'Men die of the diseases which they have studied most,' remarked the surgeon, snipping off the end of a cigar with all his professional neatness and finish. 'It's as if the morbid condition was an evil creature which, when it found itself closely hunted, flew at the throat of its pursuer. If you worry the microbes too much they may worry you. I've seen cases of it, and not necessarily in microbic diseases either. There was, of course, the well-known instance of Liston and the aneurism; and a dozen others that I could mention.'

... [I]nfectious disease is merely a disagreeable instance of a widely prevalent tendency of all living creatures to save themselves the bother of building, by their own efforts, the things they require. Whenever they find it possible to take advantage of the constructive labors of others, this is the path of least resistance. The plant does the work with its roots and its green leaves. The cow eats the plant. Man eats both of them; and bacteria (or investment bankers) eat the man. ...

...those who sit at their work and are therefore called 'chair workers,' such as cobblers and tailors, suffer from their own particular diseases ... [T]hese workers ... suffer from general ill-health and an excessive accumulation of unwholesome humors caused by their sedentary life ... so to some extent counteract the harm done by many days of sedentary life.
On the association between chronic inactivity and poor health. Ramazzini urged that workers should at least exercise on holidays

Atten. Pray of what disease did Mr. Badman die, for now I perceive we are come up to his death? Wise. I cannot so properly say that he died of one disease, for there were many that had consented, and laid their heads together to bring him to his end. He was dropsical, he was consumptive, he was surfeited, was gouty, and, as some say, he had a tang of the pox in his bowels. Yet the captain of all these men of death that came against him to take him away, was the consumption, for it was that that brought him down to the grave.

Syphilis sive morbus Gallicus
Syphilis or the French disease.

A man is a poor physician who has not two or three remedies ready for use in every case of illness.

A physician's subject of study is necessarily the patient, and his first field for observation is the hospital. But if clinical observation teaches him to know the form and course of diseases, it cannot suffice to make him understand their nature; to this end he must penetrate into the body to find which of the internal parts are injured in their functions. That is why dissection of cadavers and microscopic study of diseases were soon added to clinical observation. But to-day these various methods no longer suffice; we must push investigation further and, in analyzing the elementary phenomena of organic bodies, must compare normal with abnormal states. We showed elsewhere how incapable is anatomy alone to take account of vital phenenoma, and we saw that we must add study of all physico-chemical conditions which contribute necessary elements to normal or pathological manifestations of life. This simple suggestion already makes us feel that the laboratory of a physiologist-physician must be the most complicated of all laboratories, because he has to experiment with phenomena of life which are the most complex of all natural phenomena.

A study of Disease—of Pestilences methodically prepared and deliberately launched upon man and beast—is certainly being pursue in the laboratories of more than one great country. Blight to destroy crops, Anthrax to slay horses and cattle, Plague to poison not armies but whole districts—such are the lines along which military science is remorselessly advancing.

A substance that makes you ill if you don't eat it.
[His definition of a vitamin.]

All sedentary workers ... suffer from the itch, are a bad colour, and in poor condition ... for when the body is not kept moving the blood becomes tainted, its waste matter lodges in the skin, and the condition of the whole body deteriorates. (1700)

And let me adde, that he that throughly understands the nature of Ferments and Fermentations, shall probably be much better able than he that Ignores them, to give a fair account of divers phenomena of severall diseases (as well Feavers and others) which will perhaps be never throughly understood, without an insight into the doctrine of Fermentation.

Any man who is intelligent must, on considering that health is of the utmost value to human beings, have the personal understanding necessary to help himself in diseases, and be able to understand and to judge what physicians say and what they administer to his body, being versed in each of these matters to a degree reasonable for a layman.

As soon as he ceased to be mad he became merely stupid. There are maladies we must not seek to cure because they alone protect us from others that are more serious.

As to diseases, make a habit of two things—to help, or at least to do no harm.

Asthma is a disease that has practically the same symptoms as passion except that with asthma it lasts longer.

Before thirty, men seek disease; after thirty, diseases seek men.

But nothing is more estimable than a physician who, having studied nature from his youth, knows the properties of the human body, the diseases which assail it, the remedies which will benefit it, exercises his art with caution, and pays equal attention to the rich and the poor.

By the year 2000 the commonest killers such as coronary heart disease, stroke, respiratory, diseases and many cancers will be wiped out.

Certainly it is by their signs and symptoms, that internal diseases are revealed to the physician.

Choose your specialist and you choose your disease.

Conscientious and careful physicians allocate causes of disease to natural laws, while the ablest scientists go back to medicine for their first principles.

Coughs and sneezes spread diseases.

