...after my first feeling of revulsion had passed, I spent three of the most entertaining and instructive weeks of my life studying the fascinating molds which appeared one by one on the slowly disintegrating mass of horse-dung. Microscopic molds are both very beautiful and absorbingly interesting. The rapid growth of their spores, the way they live on each other, the manner in which the different forms come and go, is so amazing and varied that I believe a man could spend his life and not exhaust the forms or problems contained in one plate of manure.

A biophysicist talks physics to the biologists and biology to the physicists, but when he meets another biophysicist, they just discuss women.

A cell is regarded as the true biological atom.

A sound Physics of the Earth should include all the primary considerations of the earth's atmosphere, of the characteristics and continual changes of the earth's external crust, and finally of the origin and development of living organisms. These considerations naturally divide the physics of the earth into three essential parts, the first being a theory of the atmosphere, or Meteorology, the second, a theory of the earth's external crust, or Hydrogeology, and the third, a theory of living organisms, or Biology.

At lunch Francis [Crick] winged into the Eagle to tell everyone within hearing distance that we had found the secret of life.

Biological determinism is, in its essence, a theory of limits. It takes the current status of groups as a measure of where they should and must be ... We inhabit a world of human differences and predilections, but the extrapolation of these facts to theories of rigid limits is ideology.

Biology has at least 50 more interesting years.

Biology has become as unthinkable without gene-splicing techniques as sending an explorer into the jungle without a compass.
Magazine interview (1981); one year after becoming the first scientist to make bacteria produce a facsimile of human interferon.

Both biological and cultural diversity are now severely threatened and working for their preservation is a critical task.

Darwin was a biological evolutionist, because he was first a uniformitarian geologist. Biology is pre-eminent to-day among the natural sciences, because its younger sister, Geology, gave it the means.

Genetics is the first biological science which got in the position in which physics has been in for many years. One can justifiably speak about such a thing as theoretical mathematical genetics, and experimental genetics, just as in physics. There are some mathematical geniuses who work out what to an ordinary person seems a fantastic kind of theory. This fantastic kind of theory nevertheless leads to experimentally verifiable prediction, which an experimental physicist then has to test the validity of. Since the times of Wright, Haldane, and Fisher, evolutionary genetics has been in a similar position.

Genetics is to biology what atomic theory is to physics. Its principle is clear: that inheritance is based on particles and not on fluids. Instead of the essence of each parent mixing, with each child the blend of those who made him, information is passed on as a series of units. The bodies of successive generations transport them through time, so that a long-lost character may emerge in a distant descendant. The genes themselves may be older than the species that bear them.

Geology has its peculiar difficulties, from which all other sciences are exempt. Questions in chemistry may be settled in the laboratory by experiment. Mathematical and philosophical questions may be discussed, while the materials for discussion are ready furnished by our own intellectual reflections. Plants, animals and minerals, may be arranged in the museum, and all questions relating to their intrinsic principles may be discussed with facility. But the relative positions, the shades of difference, the peculiar complexions, whether continuous or in subordinate beds, are subjects of enquiry in settling the character of rocks, which can be judged of while they are in situ only.

I came to biochemistry through chemistry; I came to chemistry, partly by the labyrinthine routes that I have related, and partly through the youthful romantic notion that the natural sciences had something to do with nature. What I liked about chemistry was its clarity surrounded by darkness; what attracted me, slowly and hesitatingly, to biology was its darkness surrounded by the brightness of the givenness of nature, the holiness of life. And so I have always oscillated between the brightness of reality and the darkness of the unknowable. When Pascal speaks of God in hiding, Deus absconditus, we hear not only the profound existential thinker, but also the great searcher for the reality of the world. I consider this unquenchable resonance as the greatest gift that can be bestowed on a naturalist.

