All the inventions that the world contains,
Were not by reason first found out, nor brains;
But pass for theirs who had the luck to light
Upon them by mistake or oversight.

An immune system of enormous complexity is present in all vertebrate animals. When we place a population of lymphocytes from such an animal in appropriate tissue culture fluid, and when we add an antigen, the lymphocytes will produce specific antibody molecules, in the absense of any nerve cells. I find it astonishing that the immune system embodies a degree of complexity which suggests some more or less superficial though striking analogies with human language, and that this cognitive system has evolved and functions without assistance of the brain.

And if incision of the temple is made on the left, spasm seizes the parts on the right, while if the incision is on the right, spasm seizes the parts on the left.

And men ought to know that from nothing else but thence [from the brain] come joys, delights, laughter and sports, and sorrows, griefs, despondency, and lamentations. And by this, in an especial manner, we acquire wisdom and knowledge, and see and hear, and know what are foul and hat are fair, what are bad and what are good, what are sweet, and what unsavory... And by the same organ we become mad and delirious, and fears and terrors assail us... All these things we endure from the brain, when it is not healthy... In these ways I am of the opinion that the brain exercises the greatest power in the man. This is the interpreter to us of those things which emanate from the air, when it [the brain] happens to be in a sound state.

As followers of natural science we know nothing of any relation between thoughts and the brain, except as a gross correlation in time and space.

BRAIN, n. An apparatus with which we think that we think. That which distinguishes the man who is content to be something from the man who wishes to do something. A man of great wealth, or one who has been pitchforked into high station, has commonly such a headful of brain that his neighbors cannot keep their hats on. In our civilization, and under our republican form of government, brain is so highly honored that it is rewarded by exemption from the cares of office.

Each nerve cell receives connections from other nerve cells at six sites called synapses. But here is an astonishing fact—there are about one million billion connections in the cortical sheet. If you were to count them, one connection (or synapse) per second, you would finish counting some thirty-two million years after you began. Another way of getting a feeling for the numbers of connections in this extraordinary structure is to consider that a large match-head's worth of your brain contains about a billion connections. Notice that I only mention counting connections. If we consider how connections might be variously combined, the number would be hyperastronomical—on the order of ten followed by millions of zeros. (There are about ten followed by eighty zero's worth of positively charged particles in the whole known universe!)

Facts to [Herbert] Hoover's brain are as water to a sponge; they are absorbed into every tiny interstice.

For in disease the most voluntary or most special movements, faculties, etc., suffer first and most, that is in an order the exact opposite of evolution. Therefore I call this the principle of Dissolution.

For three million years we were hunter-gatherers, and it was through the evolutionary pressures of that way of life that a brain so adaptable and so creative eventually emerged. Today we stand with the brains of hunter-gatherers in our heads, looking out on a modern world made comfortable for some by the fruits of human inventiveness, and made miserable for others by the scandal of deprivation in the midst of plenty.

For, every time a certain portion is destroyed, be it of the brain or of the spinal cord, a function is compelled to cease suddenly, and before the time known beforehand when it would stop naturally, it is certain that this function depends upon the area destroyed. It is in this way that I have recognized that the prime motive power of respiration has its seat in that part of the medulla oblongata that gives rise to the nerves of the eighth pair [vagi]; and it is by this method that up to a certain point it will be possible to discover the use of certain parts of the brain.

Have you tried neuroxing papers? It's a very easy and cheap process. You hold the page in front of your eyes and you let it go through there into the brain. It's much better than xeroxing.

Here I am: My brain is open.
[As an itinerant scholar, this was greeting he often gave, ready to collaborate, upon arrival at the home of any mathematician colleague.]

I am delighted that I have found a new reaction to demonstrate even to the blind the structure of the interstitial stroma of the cerebral cortex. I let the silver nitrate react with pieces of brain hardened in potassium dichromate. I have already obtained magnificent results and hope to do even better in the future.

