... we ought to have saints' days to commemorate the great discoveries which have been made for all mankind, and perhaps for all time—or for whatever time may be left to us. Nature ... is a prodigal of pain. I should like to find a day when we can take a holiday, a day of jubilation when we can fête good Saint Anaesthesia and chaste and pure Saint Antiseptic. ... I should be bound to celebrate, among others, Saint Penicillin...

...I believe there exists, & I feel within me, an instinct for the truth, or knowledge or discovery, of something of the same nature as the instinct of virtue, & that our having such an instinct is reason enough for scientific researches without any practical results ever ensuing from them.

...neither is it possible to discover the more remote and deeper parts of any science, if you stand but upon the level of the same science, and ascend not to a higher science.

Deviner avant de démontrer! Ai-je besoin de rappeler que c'est ainsi que se sont faites toutes les découvertes importantes.
Guessing before proving! Need I remind you that it is so that all important discoveries have been made?

Discovery always carries an honorific connotation. It is the stamp of approval on a finding of lasting value. Many laws and theories have come and gone in the history of science, but they are not spoken of as discoveries. Kepler is said to have discovered the laws of planetary motion named after him, but no the many other 'laws' which he formulated. ... Theories are especially precarious, as this century profoundly testifies. World views can and do often change. Despite these difficulties, it is still true that to count as a discovery a finding must be of at least relatively permanent value, as shown by its inclusion in the generally accepted body of scientific knowledge.

Eureka! Eureka!
[I have found it!]
Supposed to have been his cry, jumping naked from his bath and running in the streets, excited by a discovery about water displacement to solve a problem about the purity of a gold crown.

Le seul véritable voyage ... ce ne serait pas d’aller vers de nouveaux paysages, mais d’avoir d’autres yeux, de voir l’univers avec les yeux d’un autre, de cent autres, de voir les cent univers que chacun d’eux voit …
The only true voyage of discovery … would be not to visit new landscapes, but to possess other eyes, to see the universe through the eyes of another, of a hundred others, to see the hundred universes that each of them sees.
[Also often seen translated in the shortened form: 'The only real voyage of discovery consists not in seeing new landscapes, but in having new eyes.']

A drop from the nose of Fleming, who had a cold, fell onto an agar plate where large yellow colonies of a contaminant had grown, and lysosyme was discovered. He made this important discovery because when he saw that the colonies of the contaminant were fading, his mind went straight to the right cause of the phenomenon he was observing—that the drop from his nose contained a lytic substance. And also immediately, he thought that this substance might be present in many secretions and tissues of the body. And he found this was so—the substance was in tears, saliva, leucocytes, skin, fingernails, mother's milk—thus very widely distributed in amounts and also in plants.

A lot of prizes have been awarded for showing the universe is not as simple as we might have thought.

About eight days ago I discovered that sulfur in burning, far from losing weight, on the contrary, gains it; it is the same with phosphorus; this increase of weight arises from a prodigious quantity of air that is fixed during combustion and combines with the vapors. This discovery, which I have established by experiments, that I regard as decisive, has led me to think that what is observed in the combustion of sulfur and phosphorus may well take place in the case of all substances that gain in weight by combustion and calcination; and I am persuaded that the increase in weight of metallic calxes is due to the same cause... This discovery seems to me one of the most interesting that has been made since Stahl and since it is difficult not to disclose something inadvertently in conversation with friends that could lead to the truth I have thought it necessary to make the present deposit to the Secretary of the Academy to await the time I make my experiments public.

All creation is a mine, and every man a miner.
The whole earth, and all within it, upon it, and round about it, including himself … are the infinitely various 'leads' from which, man, from the first, was to dig out his destiny.

All great discoveries are made by men whose feelings run ahead of their thinking.

All human discoveries seem to be made only for the purpose of confirming more strongly the truths come from on high, and contained in the sacred writings.

All the modern higher mathematics is based on a calculus of operations, on laws of thought. All mathematics, from the first, was so in reality; but the evolvers of the modern higher calculus have known that it is so. Therefore elementary teachers who, at the present day, persist in thinking about algebra and arithmetic as dealing with laws of number, and about geometry as dealing with laws of surface and solid content, are doing the best that in them lies to put their pupils on the wrong track for reaching in the future any true understanding of the higher algebras. Algebras deal not with laws of number, but with such laws of the human thinking machinery as have been discovered in the course of investigations on numbers. Plane geometry deals with such laws of thought as were discovered by men intent on finding out how to measure surface; and solid geometry with such additional laws of thought as were discovered when men began to extend geometry into three dimensions.

Anatomists have ever been engaged in contention. And indeed, if a man has not such a degree of enthusiasm, and love of the art, as will make him impatient of unreasonable opposition and of encroachments upon his discoveries and his reputation, he will hardly become considerable in Anatomy or in any branch of natural knowledge.

Another argument of hope may be drawn from this–that some of the inventions already known are such as before they were discovered it could hardly have entered any man's head to think of; they would have been simply set aside as impossible. For in conjecturing what may be men set before them the example of what has been, and divine of the new with an imagination preoccupied and colored by the old; which way of forming opinions is very fallacious, for streams that are drawn from the springheads of nature do not always run in the old channels.

any new fact or insight that I may have found has not seemed to me as a 'discovery' of mine, but rather something that had always been there and that I had chanced to pick up.

Aristotle discovered all the half-truths which were necessary to the creation of science.

At lunch Francis [Crick] winged into the Eagle to tell everyone within hearing distance that we had found the secret of life.