I venture to maintain, that, if the general culture obtained in the Faculty of Arts were what it ought to be, the student would have quite as much knowledge of the fundamental principles of Physics, of Chemistry, and of Biology, as he needs, before he commenced his special medical studies. Moreover, I would urge, that a thorough study of Human Physiology is, in itself, an education broader and more comprehensive than much that passes under that name. There is no side of the intellect which it does not call into play, no region of human knowledge into which either its roots, or its branches, do not extend; like the Atlantic between the Old and the New Worlds, its waves wash the shores of the two worlds of matter and of mind; its tributary streams flow from both; through its waters, as yet unfurrowed by the keel of any Columbus, lies the road, if such there be, from the one to the other; far away from that Northwest Passage of mere speculation, in which so many brave souls have been hopelessly frozen up.

If history and science have taught us anything, it is that passion and desire are not the same as truth. The human mind evolved to believe in the gods. It did not evolve to believe in biology.

In a sense cosmology contains all subjects because it is the story of everything, including biology, psychology and human history. In that single sense it can be said to contain an explanation also of time's arrow. But this is not what is meant by those who advocate the cosmological explanation of irreversibility. They imply that in some way the time arrow of cosmology imposes its sense on the thermodynamic arrow. I wish to disagree with this view. The explanation assumes that the universe is expanding. While this is current orthodoxy, there is no certainty about it. The red-shifts might be due to quite different causes. For example, when light passes through the expanding clouds of gas it will be red-shifted. A large number of such clouds might one day be invoked to explain these red shifts. It seems an odd procedure to attempt to 'explain' everyday occurrences, such as the diffusion of milk into coffee, by means of theories of the universe which are themselves less firmly established than the phenomena to be explained. Most people believe in explaining one set of things in terms of others about which they are more certain, and the explanation of normal irreversible phenomena in terms of the cosmological expansion is not in this category.

It is an old saying, abundantly justified, that where sciences meet there growth occurs. It is true moreover to say that in scientific borderlands not only are facts gathered that [are] often new in kind, but it is in these regions that wholly new concepts arise. It is my own faith that just as the older biology from its faithful studies of external forms provided a new concept in the doctrine of evolution, so the new biology is yet fated to furnish entirely new fundamental concepts of science, at which physics and chemistry when concerned with the non-living alone could never arrive.

It seems a miracle that young children easily learn the language of any environment into which they were born. The generative approach to grammar, pioneered by Chomsky, argues that this is only explicable if certain deep, universal features of this competence are innate characteristics of the human brain. Biologically speaking, this hypothesis of an inheritable capability to learn any language means that it must somehow be encoded in the DNA of our chromosomes. Should this hypothesis one day be verified, then lingusitics would become a branch of biology.

Many thanks for the sending me the book Biology of the Striped Skunk ... Frankly, I doubt whether I shall read it or not, unless I happen to have some intimate contact with a skunk which may induce me to learn more about him.

Metaphysical ghosts cannot be killed, because they cannot be touched; but they may be dispelled by dispelling the twilight in which shadows and solidities are easily confounded. The Vital Principle is an entity of this ghostly kind; and although the daylight has dissipated it, and positive Biology is no longer vexed with its visitations, it nevertheless reappears in another shape in the shadowy region of mystery which surrounds biological and all other questions.

Nothing in biology makes sense except in the light of evolution

Nothing in biology makes sense, except in the light of evolution.

Scientists themselves readily admit that they do not fully understand the consequences of our many-faceted assault upon the interwoven fabric of atmosphere, water, land and life in all its biological diversity. But things could also turn out to be worse than the current scientific best guess. In military affairs, policy has long been based on the dictum that we should be prepared for the worst case. Why should it be so different when the security is that of the planet and our long-term future?

Teleology is a lady without whom no biologist can live. Yet he is ashamed to show himself with her in public.

The development of an organism … may be considered as the execution of a 'developmental program' present in the fertilized egg. … A central task of developmental biology is to discover the underlying algorithm from the course of development.

