[Recalling Professor Ira Remsen's remarks (1895) to a group of his graduate students about to go out with their degrees into the world beyond the university:]
He talked to us for an hour on what was ahead of us; cautioned us against giving up the desire to push ahead by continued study and work. He warned us against allowing our present accomplishments to be the high spot in our lives. He urged us not to wait for a brilliant idea before beginning independent research, and emphasized the fact the Lavoisier's first contribution to chemistry was the analysis of a sample of gypsum. He told u that the fields in which the great masters had worked were still fruitful; the ground had only been scratched and the gleaner could be sure of ample reward.

A desire to take medicine is, perhaps, the great feature which distinguishes man from other animals.

Art includes everything that stimulates the desire to live; science, everything that sharpens the desire to know. Art, even the most disinterested, the most disembodied, is the auxiliary of life.

As the component parts of all new machines may be said to be old[,] it is a nice discriminating judgment, which discovers that a particular arrangement will produce a new and desired effect. ... Therefore, the mechanic should sit down among levers, screws, wedges, wheels, etc. like a poet among the letters of the alphabet, considering them as the exhibition of his thoughts; in which a new arrangement transmits a new idea to the world.

At the outset do not be worried about this big question—Truth. It is a very simple matter if each one of you starts with the desire to get as much as possible. No human being is constituted to know the truth, the whole truth, and nothing but the truth; and even the best of men must be content with fragments, with partial glimpses, never the full fruition. In this unsatisfied quest the attitude of mind, the desire, the thirst—a thirst that from the soul must arise!—the fervent longing, are the be-all and the end-all.

First get a clear notion of what you desire to accomplish and then in all probability you will succeed in doing it.

For myself, I found that I was fitted for nothing so well as for the study of Truth; as having a mind nimble and versatile enough to catch the resemblances of things (which is the chief point) , and at the same time steady enough to fix and distinguish their subtler differences; as being gifted by nature with desire to seek, patience to doubt, fondness to meditate, slowness to assert, readiness to reconsider, carefulness to dispose and set in order; and as being a man that neither affects what is new nor admires what is old, and that hates every kind of imposture. So I thought my nature had a kind of familiarity and relationship with Truth.

From my earliest childhood I nourished and cherished the desire to make a creditable journey in a new country, and write such a respectable account of its natural history as should give me a niche amongst the scientific explorers of the globe I inhabit, and hand my name down as a useful contributor of original matter.

He that desireth to acquire any art or science seeketh first those means by which that art or science is obtained.

If history and science have taught us anything, it is that passion and desire are not the same as truth. The human mind evolved to believe in the gods. It did not evolve to believe in biology.

Imagination is the beginning of creation. You imagine what you desire, you will what you imagine and at last you create what you will.

In matters of science, curiosity gratified begets not indolence, but new desires.

It is the desire for explanations that are at once systematic and controllable by factual evidence that generates science; and it is the organization and classification of knowledge on the basis of explanatory principles that is the distinctive goal of the sciences.

It is very desirable to have a word to express the Availability for work of the heat in a given magazine; a term for that possession, the waste of which is called Dissipation. Unfortunately the excellent word Entropy, which Clausius has introduced in this connexion, is applied by him to the negative of the idea we most naturally wish to express. It would only confuse the student if we were to endeavour to invent another term for our purpose. But the necessity for some such term will be obvious from the beautiful examples which follow. And we take the liberty of using the term Entropy in this altered sense ... The entropy of the universe tends continually to zero.

Mathematics as an expression of the human mind reflects the active will, the contemplative reason, and the desire for aesthetic perfection. Its basic elements are logic and intuition, analysis and construction, generality and individuality. Though different traditions may emphasize different aspects, it is only the interplay of these antithetic forces and the struggle for their synthesis that constitute the life, usefulness, and supreme value of mathematical science.

My belief (is) that one should take a minimum of care and preparation over first experiments. If they are unsuccessful one is not then discouraged since many possible reasons for failure can be thought of, and improvements can be made. Much can often be learned by the repetition under different conditions, even if the desired result is not obtained. If every conceivable precaution is taken at first, one is often too discouraged to proceed at all.

Nothing retains less of desire in art, in science, than this will to industry, booty, possession.

One of the strongest motives that lead men to art and science is escape from everyday life with its painful crudity and hopeless dreariness, from the fetters of one's own ever-shifting desires.

Our novice runs the risk of failure without additional traits: a strong inclination toward originality, a taste for research, and a desire to experience the incomparable gratification associated with the act of discovery itself.

Religious leaders and men of science have the same ideals; they want to understand and explain the universe of which they are part; they both earnestly desire to solve, if a solution be ever possible, that great riddle: Why are we here?

Science has taught us to think the unthinkable. Because when nature is the guide—rather than a priori prejudices, hopes, fears or desires—we are forced out of our comfort zone. One by one, pillars of classical logic have fallen by the wayside as science progressed in the 20th century, from Einstein's realization that measurements of space and time were not absolute but observer-dependent, to quantum mechanics, which not only put fundamental limits on what we can empirically know but also demonstrated that elementary particles and the atoms they form are doing a million seemingly impossible things at once.

Science is not the enemy of humanity but one of the deepest expressions of the human desire to realize that vision of infinite knowledge. Science shows us that the visible world is neither matter nor spirit; the visible world is the invisible organization of energy.

