Any opinion as to the form in which the energy of gravitation exists in space is of great importance, and whoever can make his opinion probable will have, made an enormous stride in physical speculation. The apparent universality of gravitation, and the equality of its effects on matter of all kinds are most remarkable facts, hitherto without exception; but they are purely experimental facts, liable to be corrected by a single observed exception. We cannot conceive of matter with negative inertia or mass; but we see no way of accounting for the proportionality of gravitation to mass by any legitimate method of demonstration. If we can see the tails of comets fly off in the direction opposed to the sun with an accelerated velocity, and if we believe these tails to be matter and not optical illusions or mere tracks of vibrating disturbance, then we must admit a force in that direction, and we may establish that it is caused by the sun if it always depends upon his position and distance.

Art and religion first; then philosophy; lastly science. That is the order of the great subjects of life, that’s their order of importance.

But the life of a man is of no greater importance to the universe than that of an oyster.

Darwin's book is very important and serves me as a basis in natural science for the class struggle in history. One has to put up with the crude English method of development, of course. Despite all deficiencies not only is the death-blow dealt here for the first time to 'teleology' in the natural sciences, but their rational meaning is empirically explained.

Each generation has its few great mathematicians, and mathematics would not even notice the absence of the others. They are useful as teachers, and their research harms no one, but it is of no importance at all. A mathematician is great or he is nothing.

Here I shall present, without using Analysis [mathematics], the principles and general results of the Théorie, applying them to the most important questions of life, which are indeed, for the most part, only problems in probability. One may even say, strictly speaking, that almost all our knowledge is only probable; and in the small number of things that we are able to know with certainty, in the mathematical sciences themselves, the principal means of arriving at the truth—induction and analogy—are based on probabilities, so that the whole system of human knowledge is tied up with the theory set out in this essay.

If Watson and I had not discovered the [DNA] structure, instead of being revealed with a flourish it would have trickled out and that its impact would have been far less. For this sort of reason Stent had argued that a scientific discovery is more akin to a work of art than is generally admitted. Style, he argues, is as important as content. I am not completely convinced by this argument, at least in this case.

It is more important to know the properties of chlorine than the improprieties of Claudius!

Man is a little germ that lives on an unimportant rock ball that revolves about a small star at the outskirts of an ordinary galaxy. ... I am absolutely amazed to discover myself on this rock ball rotating around a spherical fire. It’s a very odd situation. And the more I look at things I cannot get rid of the feeling that existence is quite weird.

The major credit I think Jim and I deserve ... is for selecting the right problem and sticking to it. It's true that by blundering about we stumbled on gold, but the fact remains that we were looking for gold. Both of us had decided, quite independently of each other, that the central problem in molecular biology was the chemical structure of the gene. ... We could not see what the answer was, but we considered it so important that we were determined to think about it long and hard, from any relevant point of view.

This missing science of heredity, this unworked mine of knowledge on the borderland of biology and anthropology, which for all practical purposes is as unworked now as it was in the days of Plato, is, in simple truth, ten times more important to humanity than all the chemistry and physics, all the technical and indsutrial science that ever has been or ever will be discovered.

Uniformity in the currency, weights, and measures of the United States is an object of great importance, and will, I am persuaded, be duly attended to.

[Magic] enables man to carry out with confidence his important tasks, to maintain his poise and his mental integrity in fits of anger, in the throes of hate, of unrequited love, of despair and anxiety. The function of magic is to ritualize man's optimism, to enhance his faith in the victory of hope over fear. Magic expresses the greater value for man of confidence over doubt, of steadfastness over vacillation, of optimism over pessimism.

[Science] is the literature of God written on the stars—the trees—the rocks—and more important because [of] its marked utilitarian character.