At the moment I am occupied by an investigation with Kirchoff which does not allow us to sleep. Kirchoff has made a totally unexpected discovery, inasmuch as he has found out the cause for the dark lines in the solar spectrum and can produce these lines artificially intensified both in the solar spectrum and in the continuous spectrum of a flame, their position being identical with that of Fraunhofer’s lines. Hence the path is opened for the determination of the chemical composition of the Sun and the fixed stars.

At the moment I am occupied by an investigation with Kirchoff which does not allow us to sleep. Kirchoff has made a totally unexpected discovery, inasmuch as he has found out the cause for the dark lines in the solar spectrum and can produce these lines artificially intensified both in the solar spectrum and in the continuous spectrum of a flame, their position being identical with that of Fraunhofer’s lines. Hence the path is opened for the determination of the chemical composition of the Sun and the fixed stars.

Brutes by their natural instinct have produced many discoveries, whereas men by discussion and the conclusions of reason have given birth to few or none.

But it is just this characteristic of simplicity in the laws of nature hitherto discovered which it would be fallacious to generalize, for it is obvious that simplicity has been a part cause of their discovery, and can, therefore, give no ground for the supposition that other undiscovered laws are equally simple

But medicine has long had all its means to hand, and has discovered both a principle and a method, through which the discoveries made during a long period are many and excellent, while full discovery will be made, if the inquirer be competent, conduct his researches with knowledge of the discoveries already made, and make them his starting-point. But anyone who, casting aside and rejecting all these means, attempts to conduct research in any other way or after another fashion, and asserts that he has found out anything, is and has been victim of deception.

Deductivism in mathematical literature and inductivism in scientific papers are simply the postures we choose to be seen in when the curtain goes up and the public sees us. The theatrical illusion is shattered if we ask what goes on behind the scenes. In real life discovery and justification are almost always different processes.

Discovery consists of seeing what everybody has seen and thinking what nobody has thought.

Do not expect to be hailed as a hero when you make your great discovery. More likely you will be a ratbag—maybe failed by your examiners. Your statistics, or your observations, or your literature study, or your something else will be patently deficient. Do not doubt that in our enlightened age the really important advances are and will be rejected more often than acclaimed. Nor should we doubt that in our own professional lifetime we too will repudiate with like pontifical finality the most significant insight ever to reach our desk.

During the eighteenth and nineteenth centuries we can see the emergence of a tension that has yet to be resolved, concerning the attitude of scientists towards the usefulness of science. During this time, scientists were careful not to stress too much their relationships with industry or the military. They were seeking autonomy for their activities. On the other hand, to get social support there had to be some perception that the fruits of scientific activity could have useful results. One resolution of this dilemma was to assert that science only contributed at the discovery stage; others, industrialists for example, could apply the results. ... Few noted the ... obvious paradox of this position; that, if scientists were to be distanced from the 'evil' effects of the applications of scientific ideas, so too should they receive no credit for the 'good' or socially beneficial, effects of their activities.
Co-author with Philip Gummett (1947- ), -British social scientist

Engineering or Technology is the making of things that did not previously exist, whereas science is the discovering of things that have long existed.

Equations seem like treasures, spotted in the rough by some discerning individual, plucked and examined, placed in the grand storehouse of knowledge, passed on from generation to generation. This is so convenient a way to present scientific discovery, and so useful for textbooks, that it can be called the treasure-hunt picture of knowledge.

Every discovery opens a new field for investigation of facts, shows us the imperfection of our theories. It has justly been said, that the greater the circle of light, the greater the boundary of darkness by which it is surrounded.

Facts, and facts alone, are the foundation of science... When one devotes oneself to experimental research it is in order to augment the sum of known facts, or to discover their mutual relations.

First... a new theory is attacked as absurd; then it is admitted to be true, but obvious and insignificant; finally it is seen to be so important that its adversaries claim that they themselves discovered it.

For the pre-Darwinian age had come to be regarded as a Dark Age in which men still believed that the book of Genesis was a standard scientific treatise, and that the only additions to it were Galileo'a demonstration of Leonardo da Vinci's simple remark that the earth is a moon of the sun, Sir Humphrey Davy's invention of the safety lamp, the discovery of electricity, the application of steam to industrial purposes, and the penny post.

Foreshadowings of the principles and even of the language of [the infinitesimal] calculus can be found in the writings of Napier, Kepler, Cavalieri, Pascal, Fermat, Wallis, and Barrow. It was Newton's good luck to come at a time when everything was ripe for the discovery, and his ability enabled him to construct almost at once a complete calculus.

Great discoveries are made accidentally less often than the populace likes to think.
Commenting on how an accident led to the discovery of X-rays..

His [Faraday's] third great discovery is the Magnetization of Light, which I should liken to the Weisshorn among mountains-high, beautiful, and alone.

I do not seek, I find.

I do not think that G. H. Hardy was talking nonsense when he insisted that the mathematician was discovering rather than creating, nor was it wholly nonsense for Kepler to exult that he was thinking God's thoughts after him. The world for me is a necessary system, and in the degree to which the thinker can surrender his thought to that system and follow it, he is in a sense participating in that which is timeless or eternal.

I don't believe medical discoveries are doing much to advance human life. As fast as we create ways to extend it we are inventing ways to shorten it.

I doubt that Fleming could have obtained a grant for the discovery of penicillin on that basis [a requirement for highly detailed research plans] because he could not have said, 'I propose to have an accident in a culture so that it will be spoiled by a mould falling on it, and I propose to recognize the possibility of extracting an antibiotic from this mould.'