The existence of life must be considered as an elementary fact that can not be explained, but must be taken as a starting point in biology, in a similar way as the quantum of action, which appears as an irrational element from the point of view of classical mechanical physics, taken together with the existence of elementary particles, forms the foundation of atomic physics. The asserted impossibility of a physical or chemical explanation of the function peculiar to life would in this sense be analogous to the insufficiency of the mechanical analysis for the understanding of the stability of atoms.

The fact of evolution is the backbone of biology, and biology is thus in the peculiar position of being a science founded on an improved theory, is it then a science or faith?

The time has come to link ecology to economic and human development. When you have seen one ant, one bird, one tree, you have not seen them all. What is happening to the rain forests of Madagascar and Brazil will affect us all.

The work I have done has, already, been adequately rewarded and recognized. Imagination reaches out repeatedly trying to achieve some higher level of understanding, until suddenly I find myself momentarily alone before one new corner of nature's pattern of beauty and true majesty revealed. That was my reward.

There is a strange disparity between the sciences of inert matter and those of life. Astronomy, mechanics, and physics are based on concepts which can be expressed, tersely and elegantly, in mathematical language. They have built up a universe as harmonious as the monuments of ancient Greece. They weave about it a magnificent texture of calculations and hypotheses. They search for reality beyond the realm of common thought up to unutterable abstractions consisting only of equations of symbols. Such is not the position of biological sciences. Those who investigate the phenomena of life are as if lost in an inextricable jungle, in the midst of a magic forest, whose countless trees unceasingly change their place and their shape. They are crushed under a mass of facts, which they can describe but are incapable of defining in algebraic equations.

This missing science of heredity, this unworked mine of knowledge on the borderland of biology and anthropology, which for all practical purposes is as unworked now as it was in the days of Plato, is, in simple truth, ten times more important to humanity than all the chemistry and physics, all the technical and indsutrial science that ever has been or ever will be discovered.

Through the discovery of Buchner, Biology was relieved of another fragment of mysticism. The splitting up of sugar into CO₂ and alcohol is no more the effect of a 'vital principle' than the splitting up of cane sugar by invertase. The history of this problem is instructive, as it warns us against considering problems as beyond our reach because they have not yet found their solution.

To produce a really good biological theory one must try to see through the clutter produced by evolution to the basic mechanisms lying beneath them, realizing that they are likely to be overlaid by other, secondary mechanisms. What seems to physicists to be a hopelessly complicated process may have been what nature found simplest, because nature could only build on what was already there.

To-day, science has withdrawn into realms that are hardly understanded of the people. Biology means very largely histology, the study of the cell by difficult and elaborate microscopical processes. Chemistry has passed from the mixing of simple substances with ascertained reactions, to an experimentation of these processes under varying conditions of temperature, pressure, and electrification—all requiring complicated apparatus and the most delicate measurement and manipulation. Similarly, physics has outgrown the old formulas of gravity, magnetism, and pressure; has discarded the molecule and atom for the ion, and may in its recent generalizations be followed only by an expert in the higher, not to say the transcendental mathematics.

Until 1930 or thereabout biologists [using microscopes], in the situation of Astronomers and Astrophysicists, were permitted to see the objects of their interest, but not to touch them; the cell was as distant from us, as the stars and galaxies were from them.

We must [it has been arued] go beyond reductionism to a holistic recognition that biology and culture interpenetrate in an inextricable manner.

What politicians do not understand is that [Ian] Wilmut discovered not so much a technical trick as a new law of nature. We now know that an adult mammalian cell can fire up all the dormant genetic instructions that shut down as it divides and specializes and ages, and thus can become a source of new life. You can outlaw technique; you cannot repeal biology.
Writing after Wilmut's successful cloning of the sheep, Dolly, that research on the cloning of human beings cannot be suppressed.

[Science] is the literature of God written on the stars—the trees—the rocks—and more important because [of] its marked utilitarian character.