...while science gives us implements to use, science alone does not determine for what ends they will be employed. Radio is an amazing invention. Yet now that it is here, one suspects that Hitler never could have consolidated his totalitarian control over Germany without its use. One never can tell what hands will reach out to lay hold on scientific gifts, or to what employment they will be put. Ever the old barbarian emerges, destructively using the new civilization.

CALPURNIA: When beggars die there are no comets seen;
The heavens themselves blaze forth the death of princes.
CAESAR: Cowards die many times before their deaths;
The valiant never taste of death but once.
Of all the wonders that I have yet heard,
It seems to me most strange that men should fear,
Seeing that death, a necessary end,
Will come when it will come.

All geologic history is full of the beginning and the ends of species–of their first and last days; but it exhibits no genealogies of development.

An example of such emergent phenomena is the origin of life from non-living chemical compounds in the oldest, lifeless oceans of the earth. Here, aided by the radiation energy received from the sun, countless chemical materials were synthesized and accumulated in such a way that they constituted, as it were, a primeval “soup.” In this primeval soup, by infinite variations of lifeless growth and decay of substances during some billions of years, the way of life was ultimately reached, with its metabolism characterized by selective assimilation and dissimilation as end stations of a sluiced and canalized flow of free chemical energy.

And do you know what 'the world' is to me? Shall I,show it to you in my mirror? This world: a monster of energy, without beginning, without end; a firm, iron magnitude of force that does not grow bigger or smaller, that does not expend itself but only transforms itself; as a whole, of unalterable size, a household without expenses or losses, but likewise without increase or income; enclosed by 'nothingness' as by a boundary; not by something blurry or wasted, not something endlessly extended, but set in a definite space as a definite force, and not a space that might be 'empty' here or there, but rather as force throughout, as a play of forces and waves of forces, at the same time one and many, increasing here and at the same time decreasing there; a sea of forces flowing and rushing together, eternally changing, eternally flooding back, with tremendous years of recurrence, with an ebb and a flood of its forms; out of the simplest forms striving toward the most complex, out of the stillest, most rigid, coldest forms toward the hottest, most turbulent, most self-contradictory, and then again returning home to the simple out of this abundance, out of the play of contradictions back to the joy of concord, still affirming itself in this uniformity of its courses and its years, blessing itself as that which must return eternally, as a becoming that knows no satiety, no disgust, no weariness: this, my Dionysian world of the eternally self-creating, the eternally self-destroying, this mystery world of the twofold voluptuous delight, my 'beyond good and evil,' without goal, unless the joy of the circle itself is a goal; without will, unless a ring feels good will toward itself-do you want a name for this world? A solution for all its riddles? A light for you, too, you best-concealed, strongest, most intrepid, most midnightly men?—This world is the will to power—and nothing besides! And you yourselves are also this will to power—and nothing besides!

Both Religion and science require faith in God. For believers, God is in the beginning, and for physicists He is at the end of all considerations.

Eternity is a terrible thought. I mean, where's it going to end?

Every human activity, good or bad, except mathematics, must come to an end.

First follow Nature, and your judgment frame
By her just standard, which is still the same:
Unerring nature, still divinely bright,
One clear, unchanged, and universal light,
Life, force, and beauty must to all impart,
At once the source, and end, and test of art.

For what are the whales being killed? For a few hundred jobs and products that are not needed, since there are cheap substitutes. If this continues, it will be the end of living and the beginning of survival. The world is being totaled.

Heat energy of uniform temperature [is] the ultimate fate of all energy. The power of sunlight and coal, electric power, water power, winds and tides do the work of the world, and in the end all unite to hasten the merry molecular dance.