I had fallen in love with a young man..., and we were planning to get married. And then he died of subacute bacterial endocarditis... Two years later with the advent of penicillin, he would have been saved. It reinforced in my mind the importance of scientific discovery...

I have been speculating last night what makes a man a discoverer of undiscovered things; and a most perplexing problem it is. Many men who are very clever - much cleverer than the discoverers - never originate anything.

I have been trying to point out that in our lives chance may have an astonishing influence and, if I may offer advice to the young laboratory worker, it would be this—never neglect an extraordinary appearance or happening. It may be—usually is, in fact—a false alarm that leads to nothing, but may on the other hand be the clue provided by fate to lead you to some important advance.

I looked for it [heavy hydrogen, deuterium] because I thought it should exist. I didn't know it would have industrial applications or be the basic for the most powerful weapon ever known [the nuclear bomb] ... I thought maybe my discovery might have the practical value of, say, neon in neon signs.
[He was awarded the 1931 Nobel Prize in Chemistry for discovering deuterium.]

I think a strong claim can be made that the process of scientific discovery may be regarded as a form of art. This is best seen in the theoretical aspects of Physical Science. The mathematical theorist builds up on certain assumptions and according to well understood logical rules, step by step, a stately edifice, while his imaginative power brings out clearly the hidden relations between its parts. A well constructed theory is in some respects undoubtedly an artistic production. A fine example is the famous Kinetic Theory of Maxwell. ... The theory of relativity by Einstein, quite apart from any question of its validity, cannot but be regarded as a magnificent work of art.
Responding to the toast, 'Science!' at the Royal Academy of the Arts in 1932.)

I want to stay as close to the edge as I can without going over. Out on the edge you see all kinds of things you can't see from the center.

I was working with a Crookes tube covered by a shield of black cardboard. A piece of barium platino-cyanide paper lay on the bench there. I had been passing a current through the tube, and I noticed a peculiar black line across the paper. ...
The effect was one which could only be produced in ordinary parlance by the passage of light. No light could come from the tube because the shield which covered it was impervious to any light known even that of the electric arc. ...
I did not think I investigated. ...
I assumed that the effect must have come from the tube since its character indicated that it could come from nowhere else. ... It seemed at first a new kind of invisible light. It was clearly something new something unrecorded. ...
There is much to do, and I am busy, very busy.[Describing to a journalist the discovery of X-rays that he had made on 8 Nov 1895.]

If any human being earnestly desire to push on to new discoveries instead of just retaining and using the old; to win victories over Nature as a worker rather than over hostile critics as a disputant; to attain, in fact, clear and demonstrative knowlegde instead of attractive and probable theory; we invite him as a true son of Science to join our ranks.

If others would but reflect on mathematical truths as deeply and continuously as I have, they would make my discoveries.

If Watson and I had not discovered the [DNA] structure, instead of being revealed with a flourish it would have trickled out and that its impact would have been far less. For this sort of reason Stent had argued that a scientific discovery is more akin to a work of art than is generally admitted. Style, he argues, is as important as content. I am not completely convinced by this argument, at least in this case.

If we do discover a complete theory, it should be in time understandable in broad principle by everyone ... Then we shall all, philosophers, scientists and just ordinary people, be able to take part in the discussion of why it is that we and the universe exist. If we find the answer to that, it would be the ultimate triumph of human reason—for then we would know the mind of God.

If we have learned one thing from the history of invention and discovery, it is that, in the long run—and often in the short one—the most daring prophecies seem laughably conservative.

If we make a couple of discoveries here and there we need not believe things will go like this for ever. An acrobat can leap higher than a farm-hand, and one acrobat higher than another, yet the height no man can overleap is still very low. Just as we hit water when we dig in the earth, so we discover the incomprehensible sooner or later.

Imagination is the Discovering Faculty, pre-eminently ... It is that which feels & discovers what is, the REAL which we see not, which exists not for our senses... Mathematical science shows what is. It is the language of unseen relations between things... Imagination too shows what is ... Hence she is or should be especially cultivated by the truly Scientific, those who wish to enter into the worlds around us!

Imagine the people who believe such things and who are not ashamed to ignore, totally, all the patient findings of thinking minds through all the centuries since the Bible was written. And it is these ignorant people, the most uneducated, the most unimaginative, the most unthinking among us, who would make themselves the guides and leaders of us all; who would force their feeble and childish beliefs on us; who would invade our schools and libraries and homes. I personally resent it bitterly.

In my first publication I might have claimed that I had come to the conclusion, as a result of serious study of the literature and deep thought, that valuable antibacterial substances were made by moulds and that I set out to investigate the problem. That would have been untrue and I preferred to tell the truth that penicillin started as a chance observation. My only merit is that I did not neglect the observation and that I pursued the subject as a bacteriologist. My publication in 1929 was the starting-point of the work of others who developed penicillin especially in the chemical field.

In Science, it is when we take some interest in the great discoverers and their lives that it becomes endurable, and only when we begin to trace the development of ideas that it becomes fascinating.

In scientific matters ... the greatest discoverer differs from the most arduous imitator and apprentice only in degree, whereas he differs in kind from someone whom nature has endowed for fine art. But saying this does not disparage those great men to whom the human race owes so much in contrast to those whom nature has endowed for fine art. For the scientists' talent lies in continuing to increase the perfection of our cognitions and on all the dependent benefits, as well as in imparting that same knowledge to others; and in these respects they are far superior to those who merit the honour of being called geniuses. For the latter's art stops at some point, because a boundary is set for it beyond which it cannot go and which has probably long since been reached and cannot be extended further.

