Chemotherapy Quotes (2)
In order to pursue chemotherapy successfully we must look for substances which possess a high affinity and high lethal potency in relation to the parasites, but have a low toxicity in relation to the body, so that it becomes possible to kill the parasites without damaging the body to any great extent. We want to hit the parasites as selectively as possible. In other words, we must learn to aim and to aim in a chemical sense. The way to do this is to synthesize by chemical means as many derivatives as possible of relevant substances.
'Ueber den jetzigen Stand der Chemotherapie'. Berichte der Deutschen Chemischen Gesellschagt, 1909, 42, 17-47. Translated in B. Holmstedt and G. Liljestrand (eds.), Readings in Pharmacology (1963), 286.
It has been shown to be possible, by deliberately planned and chemotherapeutic approach, to discover curative agents which act specifically and aetiologically against diseases due to protozoal infections, and especially against the spirilloses, and amongst these against syphilis in the first place. Further evidence for the specificity of the action of dihydroxydiaminoarsenobenzene [Salvarsan '606'] is the disappearance of the Wasserman reaction, which reaction must ... be regarded as indicative of a reaction of the organism to the constituents of the spirochaetes.
P. Ehrlich and S. Hata, 'Closing Notes to the Experimental Chemotherapy of Spirilloses', 1910. Reprinted in F. Himmelweit (ed.), The Collected Papers of Paul Ehrlich (1957), Vol. 3, 302.
See also: | Immunology (9)
