“I'm not so sure he's wrong about automobiles,” he said, “With all their speed forward they may be a step backward for civilization—that is, spiritual civilization ... But automobiles have come, and they bring a greater change in our life than most of us expect. They are here, and almost all outward things are going to be different because of what they bring. They are going to alter war, and they are going to alter peace.”

“Science studies everything,” say the scientists. But, really, everything is too much. Everything is an infinite quantity of objects; it is impossible at one and the same time to study all. As a lantern cannot light up everything, but only lights up the place on which it is turned or the direction in which the man carrying it is walking, so also science cannot study everything, but inevitably only studies that to which its attention is directed. And as a lantern lights up most strongly the place nearest to it, and less and less strongly objects that are more and more remote from it, and does not at all light up those things its light does not reach, so also human science, of whatever kind, has always studied and still studies most carefully what seems most important to the investigators, less carefully what seems to them less important, and quite neglects the whole remaining infinite quantity of objects. ... But men of science to-day ... have formed for themselves a theory of “science for science's sake,” according to which science is to study not what mankind needs, but everything.

Question: State the relations existing between the pressure, temperature, and density of a given gas. How is it proved that when a gas expands its temperature is diminished?
Answer: Now the answer to the first part of this question is, that the square root of the pressure increases, the square root of the density decreases, and the absolute temperature remains about the same; but as to the last part of the question about a gas expanding when its temperature is diminished, I expect I am intended to say I don't believe a word of it, for a bladder in front of a fire expands, but its temperature is not at all diminished.

[About Francis Baily] The history of the astronomy of the nineteenth century will be incomplete without a catalogue of his labours. He was one of the founders of the Astronomical Society, and his attention to its affairs was as accurate and minute as if it had been a firm of which he was the chief clerk, with expectation of being taken into partnership.

A plain, reasonable working man supposes, in the old way which is also the common-sense way, that if there are people who spend their lives in study, whom he feeds and keeps while they think for him—then no doubt these men are engaged in studying things men need to know; and he expects of science that it will solve for him the questions on which his welfare, and that of all men, depends. He expects science to tell him how he ought to live: how to treat his family, his neighbours and the men of other tribes, how to restrain his passions, what to believe in and what not to believe in, and much else. And what does our science say to him on these matters?
It triumphantly tells him: how many million miles it is from the earth to the sun; at what rate light travels through space; how many million vibrations of ether per second are caused by light, and how many vibrations of air by sound; it tells of the chemical components of the Milky Way, of a new element—helium—of micro-organisms and their excrements, of the points on the hand at which electricity collects, of X rays, and similar things.
“But I don't want any of those things,” says a plain and reasonable man—“I want to know how to live.”

Apprehension, uncertainty, waiting, expectation, fear of surprise, do a patient more harm than any exertion. Remember he is face to face with his enemy all the time.

Do the day’s work. If it be to protect the rights of the weak, whoever objects, do it. If it be to help a powerful corporation better to serve the people, whatever the opposition, do that. Expect to be called a stand-patter, but don’t be a stand-patter. Expect to be called a demagogue, but don’t be a demagogue. Don’t hesitate to be as revolutionary as science. Don’t hesitate to be as reactionary as the multiplication table. Don’t expect to build up the weak by pulling down the strong. Don’t hurry to legislate. Give administration a chance to catch up with legislation.

His genius now began to mount upwards apace & shine out with more strength, & as he told me himself, he excelled particularly in making verses... In everything he undertook he discovered an application equal to the pregnancy of his parts & exceeded the most sanguine expectations his master had conceived of him.
[About Newton's recollection of being a schoolboy at Grantham, written by Conduitt about 65 years after that time.]

I fully expect that NASA will send me back to the Moon as they treated Senator [John] Glenn, and if they don't do otherwise, why, then I'll have to do it myself.
About looking forward to the day he turned 77.

I think the next [21st] century will be the century of complexity. We have already discovered the basic laws that govern matter and understand all the normal situations. We don’t know how the laws fit together, and what happens under extreme conditions. But I expect we will find a complete unified theory sometime this century. The is no limit to the complexity that we can build using those basic laws.
[Answer to question: Some say that while the twentieth century was the century of physics, we are now entering the century of biology. What do you think of this?]

If we betake ourselves to the statistical method, we do so confessing that we are unable to follow the details of each individual case, and expecting that the effects of widespread causes, though very different in each individual, will produce an average result on the whole nation, from a study of which we may estimate the character and propensities of an imaginary being called the Mean Man.