In the discovery of hidden things and the investigation of hidden causes, stronger reasons are obtained from sure experiments and demonstrated arguments than from probable conjectures and the opinions of philosophical speculators of the common sort...

In the history of physics, there have been three great revolutions in thought that first seemed absurd yet proved to be true. The first proposed that the earth, instead of being stationary, was moving around at a great and variable speed in a universe that is much bigger than it appears to our immediate perception. That proposal, I believe, was first made by Aristarchos two millenia ago ... Remarkably enough, the name Aristarchos in Greek means best beginning.
[The next two revolutions occurred ... in the early part of the twentieth century: the theory of relativity and the science of quantum mechanics...]

In the world's history certain inventions and discoveries occurred of peculiar value, on account of their great efficiency in facilitating all other inventions and discoveris. Of these were the art of writing and of printing, the discovery of America, and the introduction of patent laws. The date of the first ... is unknown; but it certainly was as much as fifteen hundred years before the Christian era; the second—printing—came in 1436, or nearly three thousand years after the first. The others followed more rapidly—the discovery of America in 1492, and the first patent laws in 1624.

Indeed, nothing more beautifully simplifying has ever happened in the history of science than the whole series of discoveries culminating about 1914 which finally brought practically universal acceptance to the theory that the material world contains but two fundamental entities, namely, positive and negative electrons, exactly alike in charge, but differing widely in mass, the positive electron—now usually called a proton—being 1850 times heavier than the negative, now usually called simply the electron.

It can happen to but few philosophers, and but at distant intervals, to snatch a science, like Dalton, from the chaos of indefinite combination, and binding it in the chains of number, to exalt it to rank amongst the exact. Triumphs like these are necessarily 'few and far between.'

It is a very strange thing to reflect that but for the invention of Professor Haber the Germans could not have continued the War after their original stack of nitrates was exhausted. The invention of this single man has enabled them, utilising the interval in which their accumulations were used up, not only to maintain an almost unlimited supply of explosives for all purposes, but to provide amply for the needs of agriculture in chemical manures. It is a remarkable fact, and shows on what obscure and accidental incidents the fortunes of possible the whole world may turn in these days of scientific discovery.
[During World War I, Fritz Haber and Karl Bosch invented a large scale process to cause the direct combination of hydrogen and nitrogen gases to chemically synthesize ammonia, thus providing a replacement for sodium nitrate in the manufacture of explosives and fertilizers.]

It is by logic that we prove, but by intuition that we discover.

It is characteristic of our age to endeavour to replace virtues by technology. That is to say, wherever possible we strive to use methods of physical or social engineering to achieve goals which our ancestors thought attainable only by the training of character. Thus, we try so far as possible to make contraception take the place of chastity, and anaesthetics to take the place of fortitude; we replace resignation by insurance policies and munificence by the Welfare State. It would be idle romanticism to deny that such techniques and institutions are often less painful and more efficient methods of achieving the goods and preventing the evils which unaided virtue once sought to achieve and avoid. But it would be an equal and opposite folly to hope that the take-over of virtue by technology may one day be complete, so that the necessity for the laborious acquisition of the capacity for rational choice by individuals can be replaced by the painless application of the fruits of scientific discovery over the whole field of human intercourse and enterprise.

It is folly to use as one's guide in the selection of fundamental science the criterion of utility. Not because (scientists)... despise utility. But because. .. useful outcomes are best identified after the making of discoveries, rather than before.
Concerning the allocation of research funds.

It is impossible not to feel stirred at the thought of the emotions of man at certain historic moments of adventure and discovery—Columbus when he first saw the Western shore, Pizarro when he stared at the Pacific Ocean, Franklin when the electric spark came from the string of his kite, Galileo when he first turned his telescope to the heavens. Such moments are also granted to students in the abstract regions of thought, and high among them must be placed the morning when Descartes lay in bed and invented the method of co-ordinate geometry.

It is not enough to discover and prove a useful truth previously unknown, but that it is necessary also to be able to propagate it and get it recognized.

It is not the nature of things for any one man to make a sudden, violent discovery; science goes step by step and every man depends on the work of his predecessors. When you hear of a sudden unexpected discovery - a bolt from the blue - you can always be sure that it has grown up by the influence of one man or another, and it is the mutual influence which makes the enormous possibility of scientific advance. Scientists are not dependent on the ideas of a single man, but on the combined wisdom of thousands of men, all thinking of the same problem and each doing his little bit to add to the great structure of knowledge which is gradually being erected.

It is not therefore the business of philosophy, in our present situation in the universe, to attempt to take in at once, in one view, the whole scheme of nature; but to extend, with great care and circumspection, our knowledge, by just steps, from sensible things, as far as our observations or reasonings from them will carry us, in our enquiries concerning either the greater motions and operations of nature, or her more subtile and hidden works. In this way Sir Isaac Newton proceeded in his discoveries.

It is not, indeed, strange that the Greeks and Romans should not have carried ... any ... experimental science, so far as it has been carried in our time; for the experimental sciences are generally in a state of progression. They were better understood in the seventeenth century than in the sixteenth, and in the eighteenth century than in the seventeenth. But this constant improvement, this natural growth of knowledge, will not altogether account for the immense superiority of the modern writers. The difference is a difference not in degree, but of kind. It is not merely that new principles have been discovered, but that new faculties seem to be exerted. It is not that at one time the human intellect should have made but small progress, and at another time have advanced far; but that at one time it should have been stationary, and at another time constantly proceeding. In taste and imagination, in the graces of style, in the arts of persuasion, in the magnificence of public works, the ancients were at least our equals. They reasoned as justly as ourselves on subjects which required pure demonstration.

