A foolish consistency is the hobgoblin of little minds, adored by little statesmen and philosophers and divines.

May every young scientist remember ... and not fail to keep his eyes open for the possibility that an irritating failure of his apparatus to give consistent results may once or twice in a lifetime conceal an important discovery.
Commenting on the discovery of thoron gas because one of Rutherford's students had found his measurements of the ionizing property of thorium were variable. His results even seemed to relate to whether the laboratory door was closed or open. After considering the problem, Rutherford realized a radioactive gas was emitted by thorium, which hovered close to the metal sample, adding to its radioactivity—unless it was dissipated by air drafts from an open door. (Thoron was later found to be argon.)

The institutional goal of science is the extension of certified knowledge. The technical methods employed toward this end provide the relevant definition of knowledge: empirically confirmed and logically consistent predictions. The institutional imperatives (mores) derive from the goal and the methods. The entire structure of technical and moral norms implements the final objective. The technical norm of empirical evidence, adequate, valid and reliable, is a prerequisite for sustained true prediction; the technical norm of logical consistency, a prerequisite for systematic and valid prediction. The mores of science possess a methodologic rationale but they are binding, not only because they are procedurally efficient, but because they are believed right and good. They are moral as well as technical prescriptions. Four sets of institutional imperatives–universalism, communism, disinterestedness, organized scepticism–comprise the ethos of modern science.