquire it only by means of comparison. That which is absolutely incomparable is wholly incomprehensible. God is the only example that we could give here. He cannot be comprehended, because he cannot be compared. But all which is susceptible of comparison, everything that we can perceive by different aspects, all that we can consider relatively, can always be judged according to our knowledge.

For there are two modes of acquiring knowledge, namely, by reasoning and experience. Reasoning draws a conclusion and makes us grant the conclusion, but does not make the conclusion certain, nor does it remove doubt so that the mind may rest on the intuition of truth, unless the mind discovers it by the path of experience; since many have the arguments relating to what can be known, but because they lack experience they neglect the arguments, and neither avoid what is harmful nor follow what is good. For if a man who has never seen fire should prove by adequate reasoning that fire burns and injures things and destroys them, his mind would not be satisfied thereby, nor would he avoid fire, until he placed his hand or some combustible substance in the fire, so that he might prove by experience that which reasoning taught. But when he has had actual experience of combustion his mind is made certain and rests in the full light of truth. Therefore reasoning does not suffice, but experience does.

Geology holds the keys of one of the kingdoms of nature; and it cannot be said that a science which extends our Knowledge, and by consequence our Power, over a third part of nature, holds a low place among intellectual employments.

However high we climb in the pursuit of knowledge we shall still see heights above us, and the more we extend our view, the more conscious we shall be of the immensity which lies beyond.

Human knowledge and human power meet in one; for where the cause is not known the effect cannot be produced. Nature to be commanded must be obeyed; and that which in contemplation is as the cause is in operation as the rule.

I also maintain that clear knowledge of natural science must be acquired, in the first instance, through mastery of medicine alone.

I devoted myself to studying the texts—the original and commentaries—in the natural sciences and metaphysics, and the gates of knowledge began opening for me. Next I sought to know medicine, and so read the books written on it. Medicine is not one of the difficult sciences, and therefore, I excelled in it in a very short time, to the point that distinguished physicians began to read the science of medicine under me. I cared for the sick and there opened to me some of the doors of medical treatment that are indescribable and can be learned only from practice. In addition I devoted myself to jurisprudence and used to engage in legal disputations, at that time being sixteen years old.

I have accumulated a wealth of knowledge in innumerable spheres and enjoyed it as an always ready instrument for exercising the mind and penetrating further and further. Best of all, mine has been a life of loving and being loved. What a tragedy that all this will disappear with the used-up body!

I have taken all knowledge to be my province.

I have tried to read philosophers of all ages and have found many illuminating ideas but no steady progress toward deeper knowledge and understanding. Science, however, gives me the feeling of steady progress: I am convinced that theoretical physics is actual philosophy. It has revolutionized fundamental concepts, e.g., about space and time (relativity), about causality (quantum theory), and about substance and matter (atomistics), and it has taught us new methods of thinking (complementarity) which are applicable far beyond physics.

I trust and believe that the time spent in this voyage … will produce its full worth in Natural History; and it appears to me the doing what little one can to increase the general stock of knowledge is as respectable an object of life, as one can in any likelihood pursue.

I will frankly tell you that my experience in prolonged scientific investigations convinces me that a belief in God—a God who is behind and within the chaos of vanishing points of human knowledge—adds a wonderful stimulus to the man who attempts to penetrate into the regions of the unknown.

If a man will begin with certainties, he shall end in doubts; but if he will be content to begin with doubts, he shall end in certainties.

If it tends to thicken the crust of ice on which, as it were, we are skating, it is all right. If it tries to find, or professes to have found, the solid ground at the bottom of the water it is all wrong.

If popular medicine gave the people wisdom as well as knowledge, it would be the best protection for scientific and well-trained physicians.

If the human race ever stops acting on the basis of what it thinks it knows, paralyzed by fear that its knowledge may be wrong, then Homo sapiens will be making its application for membership in the dinosaur club.

If the term education may be understood in so large a sense as to include all that belongs to the improvement of the mind, either by the acquisition of the knowledge of others or by increase of it through its own exertions, we learn by them what is the kind of education science offers to man. It teaches us to be neglectful of nothing — not to despise the small beginnings, for they precede of necessity all great things in the knowledge of science, either pure or applied.