Science only means knowledge; and for [Greek] ancients it did only mean knowledge. Thus the favorite science of the Greeks was Astronomy, because it was as abstract as Algebra. ... We may say that the great Greek ideal was to have no use for useful things. The Slave was he who learned useful things; the Freeman was he who learned useless things. This still remains the ideal of many noble men of science, in the sense they do desire truth as the great Greeks desired it; and their attitude is an external protest against vulgarity of utilitarianism.

Some proofs command assent. Others woo and charm the intellect. They evoke delight and an overpowering desire to say, 'Amen, Amen'.

The great object I desire to accomplish by this institution [the Cooper Institute], is to open the avenues of scientific knowledge to the youth of our country, so unfolding the volume of Nature, that the young may see the beauties of creation.

The King saw them with no common satisfaction, expressing his desire in no particular to have yt Stellar fish engraven and printed. We wish very much, Sir, yt you could procure for us a particular description of yesd Fish, viz. whether it be common there; what is observable in it when alive; what colour it then hath; what kind of motion in the water; what use it maketh of all that curious workmanship, wch Nature hath adorn'd it with?

The origin of all science is the desire to know causes, and the origin of all false science and imposture is the desire to accept false causes rather than none; or, which is the same thing, in the unwillingness to acknowledge our own ignorance.

The scientific attitude of mind involves a sweeping away of all other desires in the interest of the desire to know.

The theory of the method of knowing which is advanced in these pages may be termed pragmatic. ... Only that which has been organized into our disposition so as to enable us to adapt the environment to our needs and adapt our aims and desires to the situation in which we live is really knowledge.

The trained nurse has given nursing the human, or shall we say, the divine touch, and made the hospital desirable for patients with serious ailments regardless of their home advantages.

The value the world sets upon motives is often grossly unjust and inaccurate. Consider, for example, two of them: mere insatiable curiosity and the desire to do good. The latter is put high above the former, and yet it is the former that moves some of the greatest men the human race has yet produced: the scientific investigators. What animates a great pathologist? Is it the desire to cure disease, to save life? Surely not, save perhaps as an afterthought. He is too intelligent, deep down in his soul, to see anything praiseworthy in such a desire. He knows by life-long observation that his discoveries will do quite as much harm as good, that a thousand scoundrels will profit to every honest man, that the folks who most deserve to be saved will probably be the last to be saved. No man of self-respect could devote himself to pathology on such terms. What actually moves him is his unquenchable curiosity–his boundless, almost pathological thirst to penetrate the unknown, to uncover the secret, to find out what has not been found out before. His prototype is not the liberator releasing slaves, the good Samaritan lifting up the fallen, but the dog sniffing tremendously at an infinite series of rat-holes.

We do not ask what hope of gain makes a little bird warble, since we know that it takes delight in singing because it is for that very singing that the bird was made, so there is no need to ask why the human mind undertakes such toil in seeking out these secrets of the heavens. ... And just as other animals, and the human body, are sustained by food and drink, so the very spirit of Man, which is something distinct from Man, is nourished, is increased, and in a sense grows up on this diet of knowledge, and is more like the dead than the living if it is touched by no desire for these things.

We have reason not to be afraid of the machine, for there is always constructive change, the enemy of machines, making them change to fit new conditions.
We suffer not from overproduction but from undercirculation. You have heard of technocracy. I wish I had those fellows for my competitors. I'd like to take the automobile it is said they predicted could be made now that would last fifty years. Even if never used, this automobile would not be worth anything except to a junkman in ten years, because of the changes in men's tastes and ideas. This desire for change is an inherent quality in human nature, so that the present generation must not try to crystallize the needs of the future ones.
We have been measuring too much in terms of the dollar. What we should do is think in terms of useful materials—things that will be of value to us in our daily life.

We need go back only a few centuries to find the great mass of people depending on religion for the satisfaction of practically all their wishes. From rain out of the sky to good health on earth, they sought their desires at the altars of their gods. Whether they wanted large families, good crops, freedom from pestilence, or peace of mind, they conceived themselves as dependent on the favor of heaven. Then science came with its alternative, competitive method of getting what we want. That is science’s most important attribute. As an intellectual influence it is powerful enough, but as a practical way of achieving man’s desires it is overwhelming.

What animates a great pathologist? Is it the desire to cure disease, to save life? Surely not, save perhaps as an afterthought. He is too intelligent, deep in his soul, to see anything praiseworthy in such a desire. He knows from life-long observation that his discoveries will do quite as much harm as good, that a thousand scoundrels will profit to every honest man, that the folks who most deserve to be saved will probably be the last to be saved. ... What actually moves him is his unquenchable curiosity—his boundless, almost pathological thirst to penetrate the unknown, to uncover the secret, to find out what has not been found out before. ... [like] the dog sniffing tremendously at an infinite series of rat-holes. ... And yet he stands in the very front rank of the race

[Regarding evolution believers:] Their business is not with the possible, but the actual—not with a world which might be, but with a world that is. This they explore with a courage not unmixed with reverence, and according to methods which, like the quality of a tree, are tested by their fruits. They have but one desire—to know the truth. They have but one fear—to believe a lie.

[T]he human desire to escape the flesh, which took one form in asceticism, might take another form in the creation of machines. Thus, the wish to rise above the bestial body manifested itself not only in angels but in mechanical creatures. Certainly, once machines existed, humans clearly attached to them feelings of escape from the flesh.