Cure the disease and kill the patient.

Disease is an abnormal state of the body which primarily and independently produces a disturbance in the normal functions of the body. It may be an abnormality of temperament or form (structure). Symptom is a manifestation of some abnormal state in the body. It may be harmful as a colic pain or harmless as the flushing of cheeks in peripneumonia.

Disease is not something personal and special, but only a manifestation of life under modified conditions, operating according to the same laws as apply to the living body at all times, from the first moment until death.

Disease is somatic; the suffering from it, psychic.

Disease makes men more physical, it leaves them nothing but body.

Diseases can rarely be eliminated through early diagnosis or good treatment, but prevention can eliminate disease.

Dissections daily convince us of our ignorance of disease, and cause us to blush at our prescriptions. What mischief have we done under the belief of false facts and false theories! We have assisted in multiplying diseases; we have done more; we have increased their mortality. ... I am pursuing Truth, and am indifferent whither I am led, if she is my only leader.

Doctors are men who prescribe medicines of which they know little, to cure diseases of which they know less, in human beings of whom they know nothing. (1760)

EMOTION, n. A prostrating disease caused by a determination of the heart to the head. It is sometimes accompanied by a copious discharge of hydrated chloride of sodium from the eyes.

Eradication of microbial disease is a will-o'-the-wisp; pursuing it leads into a morass of hazy biological concepts and half truths.

Ever so often in the history of human endeavour, there comes a breakthrough that takes humankind across a frontier into a new era. ... today's announcement is such a breakthrough, a breakthrough that opens the way for massive advancement in the treatment of cancer and hereditary diseases. And that is only the beginning.

Experience, the only logic sure to convince a diseased imagination and restore it to rugged health.

From my numerous observations, I conclude that these tubercle bacilli occur in all tuberculous disorders, and that they are distinguishable from all other microorganisms.

Gluttony is the source of all our infirmities, and the fountain of all our diseases. As a lamp is choked by a superabundance of oil, a fire extinguished by excess of fuel, so is the natural health of the body destroyed by intemperate diet.

Half of the secret of resistance to disease is cleanliness; the other half is dirtiness.

How is it, one fine morning, Duchenne discovered a disease which probably existed in the time of Hippocrates.

How many famous men be there in this our age, which make scruple to condemne these old witches, thinking it to bee nothing but a melancholike humour which corrupteth thei imagination, and filleth them with all these vaines toyes. I will not cast my selfe any further into the depth of this question, the matter craveth a man of more leisure.
Describing melancholy as the innocent affliction of those regarded as witches instead of Satanic influence, while distancing himself from the controversy.

Hypochondria is the only disease I haven't got.

Hypochondriacs squander large sums of time in search of nostrums by which they vainly hope they may get more time to squander.

I am about to discuss the disease called 'sacred'. It is not, in my opinion, any more divine or more sacred that other diseases, but has a natural cause, and its supposed divine origin is due to men's inexperience, and to their wonder at its peculiar character.

I am sorry the infernal Divinities, who visit mankind with diseases, and are therefore at perpetual war with Doctors, should have prevented my seeing all you great Men at Soho to-day-Lord! what inventions, what wit, what rhetoric, metaphysical, mechanical and pyrotecnical, will be on the wing, bandy'd like a shuttlecock from one to another of your troop of philosophers! while poor I, I by myself I, imprizon'd in a post chaise, am joggled, and jostled, and bump'd, and bruised along the King's high road, to make war upon a pox or a fever!

I boast nothing, but plainely say, we all labour against our owne cure, for death is the cure of all diseases.

I here present the reader with a new sign which I have discovered for detecting diseases of the chest. This consists in percussion of the human thorax, whereby, according to the character of the particular sounds then elicited, an opinion is formed of the internal state of that cavity.

I much condole with you on your late loss... pains and diseases of the mind are only cured by Forgetfulness;-—Reason but skins the wound, which is perpetually liable to fester again.

If a lot of cures are suggested for a disease, it means that the disease is incurable.

If diphtheria is a disease caused by a microorganism, it is essential that three postulates be fulfilled. The fulfilment of these postulates is necessary in order to demonstrate strictly the parasitic nature of a disease:
1) The organism must be shown to be constantly present in characteristic form and arrangement in the diseased tissue.
2) The organism which, from its behaviour appears to be responsible for the disease, must be isolated and grown in pure culture.
3) The pure culture must be shown to induce the disease experimentally.
An early statement of Koch's postulates.

If people are constantly falling off a cliff, you could place ambulances under the cliff or build a fence on the top of the cliff. We are placing all too many ambulances under the cliff.