If we consider that part of the theory of relativity which may nowadays in a sense be regarded as bone fide scientific knowledge, we note two aspects which have a major bearing on this theory. The whole development of the theory turns on the question of whether there are physically preferred states of motion in Nature (physical relativity problem). Also, concepts and distinctions are only admissible to the extent that observable facts can be assigned to them without ambiguity (stipulation that concepts and distinctions should have meaning). This postulate, pertaining to epistemology, proves to be of fundamental importance.

If we would serve science, we must extend her limits, not only as far as our own knowledge is concerned, but in the estimation of others.

Ignorance more frequently begets confidence than does knowledge: it is those who know little, and not those who know much, who so positively assert that this or that problem will never be solved by science

In formal logic a contradiction is the signal of a defeat, but in the evolution of real knowledge it marks the first step in progress toward a victory.

In no subject is there a rule, compliance with which will lead to new knowledge or better understanding. Skilful observations, ingenious ideas, cunning tricks, daring suggestions, laborious calculations, all these may be required to advance a subject. Occasionally the conventional approach in a subject has to be studiously followed; on other occasions it has to be ruthlessly disregarded. Which of these methods, or in what order they should be employed is generally unpredictable. Analogies drawn from the history of science are frequently claimed to be a guide; but, as with forecasting the next game of roulette, the existence of the best analogy to the present is no guide whatever to the future. The most valuable lesson to be learnt from the history of scientific progress is how misleading and strangling such analogies have been, and how success has come to those who ignored them.

In science, attempts at formulating hierarchies are always doomed to eventual failure. A Newton will always be followed by an Einstein, a Stahl by a Lavoisier; and who can say who will come after us? What the human mind has fabricated must be subject to all the changes—which are not progress—that the human mind must undergo. The 'last words' of the sciences are often replaced, more often forgotten. Science is a relentlessly dialectical process, though it suffers continuously under the necessary relativation of equally indispensable absolutes. It is, however, possible that the ever-growing intellectual and moral pollution of our scientific atmosphere will bring this process to a standstill. The immense library of ancient Alexandria was both symptom and cause of the ossification of the Greek intellect. Even now I know of some who feel that we know too much about the wrong things.

In science, probably ninety-nine percent of the knowable has to be discovered. We know only a few streaks about astronomy. We are only beginning to imagine the force and composition of the atom. Physics has not yet found any indivisible matter…

In the final, the positive, state, the mind has given over the vain search after absolute notions, the origin and destination of the universe, and the causes of phenomena, and applies itself to the study of their laws—that is, their invariable relations of succession and resemblance. Reasoning and observation, duly combined, are the means of this knowledge. What is now understood when we speak of an explanation of facts is simply the establishment of a connection between single phenomena and some general facts.

In the natural sciences, and particularly in chemistry, generalities must come after the detailed knowledge of each fact and not before it.

In this age of space flight, when we use the modern tools of science to advance into new regions of human activity, the Bible ... this grandiose, stirring history of the gradual revelation and unfolding of the moral law ... remains in every way an up-to-date book. Our knowledge and use of the laws of nature that enable us to fly to the Moon also enable us to destroy our home planet with the atom bomb. Science itself does not address the question whether we should use the power at our disposal for good or for evil. The guidelines of what we ought to do are furnished in the moral law of God. It is no longer enough that we pray that God may be with us on our side. We must learn again that we may be on God's side.

Inductive inference is the only process known to us by which essentially new knowledge comes into the world.

Industrial Society is not merely one containing 'industry,' large-scale productive units capable of supplying man's material needs in a way which can eliminate poverty: it is also a society in which knowledge plays a part wholly different from that which it played in earlier social forms, and which indeed possesses a quite different type of knowledge. Modern science is inconceivable outside an industrial society: but modern industrial society is equally inconceivable without modern science. Roughly, science is the mode of cognition of industrial society, and industry is the ecology of science.

Information is not knowledge, knowledge is not wisdom, and wisdom is not foresight. Each grows out of the other, and we need them all.

Isolated facts and experiments have in themselves no value, however great their number may be. They only become valuable in a theoretical or practical point of view when they make us acquainted with the law of a series of uniformly recurring phenomena, or, it may be, only give a negative result showing an incompleteness in our knowledge of such a law, till then held to be perfect.

