A doctor who cannot take a good history and a patient who cannot give one are in danger of giving and receiving bad treatment.

A physician's subject of study is necessarily the patient, and his first field for observation is the hospital. But if clinical observation teaches him to know the form and course of diseases, it cannot suffice to make him understand their nature; to this end he must penetrate into the body to find which of the internal parts are injured in their functions. That is why dissection of cadavers and microscopic study of diseases were soon added to clinical observation. But to-day these various methods no longer suffice; we must push investigation further and, in analyzing the elementary phenomena of organic bodies, must compare normal with abnormal states. We showed elsewhere how incapable is anatomy alone to take account of vital phenenoma, and we saw that we must add study of all physico-chemical conditions which contribute necessary elements to normal or pathological manifestations of life. This simple suggestion already makes us feel that the laboratory of a physiologist-physician must be the most complicated of all laboratories, because he has to experiment with phenomena of life which are the most complex of all natural phenomena.

An observant parent’s evidence may be disproved but should never be ignored.

As soon as we got rid of the backroom attitude and brought our apparatus fully into the Department with an inexhaustible supply of living patients with fascinating clinical problems, we were able to get ahead really fast. Any new technique becomes more attractive if its clinical usefulness can be demonstrated without harm, indignity or discomfort to the patient... Anyone who is satisfied with his diagnostic ability and with his surgical results is unlikely to contribute much to the launching of a new medical science. He should first be consumed with a divine discontent with things as they are. It greatly helps, of course, to have the right idea at the right time, and quite good ideas may come, Archimedes fashion, in one's bath..

Correct is to recognize what diseases are and whence they come; which are long and which are short; which are mortal and which are not; which are in the process of changing into others; which are increasing and which are diminishing; which are major and which are minor; to treat the diseases that can be treated, but to recognize the ones that cannot be, and to know why they cannot be; by treating patients with the former, to give them the benefit of treatment as far as it is possible.

Diagnosis is not the end, but the beginning of practice.

DIAGNOSIS, n. A physician's forecast of disease by the patient's pulse and purse.

Diseases can rarely be eliminated through early diagnosis or good treatment, but prevention can eliminate disease.

Doctor says he would be a very sick man if were still alive today.

For most diagnoses all that is needed is an ounce of knowledge, an ounce of intelligence, and a pound of thoroughness.

How many famous men be there in this our age, which make scruple to condemne these old witches, thinking it to bee nothing but a melancholike humour which corrupteth thei imagination, and filleth them with all these vaines toyes. I will not cast my selfe any further into the depth of this question, the matter craveth a man of more leisure.
Describing melancholy as the innocent affliction of those regarded as witches instead of Satanic influence, while distancing himself from the controversy.

Hypochondriac symptoms commonly occur and may, if no discernible cause for the symptom is found, be due to exaggerated needs for attention and other psychological desires.

I have clearly recorded this: for one can learn good lessons also from what has been tried but clearly has not succeeded, when it is clear why it has not succeeded.

I here present the reader with a new sign which I have discovered for detecting diseases of the chest. This consists in percussion of the human thorax, whereby, according to the character of the particular sounds then elicited, an opinion is formed of the internal state of that cavity.

I look upon a good physician, not so properly as a servant to nature, as one, that is a counsellor and friendly assistant, who, in his patient's body, furthers those motions and other things, that he judges conducive to the welfare and recovery of it; but as to those, that he perceives likely to be hurtful, either by increasing the disease, or otherwise endangering the patient, he thinks it is his part to oppose or hinder, though nature do manifestly enough seem to endeavour the exercising or carrying on those hurtful motions.

I think it's a very valuable thing for a doctor to learn how to do research, to learn how to approach research, something there isn't time to teach them in medical school. They don't really learn how to approach a problem, and yet diagnosis is a problem; and I think that year spent in research is extremely valuable to them.
On mentoring a medical student.

If migraine patients have a common and legitimate second complaint besides their migraines, it is that they have not been listened to by physicians. Looked at, investigated, drugged, charged, but not listened to.

If three simple questions and one well chosen laboratory test lead to an unambiguous diagnosis, why harry the patient with more?

If your news must be bad, tell it soberly and promptly.

In acute diseases the physician must conduct his inquiries in the following way. First he must examine the face of the patient, and see whether it is like the faces of healthy people, and especially whether it is like its usual self. Such likeness will be the best sign, and the greatest unlikeness will be the most dangerous sign. The latter will be as follows. Nose sharp, eyes hollow, temples sunken, ears cold and contracted with their lobes turned outwards, the skin about the face hard and tense and parched, the colour of the face as a whole being yellow or black.