I do not believe that science per se is an adequate source of happiness, nor do I think that my own scientific outlook has contributed very greatly to my own happiness, which I attribute to defecating twice a day with unfailing regularity. Science in itself appears to me neutral, that is to say, it increases men's power whether for good or for evil. An appreciation of the ends of life is something which must be superadded to science if it is to bring happiness, but only the kind of society to which science is apt to give rise. I am afraid you may be disappointed that I am not more of an apostle of science, but as I grow older, and no doubt—as a result of the decay of my tissues, I begin to see the good life more and more as a matter of balance and to dread all over-emphasis upon anyone ingredient.

I don't dawdle. I'm a surgeon. I make an incision, do what needs to be done and sew up the wound. There is a beginning, a middle, and an end.
[On writing.]

I have said that the investigation for which the teeth of the shark had furnished an opportunity, was very near an end... But thereafter, while I was examining more carefully these details of both places and bodies [sedimentary deposits and shells], these day by day presented points of doubt to me as they followed one another in indissoluble connection, so that I saw myself again and again brought back to the starting-place, as it were, when I thought I was nearest the goal. I might compare those doubts to the heads of the Lernean Hydra, since when one of them had been got rid of, numberless others were born; at any rate, I saw that I was wandering about in a sort of labyrinth, where the nearer one approaches the exit, the wider circuits does one tread.

If there’s more than one way to do a job and one of those ways will end in disaster, then somebody will do it that way.
[Early statement of what became known as Murphy's Law.]

In all matters of opinion and science ... the difference between men is ... oftener found to lie in generals than in particulars; and to be less in reality than in appearance. An explication of the terms commonly ends the controversy, and the disputants are surprised to find that they had been quarrelling, while at bottom they agreed in their judgement.

In the 1920s, there was a dinner at which the physicist Robert W. Wood was asked to respond to a toast ... "To physics and metaphysics." Now by metaphysics was meant something like philosophy—truths that you could get to just by thinking about them. Wood took a second, glanced about him, and answered along these lines: The physicist has an idea, he said. The more he thinks it through, the more sense it makes to him. He goes to the scientific literature, and the more he reads, the more promising the idea seems. Thus prepared, he devises an experiment to test the idea. The experiment is painstaking. Many possibilities are eliminated or taken into account; the accuracy of the measurement is refined. At the end of all this work, the experiment is completed and ... the idea is shown to be worthless. The physicist then discards the idea, frees his mind (as I was saying a moment ago) from the clutter of error, and moves on to something else. The difference between physics and metaphysics, Wood concluded, is that the metaphysicist has no laboratory.

It is clear that there is some difference between ends: some ends are energeia [energy], while others are products which are additional to the energeia.
[The first description of the concept of energy.]

It is good to have an end to journey towards, but it is the journey that matters, in the end.

It is very difficult to say nowadays where the suburbs of London come to an end and where the country begins. The railways, instead of enabling Londoners to live in the country have turned the countryside into a city.

Man has risen, not fallen. He can choose to develop his capacities as the highest animal and to try to rise still farther, or he can choose otherwise. The choice is his responsibility, and his alone. There is no automatism that will carry him upward without choice or effort and there is no trend solely in the right direction. Evolution has no purpose; man must supply this for himself. The means to gaining right ends involve both organic evolution and human evolution, but human choice as to what are the right ends must be based on human evolution.

New ideas seem like frightening ghosts to people at the beginning; they run away from them for a long time, but they get tired of it in the end!

Nothing that you do in science is guaranteed to result in benefits for mankind. Any discovery, I believe, is morally neutral and it can be turned either to constructive ends or destructive ends. That’s not the fault of science.

People of the same trade seldom meet together, even for merriment and diversion, but the conversation ends in a conspiracy against the public, or in some contrivance to raise prices. It is impossible indeed to prevent such meetings, by any law which either could be executed, or would be consistent with liberty and justice.

Piecemeal social engineering resembles physical engineering in regarding the ends as beyond the province of technology. (All that technology may say about ends is whether or not they are compatible with each other or realizable.)