It is almost as difficult to make a man unlearn his errors, as his knowledge. Mal-information is more hopeless than non-information: for error is always more busy than ignorance. Ignorance is a blank sheet on which we may write; but error is a scribbled one on which we first erase. Ignorance is contented to stand still with her back to the truth; but error is more presumptuous, and proceeds, in the same direction. Ignorance has no light, but error follows a false one. The consequence is, that error, when she retraces her footsteps, has farther to go, before we can arrive at the truth, than ignorance.

It is not knowledge, but the act of learning, not possession but the act of getting there, which grants the greatest enjoyment. When I have clarified and exhausted a subject, then I turn away from it, in order to go into darkness again; the never-satisfied man is so strange if he has completed a structure, then it is not in order to dwell in it peacefully,but in order to begin another. I imagine the world conqueror must feel thus, who, after one kingdom is scarcely conquered, stretches out his arms for others.

It is not what we know that is important, it is what we do not know.

It is only those who know a little of nature, who fancy they know much. I have heard a young man say, after hearing a few popular chemical lectures, and seeing a few bottle and squirt experiments: Oh, water—water is only oxygen and hydrogen!—as if he knew all about it. While the true chemist would smile sadly enough at the the youth's hasty conceit, and say in his heart: 'Well, he is a lucky fellow.'

It is the responsibility of scientists never to suppress knowledge, no matter how awkward that knowledge is, no matter how it may bother those in power; we are not smart enough to decide which pieces of knowledge are permissible, and which are not. …

It is they [men of science] who hold the secret of the mysterious property of the mind by which error ministers to truth, and truth slowly but irrevocably prevails. Theirs is the logic of discovery, the demonstration of the advance of knowledge and the development of ideas, which as the earthly wants and passions of men remain almost unchanged, are the charter of progress, and the vital spark in history.

It might be said that all knowledge is linked to the essential forms of cruelty.

It must be conceded that a theory has an important advantage if its basic concepts and fundamental hypotheses are 'close to experience,' and greater confidence in such a theory is certainly justified. There is less danger of going completely astray, particularly since it takes so much less time and effort to disprove such theories by experience. Yet more and more, as the depth of our knowledge increases, we must give up this advantage in our quest for logical simplicity in the foundations of physical theory...

It was the secrets of heaven and earth that I desired to learn.

It will be contributing to bring forward the moment in which, seeing clearer into the nature of things, and having learnt to distinguish real knowledge from what has only the appearance of it, we shall be led to seek for exactness in every thing.

Knowing is not understanding. There is a great difference between knowing and understanding: you can know a lot about something and not really understand it.

Knowledge and ability must be combined with ambition as well as with a sense of honesty and a severe conscience. Every analyst occasionally has doubts about the accuracy of his results, and also there are times when he knows his results to be incorrect. Sometimes a few drops of the solution were spilt, or some other slight mistake made. In these cases it requires a strong conscience to repeat the analysis and to make a rough estimate of the loss or apply a correction. Anyone not having sufficient will-power to do this is unsuited to analysis no matter how great his technical ability or knowledge. A chemist who would not take an oath guaranteeing the authenticity, as well as the accuracy of his work, should never publish his results, for if he were to do so, then the result would be detrimental not only to himself, but to the whole of science.

Knowledge is a process of piling up facts; wisdom lies in their simplification.

Knowledge is not happiness, and science but an exchange of ignorance for that which is another kind of ignorance.

Knowledge is proud that he has learn'd so much; Wisdom is humble that he knows no more.

Knowledge must be gained by ourselves. Mankind may supply us with facts; but the results, even if they agree with previous ones, must be the work of our own minds.

Knowledge of Nature is an account at bank, where each dividend is added to the principal and the interest is ever compounded; and hence it is that human progress, founded on natural knowledge, advances with ever increasing speed.

Knowledge—it excites prejudices to call it science—is advancing as irresistibly, as majestically, as remorselessly as the ocean moves in upon the shore.

Learn the leading precognita of all things—no need to turn over leaf by leaf, but grasp the trunk hard and you will shake all the branches.
Advice cherished by Samuel Johnson that that, if one is to master any subject, one must first discover its general principles.