I bet the human brain is a kludge

I consider the differences between man and animals in propensities, feelings, and intellectual faculties, to be the result of the same cause as that which we assign for the variations in other functions, viz. difference of organization; and that the superiority of man in rational endowments is not greater than the more exquisite, complicated, and perfectly developed structure of his brain, and particularly of his ample cerebral hemispheres, to which the rest of the animal kingdom offers no parallel, nor even any near approximation, is sufficient to account for.

I took this view of the subject. The medulla spinalis has a central division, and also a distinction into anterior and posterior fasciculi, corresponding with the anterior and posterior portions of the brain. Further we can trace down the crura of the cerebrum into the anterior fasciculus of the spinal marrow, and the crura of the cerebellum into the posterior fasciculus. I thought that here I might have an opportunity of touching the cerebellum, as it were, through the posterior portion of the spinal marrow, and the cerebrum by the anterior portion. To this end I made experiments which, though they were not conclusive, encouraged me in the view I had taken. I found that injury done to the anterior portion of the spinal marrow, convulsed the animal more certainly than injury done to the posterior portion; but I found it difficult to make the experiment without injuring both portions.

If materialism is true, it seems to me that we cannot know that it is true. If my opinions are the result of the chemical processes going on in my brain, they are determined by the laws of chemistry, not those of logic.

If the brain were so simple that we could understand it, we would be so simple we couldn't.

If the human mind were simple enough to understand, we'd be too simple to understand it.

In order to form for one's self a just notion of the operations which result in the production of thought, it is necessary to conceive of the brain as a peculiar organ, specially designed for the production thereof, just as the stomach is designed to effect digestion, the liver to filter the bile, the parotids and the maxillary and sublingual glands to prepare the salivary juices.

Is no one inspired by our present picture of the universe? This value of science remains unsung by singers: you are reduced to hearing not a song or poem, but an evening lecture about it. This is not yet a scientific age.
Perhaps one of the reasons for this silence is that you have to know how to read music. For instance, the scientific article may say, 'The radioactive phosphorus content of the cerebrum of the rat decreases to one- half in a period of two weeks.' Now what does that mean?
It means that phosphorus that is in the brain of a rat—and also in mine, and yours—is not the same phosphorus as it was two weeks ago. It means the atoms that are in the brain are being replaced: the ones that were there before have gone away.
So what is this mind of ours: what are these atoms with consciousness? Last week's potatoes! They now can remember what was going on in my mind a year ago—a mind which has long ago been replaced. To note that the thing I call my individuality is only a pattern or dance, that is what it means when one discovers how long it takes for the atoms of the brain to be replaced by other atoms. The atoms come into my brain, dance a dance, and then go out—there are always new atoms, but always doing the same dance, remembering what the dance was yesterday.

It has been said that he who was the first to abuse his fellow-man instead of knocking out his brains without a word, laid thereby the basis of civilisation.

It is because of his brain that [modern man] has risen above the animals. Guess which animals he has risen above.

It is distinctly proved, by this series of observations, that the reflex function exists in the medulla independently of the brain; in the medulla oblongata independently of the medulla spinalis; and in the spinal marrow of the anterior extremities, of the posterior extremities, and of the tail, independently of that of each other of these parts, respectively. There is still a more interesting and satisfactory mode of performing the experiment: it is to divide the spinal marrow between the nerves of the superior and inferior extremities. We have then two modes of animal life : the first being the assemblage of the voluntary and respiratory powers with those of the reflex function and irritability; the second, the two latter powers only: the first are those which obtain in the perfect animal, the second those which animate the foetus. The phenomena are precisely what might have been anticipated. If the spinal marrow be now destroyed, the irritability alone remains,—all the other phenomena having ceased.

It is strongly suspected that a NEWTON or SHAKESPEARE excels other mortals only by a more ample development of the anterior cerebral lobes, by having an extra inch of brain in the right place.

It seems a miracle that young children easily learn the language of any environment into which they were born. The generative approach to grammar, pioneered by Chomsky, argues that this is only explicable if certain deep, universal features of this competence are innate characteristics of the human brain. Biologically speaking, this hypothesis of an inheritable capability to learn any language means that it must somehow be encoded in the DNA of our chromosomes. Should this hypothesis one day be verified, then lingusitics would become a branch of biology.