Science, by itself, cannot supply us with an ethic. It can show us how to achieve a given end, and it may show us that some ends cannot be achieved. But among ends that can be achieved our choice must be decided by other than purely scientific considerations. If a man were to say, 'I hate the human race, and I think it would be a good thing if it were exterminated,' we could say, 'Well, my dear sir, let us begin the process with you.' But this is hardly argument, and no amount of science could prove such a man mistaken.

The advance of science is not comparable to the changes of a city, where old edifices are pitilessly torn down to give place to new, but to the continuous evolution of zoologic types which develop ceaselessly and end by becoming unrecognisable to the common sight, but where an expert eye finds always traces of the prior work of the centuries past. One must not think then that the old-fashioned theories have been sterile and vain.

The astronomers said, ‘Give us matter and a little motion and we will construct the universe. It is not enough that we should have matter, we must also have a single impulse, one shove to launch the mass and generate the harmony of the centrifugal and centripetal forces.’ ... There is no end to the consequences of the act. That famous aboriginal push propagates itself through all the balls of the system, and through every atom of every ball.

The fact remains that, if the supply of energy failed, modern civilization would come to an end as abruptly as does the music of an organ deprived of wind.

The framing of hypotheses is, for the enquirer after truth, not the end, but the beginning of his work. Each of his systems is invented, not that he may admire it and follow it into all its consistent consequences, but that he may make it the occasion of a course of active experiment and observation. And if the results of this process contradict his fundamental assumptions, however ingenious, however symmetrical, however elegant his system may be, he rejects it without hesitation. He allows no natural yearning for the offspring of his own mind to draw him aside from the higher duty of loyalty to his sovereign, Truth, to her he not only gives his affections and his wishes, but strenuous labour and scrupulous minuteness of attention.

The life of a wild animal always has a tragic end.

The literature of science is filled with answers found when the question propounded had an entirely different direction and end.

There cannot be design without a designer; contrivance without a contriver; order without choice; arrangement, without any thing capable of arranging; subserviency and relation to a purpose; means suitable to an end, and executing their office in accomplishing that end, without the end ever having been contemplated, or the means accommodated to it. Arrangement, disposition of parts, subserviency of means to an end, relation of instruments to use, imply the preference of intelligence and mind.

There is a tradition of opposition between adherents of induction and of deduction. In my view it would be just as sensible for the two ends of a worm to quarrel.

We are living now, not in the delicious intoxication induced by the early successes of science, but in a rather grisly morning-after, when it has become apparent that what triumphant science has done hitherto is to improve the means for achieving unimproved or actually deteriorated ends.

We have the satisfaction to find, that in nature there is wisdom, system and consistency. For having, in the natural history of this earth, seen a succession of worlds, we may from this conclude that, there is a system in nature; in like manner as, from seeing revolutions of the planets, it is concluded, that there is a system by which they are intended to continue those revolutions. But if the succession of worlds is established in the system of nature, it is vain to look for anything higher in the origin of the earth. The result, therefore, of our present enquiry is, that we find no vestige of a beginning,-no prospect of an end.

Where the telescope ends, the microscope begins. Which of the two has the grander view?

Without the suitable conditions life could not exist. But both life and its conditions set forth the operations of inscrutable Power. We know not its origin; we know not its end. And the presumption, if not the degradation, rests with those who place upon the throne of the universe a magnified image of themselves, and make its doings a mere colossal imitation of their own.

[About any invention] (1) everything that’s already in the world when you’re born is just normal; (2) anything that gets invented between then and before you turn thirty is incredibly exciting and creative and with any luck you can make a career out of it; (3) anything that gets invented after you’re thirty is against the natural order of things and the beginning of the end of civilisation as we know it until it’s been around for about ten years when it gradually turns out to be alright really.

[To] mechanical progress there is apparently no end: for as in the past so in the future, each step in any direction will remove limits and bring in past barriers which have till then blocked the way in other directions; and so what for the time may appear to be a visible or practical limit will turn out to be but a bend in the road.