It is notorious that the same discovery is frequently made simultaneously and quite independently, by different persons. Thus, to speak of only a few cases in late years, the discoveries of photography, of electric telegraphy, and of the planet Neptune through theoretical calculations, have all their rival claimants. It would seem, that discoveries are usually made when the time is ripe for them—that is to say, when the ideas from which they naturally flow are fermenting in the minds of many men.

It is only when science asks why, instead of simply describing how, that it becomes more than technology. When it asks why, it discovers Relativity. When it only shows how, it invents the atom bomb, and then puts its hands over its eye and says, 'My God what have I done?

It is the lone worker who makes the first advance in a subject: the details may be worked out by a team, but the prime idea is due to the enterprise, thought, and perception of an individual.

It is well to observe the force and virtue and consequence of discoveries, and these are to be seen nowhere more conspicuously than in those three which were unknown to the ancients, and of which the origins, although recent, are obscure and inglorious; namely, printing, gunpowder, and the magnet. For these three have changed the whole face and state of things throughout the world; the first in literature, the second in warfare, the third in navigation; whence have followed innumerable changes, insomuch that no empire, no sect, no star seems to have exerted greater power and influence in human affairs than these mechanical discoveries ... . But if a man endeavour to establish and extend the power and dominion of the human race itself over the universe, his ambition (if ambition it can be called) is without doubt both a more wholesome thing and a more noble than the other two. Now the empire of man over things depends wholly on the arts and sciences. For we cannot command nature except by obeying her.

It is worth noting that the notation facilitates discovery. This, in a most wonderful way, reduces the mind's labour.

It was a great step in science when men became convinced that, in order to understand the nature of things, they must begin by asking, not whether a thing is good or bad, noxious or beneficial, but of what kind it is? And how much is there of it? Quality and Quantity were then first recognised as the primary features to be observed in scientific inquiry.

It was quite the most incredible event that has ever happened to me in my life. It was almost as incredible as if you fired a 15-inch shell at a piece of tissue paper and it came back and hit you.
[Recalling in 1936 the discovery of the nucleus in 1909, when some alpha particles were observed instead of travelling through a very thin gold foil were seen to rebound backward, as if striking something much more massive than the particles themselves.]

Just by studying mathematics we can hope to make a guess at the kind of mathematics that will come into the physics of the future ... If someone can hit on the right lines along which to make this development, it m may lead to a future advance in which people will first discover the equations and then, after examining them, gradually learn how to apply the ... M own belief is that this is a more likely line of progress than trying to guess at physical pictures.

Laws of Serendi[ity:
(1) In order to discover anything, you must be looking for something.
(2) If you wish to make an improved product, you must already be engaged in making an inferior one.

Man carries the world in his head, the whole astronomy and chemistry suspended in a thought. Because the history of nature is charactered in his brain, therefore he is the prophet and discoverer of her secrets. Every known fact in natural science was divined by the presentiment of somebody, before it was actually verified.

Many discoveries must have been stillborn or smothered at birth. We know only those which survived.

Mathematical discoveries, like springtime violets in the woods, have their season which no human can hasten or retard.

May every young scientist remember ... and not fail to keep his eyes open for the possibility that an irritating failure of his apparatus to give consistent results may once or twice in a lifetime conceal an important discovery.
Commenting on the discovery of thoron gas because one of Rutherford's students had found his measurements of the ionizing property of thorium were variable. His results even seemed to relate to whether the laboratory door was closed or open. After considering the problem, Rutherford realized a radioactive gas was emitted by thorium, which hovered close to the metal sample, adding to its radioactivity—unless it was dissipated by air drafts from an open door. (Thoron was later found to be argon.)

Medicinal discovery,
It moves in mighty leaps,
It leapt straight past the common cold
And gave it us for keeps.

More discoveries have arisen from intense observation of very limited material than from statistics applied to large groups. The value of the latter lies mainly in testing hypotheses arising from the former. While observing one should cultivate a speculative, contemplative attitude of mind and search for clues to be followed up. Training in observation follows the same principles as training in any activity. At first one must do things consciously and laboriously, but with practice the activities gradually become automatic and unconscious and a habit is established. Effective scientific observation also requires a good background, for only by being familiar with the usual can we notice something as being unusual or unexplained.

Most of the crackpot papers which are submitted to The Physical Review are rejected, not because it is impossible to understand them, but because it is possible. Those which are impossible to understand are usually published. When the great innovation appears, it will almost certainly be in a muddled, incomplete and confusing form. To the discoverer himself it will be only half-understood; to everybody else it will be a mystery. For any speculation which does not at first glance look crazy, there is no hope.

My view of the matter, for what it is worth, is that there is no such thing as a logical method of having new ideas, or a logical reconstruction of this process. My view may be expressed by saying that every discovery contains an 'irrational element,' or 'a creative intuition,' in Bergson's sense. In a similar way Einstein speaks of the 'search for those highly universal laws ... from which a picture of the world can be obtained by pure deduction. There is no logical path.' he says, 'leading to these ... laws. They can only be reached by intuition, based upon something like an intellectual love (Einfühlung) of the objects of experience.' (1959)

Next came the patent laws. These began in England in 1624, and in this country with the adoption of our Constitution. Before then any man [might] instantly use what another man had invented, so that the inventor had no special advantage from his own invention. The patent system changed this, secured to the inventor for a limited time exclusive use of his inventions, and thereby added the fuel of interest to the fire of genius in the discovery and production of new and useful things.

No discovery of mine has made, or is likely to make, directly or indirectly, for good or ill, the least difference to the amenity of the world.