Man carries the world in his head, the whole astronomy and chemistry suspended in a thought. Because the history of nature is charactered in his brain, therefore he is the prophet and discoverer of her secrets. Every known fact in natural science was divined by the presentiment of somebody, before it was actually verified.

Man has two conditions of existence in the body. Hardly two creatures can be less alike than an infant and a man. The whole fetal state is a preparation for birth ... The human brain, in its earlier stage, resembles that of a fish: as it is developed, it resembles more the cerebral mass of a reptile; in its increase, it is like that of a bird, and slowly, and only after birth, does it assume the proper form and consistence of the human encephalon.

Men make their own history, but not just as they please. They do not choose the circumstances for themselves, but have to work upon circumstances as they find them, have to fashion the material handed down by the past. The legacy of the dead generations weighs like an alp upon the brains of the living.

Men ought to know that from the brain, and from the brain only, arise our pleasures, joys, laughter and jests, as well as our sorrows, pains, griefs and tears. Through it, in particular, we think, see, hear, and distinguish the ugly from the beautiful, the bad from the good, the pleasant from the unpleasant, in some cases using custom as a test, in others perceiving them from their utility. It is the same thing which makes us mad or delirious, inspires us with dread or fear, whether by night or by day, brings sleeplessness, inopportune mistakes, aimless anxieties, absent-mindedness, and acts that are contrary to habit. These things that we suffer all come from the brain, when it is not healthy, but becomes abnormally hot, cold, moist, or dry, or suffers any other unnatural affection to which it was not accustomed. Madness comes from its moistness.

MIND, n. A mysterious form of matter secreted by the brain. Its chief activity consists in the endeavor to ascertain its own nature, the futility of the attempt being due to the fact that it has nothing but itself to know itself with.

Nature has provided two great gifts: life and then the diversity of living things, jellyfish and humans, worms and crocodiles. I don't undervalue the investigation of commonalities but can't avoid the conclusion that diversity has been relatively neglected, especially as concerns the brain.

One most necessary function of the brain is to exert an inhibitory power over the nerve centres that lie below it, just as man exercises a beneficial control over his fellow animals of a lower order of dignity; and the increased irregular activity of the lower centres surely betokens a degeneration: it is like the turbulent, aimless action of a democracy without a head.

Pressure, no doubt, has always been a most important factor in the metamorphism of rocks; but there is, I think, at present some danger in over-estimating this, and representing a partial statement of truth as the whole truth. Geology, like many human beings, suffered from convulsions in its infancy; now, in its later years, I apprehend an attack of pressure on the brain.

Psychology is physiology above the collar button.

Research is four things: brains with which to think, eyes with which to see, machines with which to measure, and fourth, money.

Segregationalists will even argue that God was the first segregationalist. 'Red birds and blue birds don't fly together,' they contend. ...They turn to some pseudo-scientific writing and argue that the Negro's brain is smaller than the white man's brain. They do not know, or they refuse to know that the idea of an inferior or superior race has been refuted by the best evidence of the science of anthropology. Great anthropologists, like Ruth Benedict, Margaret Mead, and Melville J. Herskovits, agree that, although there may be inferior and superior individuals within all races, there is no superior or inferior race. And segregationalists refuse to acknowledge that there are four types of blood, and these four types are found within every racial group.

Sexual instinct—as emotion, idea, and impulse—is a function of the cerebral cortex. Thus far no definite region of the cortex has been proved to be exclusively the seat of sexual sensations and impulses.

Such pretensions to nicety in experiments of this nature, are truly laughable! They will be telling us some day of the WEIGHT of the MOON, even to drams, scruples and grains—nay, to the very fraction of a grain!—I wish there were infallible experiments to ascertain the quantum of brains each man possesses, and every man's integrity and candour:&mash;This is a desideratum in science which is most of all wanted.

Taking advantage of the method, found by me, of the black staining of the elements of the brain, staining obtained by the prolonged immersion of the pieces, previously hardened with potassium or ammonium bichromate, in a 0.50 or 1.0% solution of silver nitrate, I happened to discover some facts concerning the structure of the cerebral gray matter that I believe merit immediate communication.