In diagnosis, the young are positive and the middle-aged tentative; only the old have flair.

In diagnosis, think of the easy first.

In the collecting of evidence upon any medical subject, there are but three sources from which we can hope to obtain it: viz. from observation of the living subject; from examination of the dead; and from experiments upon living animals.

It would be very unsafe, unwise, and incorrect to assume that a patient either can or wants to present all aspects of his or her personality fully to the eaxminer.

Medicine deals with the states of health and disease in the human body. It is a truism of philosophy that a complete knowledge of a thing can only be obtained by elucidating its causes and antecedents, provided, of course, such causes exist. In medicine it is, therefore, necessary that causes of both health and disease should be determined.

Nowadays the clinical history too often weighs more than the man.

One of the major goals when studying specific genetic diseases is to find the primary gene product, which in turn leads to a better understanding of the biochemical basis of the disorder. The bottom line often reads, 'This may lead to effective prenatal diagnosis and eventual eradication of the disease.' But we now have the ironic situation of being able to jump right to the bottom line without reading the rest of the page, that is, without needing to identify the primary gene product or the basic biochemical mechanism of the disease. The technical capability of doing this is now available. Since the degree of departure from our previous approaches and the potential of this procedure are so great, one will not be guilty of hyperbole in calling it the 'New Genetics'.

Our purpose is to be able to measure the intellectual capacity of a child who is brought to us in order to know whether he is normal or retarded. ... We do not attempt to establish or prepare a prognosis and we leave unanswered the question of whether this retardation is curable, or even improveable. We shall limit ourselves to ascertaining the truth in regard to his present mental state.

Patients and their families will forgive you for wrong diagnoses, but will rarely forgive you for wrong prognoses; the older you grow in medicine, the more chary you get about offering iron clad prognoses, good or bad.

Shut your eyes to the medical columns of the newspapers, and you will save yourself many forebodings and symptoms.

Signs and symptoms indicate the present, past and future states of the three states of the body (health, illness, neutrality). According to Galen, knowledge of the present state is of advantage only to the patient as it helps him to follow the proper course of management. Knowledge of the past state is useful only to the physician inasmuch as its disclosure by him to the patient brings him a greater respect for his professional advice. Knowledge of the future state is useful to both. It gives an opportunity to the patient to be forewarned to adopt necessary preventative measures and it enhances the reputation of the physician by correctly forecasting the future developments.

Sir Adolph Abrams, the physician, in a lecture entitled Amanuensis, described a case history as an amalgam of false memories, rumour, innuendo and downright lies, and on these we are expected to make a diagnosis.

The comforting, if spurious, precision of laboratory results has the same appeal as the lifebelt to the weak swimmer.

The faculties developed by doing research are those most needed in diagnosis.

The further away the chronic abdominal pain in a child is from the umbilicus the more likely an organic cause.

The hypochondriac disease consists in indigestion and consequent flatulency, with anxiety or want of pleasurable sensation.

The longer I practise medicine, the more convinced I am there are only two types of cases: those that involve taking the trousers off and those that don't.

The old fashioned family physician and general practitioner ... was a splendid figure and useful person in his day; but he was badly trained, he was often ignorant, he made many mistakes, for one cannot by force of character and geniality of person make a diagnosis of appendicitis, or recognize streptococcus infection.

The patient has two sleeves, one containing a diagnostic and the other a therapeutic armamentarium; these sleeves should rarely be emptied in one move; keep some techniques in reserve; time your manoeuvres to best serve the status and special needs of your patient.

The theory of medicine, therefore, presents what is useful in thought, but does not indicate how it is to be applied in practice—the mode of operation of these principles. The theory, when mastered, gives us a certain kind of knowledge. Thus we say, for example, there are three forms of fevers and nine constitutions. The practice of medicine is not the work which the physician carries out, but is that branch of medical knowledge which, when acquired, enables one to form an opinion upon which to base the proper plan of treatment.

There is only one cardinal rule: One must always listen to the patient.

This is a mighty wonder: in the discharge from the lungs alone, which is not particularly dangerous, the patients do not despair of themselves, even although near the last.
Concerning Tuberculosis.

To be uncertain is to be uncomfortable, but to be certain is to be ridiculous.

When a man lacks mental balance in pneumonia he is said to be delirious. When he lacks mental balance without the pneumonia, he is pronounced insane by all smart doctors.

When the patient dies the kidneys may go to the pathologist, but while he lives the urine is ours. It can provide us day by day, month by month, and year by year, with a serial story of the major events going on within the kidney.