All things are artificial, for nature is the art of God.

Every chemical substance, whether natural or artificial, falls into one of two major categories, according to the spatial characteristic of its form. The distinction is between those substances that have a plane of symmetry and those that do not. The former belong to the mineral, the latter to the living world.

Half a century ago Oswald (1910) distinguished classicists and romanticists among the scientific investigators: the former being inclined to design schemes and to use consistently the deductions from working hypotheses; the latter being more fit for intuitive discoveries of functional relations between phenomena and therefore more able to open up new fields of study. Examples of both character types are Werner and Hutton. Werner was a real classicist. At the end of the eighteenth century he postulated the theory of “neptunism,” according to which all rocks including granites, were deposited in primeval seas. It was an artificial scheme, but, as a classification system, it worked quite satisfactorily at the time. Hutton, his contemporary and opponent, was more a romanticist. His concept of “plutonism” supposed continually recurrent circuits of matter, which like gigantic paddle wheels raise material from various depths of the earth and carry it off again. This is a very flexible system which opens the mind to accept the possible occurrence in the course of time of a great variety of interrelated plutonic and tectonic processes.

How did I discover saccharin? Well, it was partly by accident and partly by study. I had worked a long time on the compound radicals and substitution products of coal tar... One evening I was so interested in my laboratory that I forgot about my supper till quite late, and then rushed off for a meal without stopping to wash my hands. I sat down, broke a piece of bread, and put it to my lips. It tasted unspeakably sweet. I did not ask why it was so, probably because I thought it was some cake or sweetmeat. I rinsed my mouth with water, and dried my moustache with my napkin, when, to my surprise the napkin tasted sweeter than the bread. Then I was puzzled. I again raised my goblet, and, as fortune would have it, applied my mouth where my fingers had touched it before. The water seemed syrup. It flashed on me that I was the cause of the singular universal sweetness, and I accordingly tasted the end of my thumb, and found it surpassed any confectionery I had ever eaten. I saw the whole thing at once. I had discovered some coal tar substance which out-sugared sugar. I dropped my dinner, and ran back to the laboratory. There, in my excitement, I tasted the contents of every beaker and evaporating dish on the table.

Some months ago we discovered that certain light elements emit positrons under the action of alpha particles. Our latest experiments have shown a very striking fact: when an aluminium foil is irradiated on a polonium preparation [alpha ray emitter], the emission of positrons does not cease immediately when the active preparation is removed: the foil remains radioactive and the emission of radiation decays exponentially as for an ordinary radio-element. We observed the same phenomenon with boron and magnesium.
[Co-author with Irène Joliot-Curie. This one-page paper reported their discovery of artificial radioactivity for which they were awarded the 1935 Nobel Prize for Chemistry.]

The ends of scientific classification are best answered, when the objects are formed into groups respecting which a greater number of general propositions can be made, and those propositions more important, than could be made respecting any other groups into which the same things could be distributed. ... A classification thus formed is properly scientific or philosophical, and is commonly called a Natural, in contradistinction to a Technical or Artificial, classification or arrangement.

The progress of synthesis, or the building up of natural materials from their constituent elements, proceeds apace. Even some of the simpler albuminoids, a class of substances of great importance in the life process, have recently been artificially prepared. ... Innumerable entirely new compounds have been produced in the last century. The artificial dye-stuffs, prepared from materials occurring in coal-tar, make the natural colours blush. Saccharin, which is hundreds of times sweeter than sugar, is a purely artificial substance. New explosives, drugs, alloys, photographic substances, essences, scents, solvents, and detergents are being poured out in a continuous stream.

This investigation has yielded an unanticipated result that reaction of cyanic acid with ammonia gives urea, a noteworthy result in as much as it provides an example of the artificial production of an organic, indeed a so-called animal, substance from inorganic substances.
[The first report of the epoch-making discovery, that an organic compound can be produced from inorganic substances.]

[My] numberless observations... made on the Strata... [have] made me confident of their uniformity throughout this Country & [have] led me to conclude that the same regularity... will be found to extend to every part of the Globe for Nature has done nothing by piecemeal. [T]here is no inconsistency in her productions. [T]he Horse never becomes an Ass nor the Crab an Apple by any intermixture or artificial combination whatever[. N]or will the Oak ever degenerate into an Ash or an Ash into an Elm. [H]owever varied by Soil or Climate the species will still be distinct on this ground. [T]hen I argue that what is found here may be found elsewhere[.] When proper allowances are made for such irregularities as often occur and the proper situation and natural agreement is well understood I am satisfied there will be no more difficulty in ascertaining the true quality of the Strata and the place of its possition [sic] than there is now in finding the true Class and Character of Plants by the Linean [sic] System.