A science which hesitates to forget its founders is lost.

The reduced variability of small populations is not always due to accidental gene loss, but sometimes to the fact that the entire population was started by a single pair or by a single fertilized female. These 'founders' of the population carried with them only a very small proportion of the variability of the parent population. This 'founder' principle sometimes explains even the uniformity of rather large populations, particularly if they are well isolated and near the borders of the range of the species.

What the founders of modern science, among them Galileo, had to do, was not to criticize and to combat certain faulty theories, and to correct or to replace them by better ones. They had to do something quite different. They had to destroy one world and to replace it by another. They had to reshape the framework of our intellect itself, to restate and to reform its concepts, to evolve a new approach to Being, a new concept of knowledge, a new concept of science—and even to replace a pretty natural approach, that of common sense, by another which is not natural at all.