The brain is a wonderful organ. It starts working the moment you get up in the morning and does not stop until you get into the office.

The brain is an island in an osmotically homogeneous sea.

The brain is the most complicated kilo of matter in the universe.

The brain of man, like that of all animals is double, being parted down its centre by a thin membrane. For this reason pain is not always felt in the same part of the head, but sometimes on one side, sometimes on the other, and occasionally all over.

The cerebrum I consider as the grand organ by which the mind is united to the body. Into it all the nerves from the external organs of the senses enter; and from it all the nerves which are agents of the will pass out.

The experimental investigation by which Ampere established the law of the mechanical action between electric currents is one of the most brilliant achievements in science. The whole theory and experiment, seems as if it had leaped, full grown and full armed, from the brain of the 'Newton of Electricity'. It is perfect in form, and unassailable in accuracy, and it is summed up in a formula from which all the phenomena may be deduced, and which must always remain the cardinal formula of electro-dynamics.

The fate of the physiology of the brain is independent of the truth and falsity of my assertions relative to the laws of the organization of the nervous system, in general, and of the brain in particular, just as the knowledge of the functions of a sense is independent of the knowledge of the structure of its apparatus.

The most extensive computation known has been conducted over the last billion years on a planet-wide scale: it is the evolution of life. The power of this computation is illustrated by the complexity and beauty of its crowning achievement, the human brain.

The self-same atoms which, chaotically dispersed, made the nebula, now, jammed and temporarily caught in peculiar positions, form our brains; and the 'evolution' of brains, if understood, would be simply the account of how the atoms came to be so caught and jammed.

The spark of a genius exists in the brain of the truly creative man from the hour of his birth. True genius is always inborn and never cultivated, let alone learned.

The White medullary Substance of the Brain is also the immediate Instrument, by which Ideas are presented to the Mind: Or, in other Words, whatever Changes are made in this Substance, corresponding Changes are made in our Ideas; and vice versa.

Then I had shown, in the same place, what the structure of the nerves and muscles of the human body would have to be in order for the animal spirits in the body to have the power to move its members, as one sees when heads, soon after they have been cut off, still move and bite the ground even though they are no longer alive; what changes must be made in the brain to cause waking, sleep and dreams; how light, sounds, odours, tastes, warmth and all the other qualities of external objects can impress different ideas on it through the senses; how hunger, thirst, and the other internal passions can also send their ideas there; what part of the brain should be taken as 'the common sense', where these ideas are received; what should be taken as the memory, which stores the ideas, and as the imagination, which can vary them in different ways and compose new ones and, by the same means, distribute the animal spirits to the muscles, cause the limbs of the body to move in as many different ways as our own bodies can move without the will directing them, depending on the objects that are present to the senses and the internal passions in the body. This will not seem strange to those who know how many different automata or moving machines can be devised by human ingenuity, by using only very few pieces in comparison with the larger number of bones, muscles, nerves, arteries, veins and all the other parts in the body of every animal. They will think of this body like a machine which, having been made by the hand of God, is incomparably better structured than any machine that could be invented by human beings, and contains many more admirable movements.

There cannot always be fresh fields of conquest by the knife; there must be portions of the human frame that will ever remain sacred from its intrusions, at least in the surgeon's hands. That we have already, if not quite, reached these final limits, there can be little question. The abdomen, the chest, and the brain will be forever shut from the intrusion of the wise and humane surgeon.

There must be a marsh in the brains of these men or there would not be so many frogs of wrong ideas gathered in their heads.

We have in the spinal cord the antetype (Vorbild) and the foundation for the entire structure of the brain.

While our behavior is still significantly controlled by our genetic inheritance, we have, through our brains, a much richer opportunity to blaze new behavioral and cultural pathways on short timescales.

Whoever would not remain in complete ignorance of the resources which cause him to act; whoever would seize, at a single philosophical glance, the nature of man and animals, and their relations to external objects; whoever would establish, on the intellectual and moral functions, a solid doctrine of mental diseases, of the general and governing influence of the brain in the states of health and disease, should know, that it is indispensable, that the study of the organization of the brain should march side by side with that of its functions.