Let us see how high we can fly before the sun melts the wax in our wings.
About the ambitious pursuit of knowledge, alluding to Icarus of the Greek myth.

Let us suppose the mind to be, as we say, white paper, void of all characters, without any ideas; how comes it to be furnished? Whence comes it by that vast store which the busy and boundless fancy of man has painted on it with an almost endless variety? Whence has it all the materials of reason and knowledge? To this I answer, in one word, from experience.

Man cannot have an effect on nature, cannot adopt any of her forces, if he does not know the natural laws in terms of measurement and numerical relations. Here also lies the strength of the national intelligence, which increases and decreases according to such knowledge. Knowledge and comprehension are the joy and justification of humanity; they are parts of the national wealth, often a replacement for the materials that nature has too sparcely dispensed. Those very people who are behind us in general industrial activity, in application and technical chemistry, in careful selection and processing of natural materials, such that regard for such enterprise does not permeate all classes, will inevitably decline in prosperity; all the more so were neighbouring states, in which science and the industrial arts have an active interrelationship, progress with youthful vigour.

Man has an intense desire for assured knowledge.

Man, being the servant and interpreter of Nature, can do and understand so much and so much only as he has observed in fact or thought of the course of nature; beyond this he neither knows anything nor can do anything.

Mathematical knowledge adds a manly vigour to the mind, frees it from prejudice, credulity, and superstition.

Modern civilization depends on science … James Smithson was well aware that knowledge should not be viewed as existing in isolated parts, but as a whole, each portion of which throws light on all the other, and that the tendency of all is to improve the human mind, and give it new sources of power and enjoyment … narrow minds think nothing of importance but their own favorite pursuit, but liberal views exclude no branch of science or literature, for they all contribute to sweeten, to adorn, and to embellish life … science is the pursuit above all which impresses us with the capacity of man for intellectual and moral progress and awakens the human intellect to aspiration for a higher condition of humanity.
[Joseph Henry was the first Secretary of the Smithsonian Institution, named after its benefactor, James Smithson. The first phrase is inscribed on the National Museum of American History, Washington, D.C.]

Much is said about the progress of science in these centuries. I should say that the useful results of science had accumulated, but that there had been no accumulation of knowledge, strictly speaking, for posteriry; for knowledge is to be aquired only by corresponding experience. How can be know what we are told merely? Each man can interpret another's experience only by his own.

Never any knowledge was delivered in the same order it was invented.

No man of science wants merely to know. He acquires knowledge to appease his passion for discovery. He does not discover in order to know, he knows in order to discover.

No one has yet been found so firm of mind and purpose as resolutely to compel himself to sweep away all theories and common notions, and to apply the understanding, thus made fair and even, to a fresh examination of particulars. Thus it happens that human knowledge, as we have it, is a mere medley and ill-digested mass, made up of much credulity and much accident, and also of the childish notions which we at first imbibed.

No part of the world can be truly understood without a knowledge of its garment of vegetation, for this determines not only the nature of the animal inhabitants but also the occupations of the majority of human beings.

Nothing is known in our profession by guess; and I do not believe, that from the first dawn of medical science to the present moment, a single correct idea has ever emanated from conjecture: it is right therefore, that those who are studying their profession should be aware that there is no short road to knowledge; and that observation on the diseased living, examination of the dead, and experiments upon living animals, are the only sources of true knowledge; and that inductions from these are the sole bases of legitimate theory.

Nothing tends so much to the advancement of knowledge as the application of a new instrument.

Now, in the development of our knowledge of the workings of Nature out of the tremendously complex assemblage of phenomena presented to the scientific inquirer, mathematics plays in some respects a very limited, in others a very important part. As regards the limitations, it is merely necessary to refer to the sciences connected with living matter, and to the ologies generally, to see that the facts and their connections are too indistinctly known to render mathematical analysis practicable, to say nothing of the complexity. Facts are of not much use, considered as facts. They bewilder by their number and their apparent incoherency. Let them be digested into theory, however, and brought into mutual harmony, and it is another matter. Theory is the essence of facts. Without theory scientific knowledge would be only worthy of the madhouse.

