A discovery must be, by definition, at variance with existing knowledge. During my lifetime, I made two. Both were rejected offhand by the popes of the field. Had I predicted these discoveries in my applications, and had those authorities been my judges, it is evident what their decisions would have been.

All Pretences of foretelling by Astrology, are Deceits; for this manifest Reason, because the Wise and Learned, who can only judge whether there be any Truth in this Science, do all unanimously agree to laugh at and despise it; and none but the poor ignorant Vulgar give it any Credit.

If this “critical openminded attitude” ... is wanted, the question at once arises, Is it science that should be studied in order to achieve it? Why not study law? A judge has to do everything that a scientist is exhorted to do in the way of withholding judgment until all the facts are in, and then judging impartially on the merits of the case as well as he can.... Why not a course in Sherlock Holmes? The detectives, or at least the detective-story writers, join with the scientists in excoriating "dogmatic prejudice, lying, falsification of facts, and data, and willful fallacious reasoning."

Know then thyself, presume not God to scan;
The proper study of Mankind is Man.
Plac'd on this isthmus of a middle state,
A being darkly wise, and rudely great:
With too much knowledge for the Sceptic side,
With too much weakness for the Stoic's pride,
He hangs between; in doubt to act, or rest;
In doubt to deem himself a God, or Beast;
In doubt his Mind or Body to prefer,
Born but to die, and reas'ning but to err;
Alike in ignorance, his reason such,
Whether he thinks too little, or too much:
Chaos of Thought and Passion, all confus'd;
Still by himself abus'd, or disabus'd;
Created half to rise, and half to fall;
Great lord of all things, yet a prey to all;
Sole judge of Truth, in endless Error hurl'd:
The glory, jest, and riddle of the world!
... Superior beings, when of late they saw
A mortal Man unfold all Nature's law,
Admir'd such wisdom in an earthly shape,
And shew'd a NEWTON as we shew an Ape.

Not greatly moved with awe am I
To learn that we may spy
Five thousand firmaments beyond our own.
The best that's known
Of the heavenly bodies does them credit small.
View'd close, the Moon's fair ball
Is of ill objects worst,
A corpse in Night's highway, naked, fire-scarr'd, accurst;
And now they tell
That the Sun is plainly seen to boil and burst
Too horribly for hell.
So, judging from these two,
As we must do,
The Universe, outside our living Earth,
Was all conceiv'd in the Creator's mirth,
Forecasting at the time Man's spirit deep,
To make dirt cheap.
Put by the Telescope!
Better without it man may see,
Stretch'd awful in the hush'd midnight,
The ghost of his eternity.

Only the doctor and the judge have the right to inflict the death penalty without receiving the same.

Reason must approach nature with the view, indeed, of receiving information from it, not, however, in the character of a pupil, who listens to all that his master chooses to tell him, but in that of a judge, who compels the witnesses to reply to those questions which he himself thinks fit to propose. To this single idea must the revolution be ascribed, by which, after groping in the dark for so many centuries, natural science was at length conducted into the path of certain progress.

The generality of men are so accustomed to judge of things by their senses that, because the air is indivisible, they ascribe but little to it, and think it but one remove from nothing.

The republic has no need of scientists [savants].
Apocryphal remark; supposedly the judge's reply to Lavoisier when he appealed at his trial for more time to complete his scientific work.

We must in imagination sweep off the drifted matter that clogs the surface of the ground; we must suppose all the covering of moss and heath and wood to be torn away from the sides of the mountains, and the green mantle that lies near their feet to be lifted up; we may then see the muscular integuments, and sinews, and bones of our mother Earth, and so judge of the part played by each of them during those old convulsive movements whereby her limbs were contorted and drawn up into their present posture.