If you are physically sick, you can elicit the interest of a battery of physicians; but if you are mentally sick, you are lucky if the janitor comes around.

In acute diseases the physician must conduct his inquiries in the following way. First he must examine the face of the patient, and see whether it is like the faces of healthy people, and especially whether it is like its usual self. Such likeness will be the best sign, and the greatest unlikeness will be the most dangerous sign. The latter will be as follows. Nose sharp, eyes hollow, temples sunken, ears cold and contracted with their lobes turned outwards, the skin about the face hard and tense and parched, the colour of the face as a whole being yellow or black.

In my experience of anorexia nervosa it is exclusively a disease of private patients.

In the first papers concerning the aetiology of tuberculosis I have already indicated the dangers arising from the spread of the bacilli-containing excretions of consumptives, and have urged moreover that prophylactic measures should be taken against the contagious disease. But my words have been unheeded. It was still too early, and because of this they still could not meet with full understanding. It shared the fate of so many similar cases in medicine, where a long time has also been necessary before old prejudices were overcome and the new facts were acknowledged to be correct by the physicians.

In the first papers concerning the aetiology of tuberculosis I have already indicated the dangers arising from the spread of the bacilli-containing excretions of consumptives, and have urged moreover that prophylactic measures should be taken against the contagious disease. But my words have been unheeded. It was still too early, and because of this they still could not meet with full understanding. It shared the fate of so many similar cases in medicine, where a long time has also been necessary before old prejudices were overcome and the new facts were acknowledged to be correct by the physicians.

In the midst of your illness you will promise a goat, but when you have recovered, a chicken will seem sufficient.

In the nineteenth century men lost their fear of God and acquired a fear of microbes.

In typhoid treat the beginning; in consumption do not treat the end.

Infectious disease is one of the few genuine adventures left in the world. The dragons are all dead and the lance grows rusty in the chimney corner. ... About the only sporting proposition that remains unimpaired by the relentless domestication of a once free-living human species is the war against those ferocious little fellow creatures, which lurk in dark corners and stalk us in the bodies of rats, mice and all kinds of domestic animals; which fly and crawl with the insects, and waylay us in our food and drink and even in our love

Insomnia: A contagious disease often transmitted from babies to parents.

Is not disease the rule of existence? There is not a lily pad floating on the river but has been riddled by insects. Almost every shrub and tree has its gall, oftentimes esteemed its chief ornament and hardly to be distinguished from the fruit. If misery loves company, misery has company enough. Now, at midsummer, find me a perfect leaf or fruit.

It is important to go into work you would like to do. Then it doesn't seem like work. You sometimes feel it's almost too good to be true that someone will pay you for enjoying yourself. I've been very fortunate that my work led to useful drugs for a variety of serious illnesses. The thrill of seeing people get well who might otherwise have died of diseases like leukemia, kidney failure, and herpes virus encephalitis cannot be described in words.

It is in moments of illness that we are compelled to recognize that we live not alone but chained to a creature of a different kingdom, whole worlds apart, who has no knowledge of us, and by whom it is impossible to make ourselves understood: our body.

It is not what disease the patient has but which patient has the disease.

Let out the blood, let out the disease.

Lice, ticks, mosquitoes and bedbugs will always lurk in the shadows when neglect, poverty, famine or war lets down the defenses.

Many Diseases arise from a perverted Imagination; and some of them are cured by affecting the Imagination only.

Medical science has proven time and again that when the resources are provided, great progress in the treatment, cure and prevention of disease can occur.

My crystal ball or intuition tells me that in the '80s the impact of RIA [radioimmunoassay] on the study of infectious diseases may prove as revolutionary as its impact on endocrinology in the 60s.

My friend was sick: I attended him.
He died; I dissected him.

Nature being capricious and taking pleasure in creating and producing a continuous sucession of lives and forms because she knows that they serve to increase her terrestrial substance, is more ready and swift in her creating than time is in destroying, and therefore she has ordained that many animals shall serve as food one for the other; and as this does not satisfy her desire she sends forth frequently certain noisome and pestilential vapours and continual plagues upon the vast accumulations and herds of animals and especially upon human beings who increase very rapidly because other animals do not feed upon them.

Nature is nowhere accustomed more openly to display her secret mysteries than in cases where she shows tracings of her workings apart from the beaten paths; nor is there any better way to advance the proper practice of medicine than to give our minds to the discovery of the usual law of nature, by careful investigation of cases of rarer forms of disease.

Nature, in the first compoundiug and forming of us, hath laid into the Substance and Constitution of each something equivalent to Ovula, of various distinct Kinds, productive of all the contagious, venomous Fevers, we can possibly have as long as we live.