It may be said “In research, if you know what you are doing, then you shouldn't be doing it.” In a sense, if the answer turns out to be exactly what you expected, then you have learned nothing new, although you may have had your confidence increased somewhat.

My expectations were reduced to zero when I was 21. Everything since then has been a bonus.

Our children will enjoy in their homes electrical energy too cheap to meter. ... Transmutation of the elements, unlimited power, ability to investigate the working of living cells by tracer atoms, the secret of photosynthesis about to be uncovered, these and a host of other results, all in about fifteen short years. It is not too much to expect that our children will know of great periodic famines in the world only as matters of history, will travel effortlessly over the seas and under the and through the air with a minimum of danger and at great speeds, and will experience a life span far longer than ours, as disease yields and man comes to understand what causes him to age.

Putting on the spectacles of science in expectation of finding an answer to everything looked at signifies inner blindness.

Science itself is badly in need of integration and unification. The tendency is more and more the other way ... Only the graduate student, poor beast of burden that he is, can be expected to know a little of each. As the number of physicists increases, each specialty becomes more self-sustaining and self-contained. Such Balkanization carries physics, and indeed, every science further away, from natural philosophy, which, intellectually, is the meaning and goal of science.

The best class of scientific mind is the same as the best class of business mind. The great desideratum in either case is to know how much evidence is enough to warrant action. It is as unbusiness-like to want too much evidence before buying or selling as to be content with too little. The same kind of qualities are wanted in either case. The difference is that if the business man makes a mistake, he commonly has to suffer for it, whereas it is rarely that scientific blundering, so long as it is confined to theory, entails loss on the blunderer. On the contrary it very often brings him fame, money and a pension. Hence the business man, if he is a good one, will take greater care not to overdo or underdo things than the scientific man can reasonably be expected to take.

The discrepancy between what was expected and what has been observed has grown over the years, and we're straining harder and harder to fill the gap.
[Commenting on the 1984 article in Nature discrediting neutrinos as the explanation for the missing mass of the universe, leaving astrophysicists more baffled for a solution.]

The energy of a covalent bond is largely the energy of resonance of two electrons between two atoms. The examination of the form of the resonance integral shows that the resonance energy increases in magnitude with increase in the overlapping of the two atomic orbitals involved in the formation of the bond, the word ‘overlapping” signifying the extent to which regions in space in which the two orbital wave functions have large values coincide... Consequently it is expected that of two orbitals in an atom the one which can overlap more with an orbital of another atom will form the stronger bond with that atom, and, moreover, the bond formed by a given orbital will tend to lie in that direction in which the orbital is concentrated.

The functional validity of a working hypothesis is not a priori certain, because often it is initially based on intuition. However, logical deductions from such a hypothesis provide expectations (so-called prognoses) as to the circumstances under which certain phenomena will appear in nature. Such a postulate or working hypothesis can then be substantiated by additional observations ... The author calls such expectations and additional observations the prognosis-diagnosis method of research. Prognosis in science may be termed the prediction of the future finding of corroborative evidence of certain features or phenomena (diagnostic facts). This method of scientific research builds up and extends the relations between the subject and the object by means of a circuit of inductions and deductions.

The history of science teaches only too plainly the lesson that no single method is absolutely to be relied upon, that sources of error lurk where they are least expected, and that they may escape the notice of the most experienced and conscientious worker.

Those of us who were familiar with the state of inorganic chemistry in universities twenty to thirty years ago will recall that at that time it was widely regarded as a dull and uninteresting part of the undergraduate course. Usually, it was taught almost entirely in the early years of the course and then chiefly as a collection of largely unconnected facts. On the whole, students concluded that, apart from some relationships dependent upon the Periodic table, there was no system in inorganic chemistry comparable with that to be found in organic chemistry, and none of the rigour and logic which characterised physical chemistry. It was widely believed that the opportunities for research in inorganic chemistry were few, and that in any case the problems were dull and uninspiring; as a result, relatively few people specialized in the subject... So long as inorganic chemistry is regarded as, in years gone by, as consisting simply of the preparations and analysis of elements and compounds, its lack of appeal is only to be expected. The stage is now past and for the purpose of our discussion we shall define inorganic chemistry today as the integrated study of the formation, composition, structure and reactions of the chemical elements and compounds, excepting most of those of carbon.

Unless you expect the unexpected you will never find it, for it is hard to discover and hard to attain.

Where there is an observatory and a telescope, we expect that any eyes will see new worlds at once.