No man of science wants merely to know. He acquires knowledge to appease his passion for discovery. He does not discover in order to know, he knows in order to discover.

No one believes an hypothesis except its originator but everyone believes an experiment except the experimenter. Most people are ready to believe something based on experiment but the experimenter knows the many little things that could have gone wrong in the experiment. For this reason the discoverer of a new fact seldom feels quite so confident of it as others do. On the other hand other people are usually critical of an hypothesis, whereas the originator identifies himself with it and is liable to become devoted to it.

No one can take from us the joy of the first becoming aware of something, the so-called discovery. But if we also demand the honor, it can be utterly spoiled for us, for we are usually not the first. What does discovery mean, and who can say that he has discovered this or that? After all it's pure idiocy to brag about priority; for it's simply unconscious conceit, not to admit frankly that one is a plagiarist.

No-one really thought of fission before its discovery.

None of the great discoveries was made by a 'specialist' or a 'researcher'.

Not that we may not, to explain any Phenomena of Nature, make use of any probable Hypothesis whatsoever: Hypotheses, if they are well made, are at least great helps to the Memory, and often direct us to new discoveries. But my Meaning is, that we should not take up anyone too hastily, (which the Mind, that would always penetrate into the Causes of Things, and have Principles to rest on, is very apt to do,) till we have very well examined Particulars, and made several Experiments, in that thing which we would explain by our Hypothesis, and see whether it will agree to them all; whether our Principles will carry us quite through, and not be as inconsistent with one Phenomenon of Nature, as they seem to accommodate and explain another.

One sometimes finds what one is not looking for.

Only those works which are well-written will pass to posterity: the amount of knowledge, the uniqueness of the facts, even the novelty of the discoveries are no guarantees of immortality ... These things are exterior to a man but style is the man himself.

Perfect concordance among reformers is not to be expected; and men who are honestly struggling towards the light cannot hope to attain at one bound to the complete truth. There is always a danger lest the fascination of a new discovery should lead us too far. Men of science, being human, are apt, like lovers, to exaggerate the perfections and be a little blind to the faults of the object of their choice.

Perspective is a most subtle discovery in mathematical studies, for by means of lines it causes to appear distant that which is near, and large that which is small.

Progress in science depends on new techniques, new discoveries and new ideas, probably in that order.

Research is industrial prospecting. The oil prospectors use every scientific means to find new paying wells. Oil is found by each one of a number of methods. My own group of men are prospecting in a different field, using every possible scientific means. We believe there are still things left to be discovered. We have only stumbled upon a few barrels of physical laws from the great pool of knowledge. Some day we are going to hit a gusher.

Researchers keep identifying new species, but they have no idea about the life cycle of a given species or its other hosts. They cut open an animal and find a new species. Where did it come from? What effect does it have on its host? What is its next host? They don't know and they don't have time to find out, because there are too many other species waiting to be discovered and described.

Science arises from the discovery of Identity amid Diversity.

Science is best defined as a careful, disciplined, logical search for knowledge about any and all aspects of the universe, obtained by examination of the best available evidence and always subject to correction and improvement upon discovery of better evidence. What's left is magic. And it doesn't work.

Science unfolded her treasures and her secrets to the desperate demands of men, and placed in their hands agencies and apparatus almost decisive in their character.
Reflecting on the outcome of World War I, and an ominous future.

Scientific development depends in part on a process of non-incremental or revolutionary change. Some revolutions are large, like those associated with the names of Copernicus, Newton, or Darwin, but most are much smaller, like the discovery of oxygen or the planet Uranus. The usual prelude to changes of this sort is, I believed, the awareness of anomaly, of an occurrence or set of occurrences that does not fit existing ways of ordering phenomena. The changes that result therefore require 'putting on a different kind of thinking-cap', one that renders the anomalous lawlike but that, in the process, also transforms the order exhibited by some other phenomena, previously unproblematic.

Scientific discovery and scientific knowledge have been achieved only by those who have gone in pursuit of them without any practical purpose whatsoever in view.

Scientific discovery consists in the interpretation for our own convenience of a system of existence which has been made with no eye to our convenience at all.

Scientific progress is the discovery of a more and more comprehensive simplicity... The previous successes give us confidence in the future of science: we become more and more conscious of the fact that the universe is cognizable.

Speaking one day to Monsieur de Buffon, on the present ardor of chemical inquiry, he affected to consider chemistry but as cookery, and to place the toils of the laboratory on the footing with those of the kitchen. I think it, on the contrary, among the most useful of sciences, and big with future discoveries for the utility and safety of the human race.

Speculations apparently the most unprofitable have almost invariably been those from which the greatest practical applications have emanated.

Standard mathematics has recently been rendered obsolete by the discovery that for years we have been writing the numeral five backward. This has led to reevaluation of counting as a method of getting from one to ten. Students are taught advanced concepts of Boolean algebra, and formerly unsolvable equations are dealt with by threats of reprisals.

The alchemists in their search for gold discovered other things [of greater value].

The Columbia is lost; there are no survivors. … In an age when space flight has come to seem almost routine, it is easy to overlook the dangers of travel by rocket, and the difficulties of navigating the fierce outer atmosphere of the Earth. These astronauts knew the dangers, and they faced them willingly, knowing they had a high and noble purpose in life. Because of their courage and daring idealism, we will miss them all the more. ... The cause in which they died will continue. Mankind is led into the darness beyond our world by the inspiration of discovery and the longing to understand. Our journey into space will go on.