Neurosis has an abosolute genius for malingering. There is no illness which cannot counterfeit perfectly … If it is capable of deceiving the doctor, how should it fail to deceive the patient.

No man is a good doctor who has never been sick himself.

Often the confidence of the patient in his physician does more for the cure of his disease than the physician with all his remedies.
Reasserting the statement by Avicenna.

One of the major goals when studying specific genetic diseases is to find the primary gene product, which in turn leads to a better understanding of the biochemical basis of the disorder. The bottom line often reads, 'This may lead to effective prenatal diagnosis and eventual eradication of the disease.' But we now have the ironic situation of being able to jump right to the bottom line without reading the rest of the page, that is, without needing to identify the primary gene product or the basic biochemical mechanism of the disease. The technical capability of doing this is now available. Since the degree of departure from our previous approaches and the potential of this procedure are so great, one will not be guilty of hyperbole in calling it the 'New Genetics'.

Opium is the only drug to' be rely'd on—all the boasted nostrums only take up time, and as the disease [is] often of short duration, or of small quantity, they have gain'd credit which they do not deserve.

People ask me often [whether] the Nobel Prize [was] the thing you were aiming for all your life, and I say that would be crazy. Nobody would aim for a Nobel Prize because, if you didn't get it, your whole life would be wasted. What we were aiming at was getting people well, and the satisfaction of that is much greater than any prize you can get.

People don't die from the old diseases any more. They die from new ones, but that's Progress, isn’t it?
Isn't it?

Physicians of the Utmost Fame
Were called at once; but when they came
They answered, as they took their Fees,
'There is no Cure for this Disease.'

Rheumatic fever licks at the joints, but bites at the heart.

Somewhere between 1900 and 1912 in this country, according to one sober medical scientist [Henderson] a random patient, with a random disease, consulting a doctor chosen at random had, for the first time in the history of mankind, a better than fifty-fifty chance of profiting from the encounter.

Statistics has been the handmaid of science, and has poured a flood of light upon the dark questions of famine and pestilence, ignorance and crime, disease and death.

That was the turning point. It was as though the signal was there, 'This is the disease you're going to have to work against.' I never really stopped to think about anything else. It was that sudden.

The appearance of a disease is swift as an arrow; its disappearance slow, like a thread.

The art of medicine consists of amusing the patient while nature cures the disease.

The fact is that in creating towns, men create the materials for an immense hotbed of disease, and this effect can only be neutralised by extraordinary artificial precautions.

The facts obtained in this study may possibly be sufficient proof of the causal relationship, that only the most sceptical can raise the objection that the discovered microorganism is not the cause but only an accompaniment of the disease... It is necessary to obtain a perfect proof to satisfy oneself that the parasite and the disease are ... actually causally related, and that the parasite is the... direct cause of the disease. This can only be done by completely separating the parasite from the diseased organism [and] introducing the isolated parasite into healthy organisms and induce the disease anew with all its characteristic symptoms and properties.

The first Care in building of Cities, is to make them airy and well perflated; infectious Distempers must necessarily be propagated amongst Mankind living close together.

The forms of diseases are many and the healing of them is manifold.

The name chronic alcoholism applies to the collective symptoms of a disordered condition of the mental, motor, and sensory functions of the nervous system, these symptoms assuming a chronic form, and without their being immediately connected with any of those (organic) modifications of the central or peripheric portions of the nervous system which may be detected during life, or discovered after death by ocular inspection; such symptoms, moreover, affecting individuals who have persisted for a considerable length of time in the abuse of alcoholic liquors.

The only English patients I have ever known refuse tea, have been typhus cases; and the first sign of their getting better was their craving again for tea.

The only way we are going to reduce disease, is to go backward to the diets and lifestyles of our ancestors.

The origin and the causes of disease are far too recondite for the human mind to unravel them.

The physician himself, if sick, actually calls in another physician, knowing that he cannot reason correctly if required to judge his own condition while suffering.

The pure culture is the foundation for all research on infectious disease.

The remedy is worse than the disease.

The unlucky doctor treats the head of a disease; the lucky doctor its tail.

There are some arts which to those that possess them are painful, but to those that use them are helpful, a common good to laymen, but to those that practise them grievous. Of such arts there is one which the Greeks call medicine. For the medical man sees terrible sights, touches unpleasant things, and the misfortunes of others bring a harvest of sorrows that are peculiarly his; but the sick by means of the art rid themselves of the worst of evils, disease, suffering, pain and death.

There is at bottom only one genuinely scientific treatment for all diseases, and that is to stimulate the phagocytes.

