Any artist or novelist would understand—some of us do not produce their best when directed. We expect the artist, the novelist and the composer to lead solitary lives, often working at home. While a few of these creative individuals exist in institutions or universities, the idea of a majority of established novelists or painters working at the 'National Institute for Painting and Fine Art' or a university 'Department of Creative Composition' seems mildly amusing. By contrast, alarm greets the idea of a creative scientist working at home. A lone scientist is as unusual as a solitary termite and regarded as irresponsible or worse.

I am particularly concerned to determine the probability of causes and results, as exhibited in events that occur in large numbers, and to investigate the laws according to which that probability approaches a limit in proportion to the repetition of events. That investigation deserves the attention of mathematicians because of the analysis required. It is primarily there that the approximation of formulas that are functions of large numbers has its most important applications. The investigation will benefit observers in identifying the mean to be chosen among the results of their observations and the probability of the errors still to be apprehended. Lastly, the investigation is one that deserves the attention of philosophers in showing how in the final analysis there is a regularity underlying the very things that seem to us to pertain entirely to chance, and in unveiling the hidden but constant causes on which that regularity depends. It is on the regularity of the main outcomes of events taken in large numbers that various institutions depend, such as annuities, tontines, and insurance policies. Questions about those subjects, as well as about inoculation with vaccine and decisions of electoral assemblies, present no further difficulty in the light of my theory. I limit myself here to resolving the most general of them, but the importance of these concerns in civil life, the moral considerations that complicate them, and the voluminous data that they presuppose require a separate work.

The patent system was established, I believe, to protect the lone inventor. In this it has not succeeded. … The patent system protects the institutions which favor invention

The progress of science is often affected more by the frailties of humans and their institutions than by the limitations of scientific measuring devices. The scientific method is only as effective as the humans using it. It does not automatically lead to progress.

We are at that very point in time when a four-hundred-year-old age is rattling in its deathbed and another is struggling to be born. A shifting of culture, science, society and institutions enormously greater and swifter than the world has ever experienced. Ahead, lies the possibility of regeneration of individuality, liberty, community and ethics such as the world has never known, and a harmony with nature, with one another and with the divine intelligence such as the world has always dreamed.