The deep study of nature is the most fruitful source of mathematical discoveries. By offering to research a definite end, this study has the advantage of excluding vague questions and useless calculations; besides it is a sure means of forming analysis itself and of discovering the elements which it most concerns us to know, and which natural science ought always to conserve.

The discovery of natural law is a meeting with God.

The discovery of one star is the promise of another.

The discovery which has been pointed to by theory is always one of profound interest and importance, but it is usually the close and crown of a long and fruitful period, whereas the discovery which comes as a puzzle and surprise usually marks a fresh epoch and opens a new chapter in science.

The earth's becoming at a particular period the residence of human beings, was an era in the moral, not in the physical world?that our study and contemplation of the earth, and the laws which govern its animate productions, ought no more to be considered in the light of a disturbance or deviation from the system, than the discovery of the satellites of Jupiter should be regarded as a physical event in the history of those heavenly bodies, however influential they may have become from that time in advancing the progress of sound philosophy among men.

The final discovery is the discovery of knowledge.

The first steps in the path of discovery, and the first approximate measures, are those which add most to the existing knowledge of mankind.

The folly of mistaking a paradox for a discovery, a metaphor for a proof, a torrent of verbiage for a spring of capital truths, and oneself for an oracle, is inborn in us.

The future mathematician ... should solve problems, choose the problems which are in his line, meditate upon their solution, and invent new problems. By this means, and by all other means, he should endeavor to make his first important discovery: he should discover his likes and dislikes, his taste, his own line.

The greatest obstacle to discovery is not ignorance—it is the illusion of knowledge.

The important thing in science is not so much to obtain new facts as to discover new ways of thinking about them.

The intellect has little to do on the road to discovery. There comes a leap in consciousness, call it intuition or what you will, and the solution comes to you and you don’t know why or how.

The life and soul of science is its practical application, and just as the great advances in mathematics have been made through the desire of discovering the solution of problems which were of a highly practical kind in mathematical science, so in physical science many of the greatest advances that have been made from the beginning of the world to the present time have been made in the earnest desire to turn the knowledge of the properties of matter to some purpose useful to mankind.

The major credit I think Jim and I deserve ... is for selecting the right problem and sticking to it. It's true that by blundering about we stumbled on gold, but the fact remains that we were looking for gold. Both of us had decided, quite independently of each other, that the central problem in molecular biology was the chemical structure of the gene. ... We could not see what the answer was, but we considered it so important that we were determined to think about it long and hard, from any relevant point of view.

The mind can proceed only so far upon what it knows and can prove. There comes a point where the mind takes a higher plane of knowledge, but can never prove how it got there. All great discoveries have involved such a leap

The most important discoveries will provide answers to questions that we do not yet know how to ask and will concern objects we have not yet imagined.

The principal goal of education is to create men who are capable of doing new things, not simply of repeating what other generations have done—men who are creative, inventive, and discovers. The second goal of education is to form minds which can be critical, can verify, and not accept everything they are offered.

The progress of science depends less than is usually believed on the efforts and performance of the individual genius ... many important discoveries have been made by men of ordinary talents, simply because chance had made them, at the proper time and in the proper place and circumstances, recipients of a body of doctrines, facts and techniques that rendered almost inevitable the recognition of an important phenomenon. It is surprising that some historian has not taken malicious pleasure in writing an anthology of 'one discovery' scientists. Many exciting facts have been discovered as a result of loose thinking and unimaginative experimentation, and described in wrappings of empty words. One great discovery does not betoken a great scientist; science now and then selects insignificant standard bearers to display its banners.

The role of hypothesis in research can be discussed more effectively if we consider first some examples of discoveries which originated from hypotheses. One of the best illustrations of such a discovery is provided by the story of Christopher Columbus' voyage; it has many of the features of a classic discovery in science. (a) He was obsessed with an idea—that since the world is round he could reach the Orient by sailing West, (b) the idea was by no means original, but evidently he had obtained some additional evidence from a sailor blown off his course who claimed to have reached land in the west and returned, (c) he met great difficulties in getting someone to provide the money to enable him to test his idea as well as in the actual carrying out of the experimental voyage, (d) when finally he succeeded he did not find the expected new route, but instead found a whole new world, (e) despite all evidence to the contrary he clung to the bitter end to his hypothesis and believed that he had found the route to the Orient, (f) he got little credit or reward during his lifetime and neither he nor others realised the full implications of his discovery, (g) since his time evidence has been brought forward showing that he was by no means the first European to reach America.

The seeds of great discoveries are constantly floating around us, but they only take root in minds well-prepared to receive them.

The seeds of great discovery are constantly floating around us, but they only take root in minds well prepared to receive them.

The true method of discovery is like the flight of an aeroplane. It starts from the ground of particular observation; it makes a flight in the thin air of imaginative generalization; and it again lands for renewed observation rendered acute by rational interpretation.

The University of Cambridge, in accordance with that law of its evolution, by which, while maintaining the strictest continuity between the successive phases of its history, it adapts itself with more or less promptness to the requirements of the times, has lately instituted a course of Experimental Physics.

The various reasons which we have enumerated leas us to believe that the new radio-active substance contains a new element which we propose to give the name of radium.

There is no logical staircase running from the physics of 10^-28 cm. to the physics of 10²⁸ light-years.

There is no reason why the history and philosophy of science should not be taught in such a way as to bring home to all pupils the grandeur of science and the scope of its discoveries.

There is nothing new to be discovered in physics now. All that remains is more and more precise measurement.

They are ill discoverers that think there is no land, when they can see nothing but sea.