There is no curing a sick man who believes himself to be in health.

These symptoms are formed in such a particular way that they form a disease group in themselves and thus merit being designated and described as a definite disease ... It is this group of symptoms which I wish to designate by the name Alcoholismus chronicus.

This is a mighty wonder: in the discharge from the lungs alone, which is not particularly dangerous, the patients do not despair of themselves, even although near the last.
Concerning Tuberculosis.

Thou to whom the sick and dying
Ever came, nor came in vain,
With thy healing hands replying
To their wearied cry of pain.

Tis not always in a physician's power to cure the sick; at times the disease is stronger than trained art.

To choose a rough example, think of a thorn which has stuck in a finger and produces an inflammation and suppuration. Should the thorn be discharged with the pus, then the finger of another individual may be pricked with it, and the disease may be produced a second time. In this case it would not be the disease, not even its product, that would be transmitted by the thorn, but rather the stimulus which engendered it. Now supposing that the thorn is capable of multiplying in the sick body, or that every smallest part may again become a thorn, then one would be able to excite the same disease, inflammation and suppuration, in other individuals by transmitting any of its smallest parts. The disease is not the parasite but the thorn. Diseases resemble one another, because their causes resemble each other. The contagion in our sense is therefore not the germ or seed of the disease, but rather the cause of the disease. For example, the egg of a taenia is not the product of a worm disease even though the worm disease may have been the cause, which first gave rise to the taenia in the intestinal contents—nor of the individual afflicted with the worm disease, but rather of the parasitic body, which, no matter how it may have come into the world at first, now reproduces itself by means of eggs, and produces the symptoms of the worm disease, at least in part. It is not the seed of the disease; the latter multiplies in the sick organism, and is again excreted at the end of the disease.

To prove that tuberculosis is caused by the invasion of bacilli, and that it is a parasitic disease primarily caused by the growth and multiplication of bacilli, it is necessary to isolate the bacilli from the body, to grow them in pure culture until they are freed from every disease product of the animal organism, and, by introducing isolated bacilli into animals, to reproduce the same morbid condition that is known to follow from inoculation with spontaneously developed tuberculous material.

TZETZE, (or TSETSE) FLY, n. An African insect (Glossina morsitans) whose bite is commonly regarded as nature's most efficacious remedy for insomnia, though some patients prefer that of the American novelist (Mendax interminabilis.)

We are led to think of diseases as isolated disturbances in a healthy body, not as the phases of certain periods of bodily development.

We have chosen to write the biography of our disease because we love it platonically — as Amy Lowell loved Keats — and have sought its acquaintance wherever we could find it. And in this growing intimacy we have become increasingly impressed with the influence that this and other infectious diseases, which span — in their protoplasmic continuities — the entire history of mankind, have had upon the fates of men.

We should give free passage to diseases; ... Let us give Nature a chance; she knows her business better than we do.

When a disease relapses there is no cure.

When there are too many deer in the forest or too many cats in the barn, nature restores the balance by the introduction of a communicable disease or virus.

Why Become Extinct? Authors with varying competence have suggested that dinosaurs disappeared because the climate deteriorated (became suddenly or slowly too hot or cold or dry or wet), or that the diet did (with too much food or not enough of such substances as fern oil; from poisons in water or plants or ingested minerals; by bankruptcy of calcium or other necessary elements). Other writers have put the blame on disease, parasites, wars, anatomical or metabolic disorders (slipped vertebral discs, malfunction or imbalance of hormone and endocrine systems, dwindling brain and consequent stupidity, heat sterilization, effects of being warm-blooded in the Mesozoic world), racial old age, evolutionary drift into senescent overspecialization, changes in the pressure or composition of the atmosphere, poison gases, volcanic dust, excessive oxygen from plants, meteorites, comets, gene pool drainage by little mammalian egg-eaters, overkill capacity by predators, fluctuation of gravitational constants, development of psychotic suicidal factors, entropy, cosmic radiation, shift of Earth's rotational poles, floods, continental drift, extraction of the moon from the Pacific Basin, draining of swamp and lake environments, sunspots, God's will, mountain building, raids by little green hunters in flying saucers, lack of standing room in Noah's Ark, and palaeoweltschmerz.

[I have seen] workers in whom certain morbid affections gradually arise from some particular posture of the limbs or unnatural movements of the body called for while they work. Such are the workers who all day stand or sit, stoop or are bent double, who run or ride or exercise their bodies in all sorts of [excess] ways. ... the harvest of diseases reaped by certain workers ... [from] irregular motions in unnatural postures of the body.