Imprimisque hominis est propria veri inquisitio atque investigatio.
The first duty of man is the seeking after and the investigation of truth.

All of today's DNA, strung through all the cells of the earth, is simply an extension and elaboration of [the] first molecule.

Electricity is but yet a new agent for the arts and manufactures, and, doubtless, generations unborn will regard with interest this century, in which it has been first applied to the wants of mankind.

Entropy theory is indeed a first attempt to deal with global form; but it has not been dealing with structure. All it says is that a large sum of elements may have properties not found in a smaller sample of them.

Freedom, the first-born of science.

Genius always gives its best at first, prudence at last.

He who thus considers things in their first growth and origin ... will obtain the clearest view of them.

I can assure you, reader, that in a very few hours, even during the first day, you will learn more natural philosophy about things contained in this book, than you could learn in fifty years by reading the theories and opinions of the ancient philosophers. Enemies of science will scoff at the astrologers: saying, where is the ladder on which they have climbed to heaven, to know the foundation of the stars? But in this respect I am exempt from such scoffing; for in proving my written reason, I satisfy sight, hearing, and touch: for this reason, defamers will have no power over me: as you will see when you come to see me in my little Academy.

I think she [Rosalind Franklin] was a good experimentalist but certainly not of the first rank. She was simply not in the same class as Eigen or Bragg or Pauling, nor was she as good as Dorothy Hodgkin. She did not even select DNA to study. It was given to her. Her theoretical crystallography was very average.

If at first you don’t succeed, try, try, try again.

In the discovery of lemmas the best aid is a mental aptitude for it. For we may see many who are quick at solutions and yet do not work by method ; thus Cratistus in our time was able to obtain the required result from first principles, and those the fewest possible, but it was his natural gift which helped him to the discovery.

It is a common observation that a science first begins to be exact when it is quantitatively treated. What are called the exact sciences are no others than the mathematical ones.

James Watt patented his steam engine on the eve of the American Revolution, consummating a relationship between coal and the new Promethean spirit of the age, and humanity made its first tentative steps into an industrial way of life that would, over the next two centuries, forever change the world.

Look around when you have got your first mushroom or made your first discovery: they grow in clusters.

My belief (is) that one should take a minimum of care and preparation over first experiments. If they are unsuccessful one is not then discouraged since many possible reasons for failure can be thought of, and improvements can be made. Much can often be learned by the repetition under different conditions, even if the desired result is not obtained. If every conceivable precaution is taken at first, one is often too discouraged to proceed at all.

One of the first and foremost duties of the teacher is not to give his students the impression that mathematical problems have little connection with each other, and no connection at all with anything else. We have a natural opportunity to investigate the connections of a problem when looking back at its solution.

Physio-philosophy has to show how, and in accordance indeed with what laws, the Material took its origin; and, therefore, how something derived its existence from nothing. It has to portray the first periods of the world's development from nothing; how the elements and heavenly bodies originated; in what method by self-evolution into higher and manifold forms, they separated into minerals, became finally organic, and in Man attained self-consciousness.

Psychogenesis has led to man. Now it effaces itself, relieved or absorbed by another and a higher function—the engendering and subsequent development of the mind, in one word noogenesis. When for the first time in a living creature instinct perceived itself in its own mirror, the whole world took a pace forward.

Science knows no country because knowledge belongs to humanity, and is the torch which illuminates the world. Science is the highest personification of the nation because that nation will remain the first which carries the furthest the works of thought and intelligence.

The first and last thing which is required of genius is the love of truth.

The first experiment a child makes is a physical experiment: the suction-pump is but an imitation of the first act of every new-born infant.

The human mind has first to construct forms, independently, before we can find them in things.

The laws expressing the relations between energy and matter are, however, not solely of importance in pure science. They necessarily come first in order ... in the whole record of human experience, and they control, in the last resort, the rise or fall of political systems, the freedom or bondage of nations, the movements of commerce and industry, the origin of wealth and poverty, and the general physical welfare of the race.

The puritanical potentialities of science have never been forecast. If it evolves a body of organized rites, and is established as a religion, hierarchically organized, things more than anything else will be done in the name of 'decency.' The coarse fumes of tobacco and liquors, the consequent tainting of the breath and staining of white fingers and teeth, which is so offensive to many women, will be the first things attended to.

The starting point of Darwin's theory of evolution is precisely the existence of those differences between individual members of a race or species which morphologists for the most part rightly neglect. The first condition necessary, in order that any process of Natural Selection may begin among a race, or species, is the existence of differences among its members; and the first step in an enquiry into the possible effect of a selective process upon any character of a race must be an estimate of the frequency with which individuals, exhibiting any given degree of abnormality with respect to that, character, occur. The unit, with which such an enquiry must deal, is not an individual but a race, or a statistically representative sample of a race; and the result must take the form of a numerical statement, showing the relative frequency with which the various kinds of individuals composing the race occur.

There is a popular cliché ... which says that you cannot get out of computers any more than you have put in..., that computers can only do exactly what you tell them to, and that therefore computers are never creative. This cliché is true only in a crashingly trivial sense, the same sense in which Shakespeare never wrote anything except what his first schoolteacher taught him to write—words.

There is only one law of Nature—the second law of thermodynamics—which recognises a distinction between past and future more profound than the difference of plus and minus. It stands aloof from all the rest. ... It opens up a new province of knowledge, namely, the study of organisation; and it is in connection with organisation that a direction of time-flow and a distinction between doing and undoing appears for the first time.

Without the slightest doubt there is something through which material and spiritual energy hold togehter and are complementary. In the last analysis, somehow or other, there must be a single energy operating in the world. And the first idea that occurs to us is that the 'soul' must be as it were the focal point of transformation at which, from all the points of nature, the forces of bodies converge, to become interiorised and sublimated in beauty and truth.