This missing science of heredity, this unworked mine of knowledge on the borderland of biology and anthropology, which for all practical purposes is as unworked now as it was in the days of Plato, is, in simple truth, ten times more important to humanity than all the chemistry and physics, all the technical and indsutrial science that ever has been or ever will be discovered.

This therefore is Mathematics:
She reminds you of the invisible forms of the soul;
She gives life to her own discoveries;
She awakens the mind and purifies the intellect;
She brings light to our intrinsic ideas;
She abolishes oblivion and ignorance which are ours by birth...

To make a discovery is not necessarily the same as to understand a discovery.

To me there never has been a higher source of honour or distinction than that connected with advances in science. I have not possessed enough of the eagle in my character to make a direct flight to the loftiest altitudes in the social world; and I certainly never endeavored to reach those heights by using the creeping powers of the reptile, who in ascending, generally chooses the dirtiest path, because it is the easiest.

Under the Providence of God, our means of education are the grand machinery by which the 'raw material' of human nature can be worked up into inventors and discoverers, into skilled artisans and scientific farmers, into scholars and jurists, into the founders of benevolent institutions, and the great expounders of ethical and theological science.

We do not live in a time when knowledge can be extended along a pathway smooth and free from obstacles, as at the time of the discovery of the infinitesimal calculus, and in a measure also when in the development of projective geometry obstacles were suddenly removed which, having hemmed progress for a long time, permitted a stream of investigators to pour in upon virgin soil. There is no longer any browsing along the beaten paths; and into the primeval forest only those may venture who are equipped with the sharpest tools.

We must not forget that when radium was discovered no one knew that it would prove useful in hospitals. The work was one of pure science. And this is a proof that scientific work must not be considered from the point of view of the direct usefulness of it. It must be done for itself, for the beauty of science, and then there is always the chance that a scientific discovery may become like the radium a benefit for humanity.

What struck me most in England was the perception that only those works which have a practical tendency awake attention and command respect, while the purely scientific, which possess far greater merit are almost unknown. And yet the latter are the proper source from which the others flow. Practice alone can never lead to the discovery of a truth or a principle. In Germany it is quite the contrary. Here in the eyes of scientific men no value, or at least but a trifling one, is placed upon the practical results. The enrichment of science is alone considered worthy attention.

Wheeler hopes that we can discover, within the context of physics, a principle that will enable the universe to come into existence 'of its own accord'. In his search for such a theory, he remarks: 'No guiding principle would seem more powerful than the requirement that it should provide the universe with a way to come into being.'. Wheeler likened this 'self-causing' universe to a self-excited circuit in electronics.

When adults first become conscious of something new, they usually either attack or try to escape from it ... Attack includes such mild forms as ridicule, and escape includes merely putting out of mind.

When Galileo caused balls, the weights of which he had himself previously determined, to roll down an inclined plane; when Torricelli made the air carry a weight which he had calculated beforehand to be equal to that of a definite volume of water; or in more recent times, when Stahl changed metal into lime, and lime back into metal, by withdrawing something and then restoring it, a light broke upon all students of nature. They learned that reason has insight only into that which it produces after a plan of its own, and that it must not allow itself to be kept, as it were, in nature's leading-strings, but must itself show the way with principles of judgement based upon fixed laws, constraining nature to give answer to questions of reason's own determining. Accidental observations, made in obedience to no previously thought-out plan, can never be made to yield a necessary law, which alone reason is concerned to discover.

When I investigate and when I discover that the forces of the heavens and the planets are within ourselves, then truly I seem to be living among the gods.

When you start in science, you are brainwashed into believing how careful you must be, and how difficult it is to discover things. There's something that might be called the 'graduate student syndrome'; graduate students hardly believe they can make a discovery.

When young Galileo, then a student at Pisa, noticed one day during divine service a chandelier swinging backwards and forwards, and convinced himself, by counting his pulse, that the duration of the oscillations was independent of the arc through which it moved, who could know that this discovery would eventually put it in our power, by means of the pendulum, to attain an accuracy in the measurement of time till then deemed impossible, and would enable the storm-tossed seaman in the most distant oceans to determine in what degree of longitude he was sailing?

Whether one show one's self a man of genius in science or compose a song, the only point is, whether the thought, the discovery, the deed, is living and can live on.

While working with staphylococcus variants a number of culture-plates were set aside on the laboratory bench and examined from time to time. In the examinations these plates were necessarily exposed to the air and they became contaminated with various micro-organisms. It was noticed that around a large colony of a contaminating mould the staphylococcus colonies became transparent and were obviously undergoing lysis. Subcultures of this mould were made and experiments conducted with a view to ascertaining something of the properties of the bacteriolytic substance which had evidently been formed in the mould culture and which had diffused into the surrounding medium. It was found that broth in which the mould had been grown at room temperature for one or two weeks had acquired marked inhibitory, bacteriocidal and bacteriolytic properties to many of the more common pathogenic bacteria.

Why, sir, there is every probability that you will soon be able to tax it!
Said to William Gladstone, the Chancellor of the Exchequer, when he asked about the practical worth of electricity.

Wonder was the motive that led people to philosophy ... wonder is a kind of desire in knowledge. It is the cause of delight because it carries with it the hope of discovery.

Yet, in holding scientific research and discovery in respect, as we should, we must also be alert to the equal and opposite danger that public policy could itself become the captive of a scientific-technological elite.

You can hardly imagine how I am struggling to exert my poetical ideas just now for the discovery of analogies & remote figures respecting the earth, Sun & all sorts of things—for I think it is the true way (corrected by judgement) to work out a discovery.

[The more science discovers and] the more comprehension it gives us of the mechanisms of existence, the more clearly does the mystery of existence itself stand out.