Of power does Man possess no particle:
Of knowledge—just so much as show that still
It ends in ignorance on every side…

One and all
We lend an ear—nay, Science takes thereto—
Encourages the meanest who has racked
Nature until he gains from her some fact,
To state what truth is from his point of view,
Mere pin-point though it be: since many such
Conduce to make a whole, she bids our friend
Come forward unabashed and haply lend
His little life-experience to our much
Of modern knowledge.

One of the great problems of philosophy, is the relationship between the realm of knowledge and the realm of values. Knowledge is what is; values are what ought to be. I would say that all traditional philosophies up to and including Marxism have tried to derive the 'ought' from the 'is.' My point of view is that this is impossible, this is a farce.

Only those works which are well-written will pass to posterity: the amount of knowledge, the uniqueness of the facts, even the novelty of the discoveries are no guarantees of immortality ... These things are exterior to a man but style is the man himself.

Philosophy is that part of science which at present people chose to have opinions about, but which they have no knowledge about. Therefore every advance in knowledge robs philosophy of some problems which formerly it had …and will belong to science.

Positivism stands or falls with the principle of scientism, that is that the meaning of knowledge is defined by what the sciences do and can thus be adequately explicated through the methodological analysis of scientific procedures.

Remember that accumulated knowledge, like accumulated capital, increases at compound interest: but it differs from the accumulation of capital in this; that the increase of knowledge produces a more rapid rate of progress, whilst the accumulation of capital leads to a lower rate of interest. Capital thus checks its own accumulation: knowledge thus accelerates its own advance. Each generation, therefore, to deserve comparison with its predecessor, is bound to add much more largely to the common stock than that which it immediately succeeds.

Science ... in other words, knowledge—is not the enemy of religion; for, if so, then religion would mean ignorance. But it is often the antagonist of school-divinity.

Science begets knowledge; opinion, ignorance.

Science investigates; religion interprets. Science gives man knowledge which is power; region gives man wisdom which is control. Science deals mainly with facts; religion deals mainly with values. The two are not rivals. They are complementary.

Science is a progressive activity. The outstanding peculiarity of man is that he stumbled onto the possibility of progressive activities. Such progress, the accumulation of experience from generation to generation, depended first on the development of language, then of writing and finally of printing. These allowed the accumulation of tradition and of knowledge, of the whole aura of cultural inheritance that surrounds us. This has so conditioned our existence that it is almost impossible for us to stop and examine the nature of our culture. We accept it as we accept the air we breathe; we are as unconscious of our culture as a fish, presumably, is of water.

Science is best defined as a careful, disciplined, logical search for knowledge about any and all aspects of the universe, obtained by examination of the best available evidence and always subject to correction and improvement upon discovery of better evidence. What's left is magic. And it doesn't work.

Science is organized knowledge. Wisdom is organized life.

Science is the knowledge of constant things, not merely of passing events, and is properly less the knowledge of general laws than of existing facts.

Scientific discovery and scientific knowledge have been achieved only by those who have gone in pursuit of them without any practical purpose whatsoever in view.

Scientific knowledge advances haltingly and is stimulated by contention and doubt.

Scientific modes of thought cannot be developed and become generally accepted unless people renounce their primary, unreflecting, and spontaneous attempt to understand all their experience in terms of its purpose and meaning for themselves. The development that led to more adequate knowledge and increasing control of nature was therefore, considered from one aspect, also a development toward greater self-control by men.

Statistics, one may hope, will improve gradually, and become good for something. Meanwhile, it is to be feared the crabbed satirist was partly right, as things go: 'A judicious man,' says he, 'looks at Statistics, not to get knowledge, but to save himself from having ignorance foisted on him.'

That knowledge is not happiness, and science
But an exchange of ignorance for that
Which is another kind of ignorance.

That our knowledge only illuminates a small corner of the Universe, that it is incomplete, approximate, tentative and merely probable need not concert us. It is genuine nevertheless. Physical science stands as one of the great achievements of the human spirit.

The advance of scientific knowledge does not seem to make either our universe or our inner life in it any less mysterious.

The bent of our time is towards science, towards knowing things as they are …

The End of our Foundation is the knowledge of Causes; and secret motions of things; and the enlarging of the bounds of Human Empire, to the effecting of all things possible.

The engineer is the key figure in the material progress of the world. It is his engineering that makes a reality of the potential value of science by translating scientific knowledge into tools, resources, energy and labor to bring them to the service of man ... To make contribution of this kind the engineer requires the imagination to visualize the needs of society and to appreciate what is possible as well as the technological and broad social age understanding to bring his vision to reality.

The examination system, and the fact that instruction is treated mainly as a training for a livelihood, leads the young to regard knowledge from a purely utilitarian point of view as the road to money, not as the gateway to wisdom.

The first business of a man of science is to proclaim the truth as he finds it, and let the world adjust itself as best it can to the new knowledge.

The first thing the reasonable man must do is to be content with a very little knowledge and a very great deal of ignorance. The second thing he must do is to make the utmost possible use of the knowledge he has and not waste his energy crying for the moon. The third thing he must do is try and see clearly where his knowledge ends and his ignorance begins.

The Fox knows many things—the hedgehog one big one.

The growth of our knowledge is the result of a process closely resembling what Darwin called 'natural selection'; that is, the natural selection of hypotheses: our knowledge consists, at every moment, of those hypotheses which have shown their (comparative) fitness by surviving so far in their struggle for existence, a competitive struggle which eliminates those hypotheses which are unfit.

The law is this: that each of our leading conceptions—each branch of our knowledge—passes successively through three different theoretical conditions: the Theological, or fictitious: the Metaphysical, or abstract; and the Scientific, or positive.

The man of perfect knowledge should not unsettle the foolish whose knowledge is imperfect.

The mind can proceed only so far upon what it knows and can prove. There comes a point where the mind takes a higher plane of knowledge, but can never prove how it got there. All great discoveries have involved such a leap

The only fence against the world is a thorough knowledge of it.

The partitions of knowledge are not like several lines that meet in one angle, and so touch not in a point; but are like branches of a tree, that meet in a stem, which hath a dimension and quantity of entireness and continuance, before it come to discontinue and break itself into arms and boughs.

The Principle of Uncertainty is a bad name. In science or outside of it we are not uncertain; our knowledge is merely confined, within a certain tolerance. We should call it the Principle of Tolerance. And I propose that name in two senses: First, in the engineering sense, science has progressed, step by step, the most successful enterprise in the ascent of man, because it has understood that the exchange of information between man and nature, and man and man, can only take place with a certain tolerance. But second, I also use the word, passionately, about the real world. All knowledge, all information between human beings, can only be exchanged within a play of tolerance. And that is true whether the exchange is in science, or in literature, or in religion, or in politics, or in any form of thought that aspires to dogma. It's a major tragedy of my lifetime and yours that scientists were refining, to the most exquisite precision, the Principle of Tolerance, and turning their backs on the fact that all around them, tolerance was crashing to the ground beyond repair. The Principle of Uncertainty or, in my phrase, the Principle of Tolerance, fixed once for all the realization that all knowledge is limited. It is an irony of history that at the very time when this was being worked out there should rise, under Hitler in Germany and other tyrants elsewhere, a counter-conception: a principle of monstrous certainty. When the future looks back on the 1930s it will think of them as a crucial confrontation of culture as I have been expounding it, the ascent of man, against the throwback to the despots' belief that they have absolute certainty. It is said that science will dehumanize people and turn them into numbers. That is false: tragically false. Look for yourself. This is the concentration camp and crematorium at Auschwitz. This is where people were turned into numbers. Into this pond were flushed the ashes of four million people. And that was not done by gas. It was done by arrogance. It was done by dogma. It was done by ignorance. When people believe that they have absolute knowledge, with no test in realitythis is how they behave. This is what men do when they aspire to the knowledge of gods. Science is a very human form of knowledge. We are always at the brink of the known; we always feel forward for what is to be hoped. Every judgment in science stands on the edge of error, and is personal. Science is a tribute to what we can know although we are fallible. In the end, the words were said by Oliver Cromwell: 'I beseech you, in the bowels of Christ: Think it possible you may be mistaken.' We have to cure ourselves of the itch for absolute knowledge and power. We have to close the distance between the push-button order and the human