'[R]eductionism' is one of those things, like sin, that is only mentioned by people who are against it. To call oneself a reductionist will sound, in some circles, a bit like admitting to eating babies. But, just as nobody actually eats babies, so nobody is really a reductionist in any sense worth being against.

All appearances to the contrary, the only watchmaker in nature is the blind forces of physics, albeit deployed in very special way. A true watchmaker has foresight: he designs his cogs springs, and plans their interconnections, with a future purpose in his mind's eye. Natural selection, the blind, unconscious, automatic process which Darwin discovered, and which we now know is the explanation for the existence and apparently purposeful form of all life, has no purpose in mind. It has no mind and no mind's eye. It does not plan for the future. It has no vision, no foresight, no sight at all. If it can be said to play the role of watchmaker in nature, it is the blind watchmaker.

But, however many ways there may be of being alive, it is certain that there are vastly more ways of being dead, or rather not alive.

DNA neither cares nor knows. DNA just is. And we dance to its music.

Evolution has no long-term goal. There is no long-distance target, no final perfection to serve as a criterion for selection, although human vanity cherishes the absurd notion that our species is the final goal of evolution.

If you don't know anything about computers, just remember that they are machines that do exactly what you tell them but often surprise you in the result.

In true natural selection, if a body has what it takes to survive, its genes automatically survive because they are inside it. So the genes that survive tend to be, automatically, those genes that confer on bodies the qualities that assist them to survive.

Intelligent life on a planet comes of age when it first works out the reason its own existence.

It is grindingly, creakingly, crashingly obvious that, if Darwinism were really a theory of chance, it couldn't work. You don't need to be a mathematician or physicist to calculate that an eye or a haemoglobin molecule would take from here to infinity to self-assemble by sheer higgledy-piggledy luck. Far from being a difficulty peculiar to Darwinism, the astronomic improbability of eyes and knees, enzymes and elbow joints and all the other living wonders is precisely the problem that any theory of life must solve, and that Darwinism uniquely does solve. It solves it by breaking the improbability up into small, manageable parts, smearing out the luck needed, going round the back of Mount Improbable and crawling up the gentle slopes, inch by million-year inch. Only God would essay the mad task of leaping up the precipice in a single bound.

It is raining DNA outside. On the bank of the Oxford canal at the bottom of my garden is a large willow tree, and it is pumping downy seeds into the air. ... [spreading] DNA whose coded characters spell out specific instructions for building willow trees that will shed a new generation of downy seeds. … It is raining instructions out there; it's raining programs; it's raining tree-growing, fluff-spreading, algorithms. That is not a metaphor, it is the plain truth. It couldn't be any plainer if it were raining floppy discs.

Mutation is random; natural selection is the very opposite of random

Nature is not cruel, only pitilessly indifferent. This is one of the hardest lessons for humans to learn. We cannot admit that things might be neither good nor evil, neither cruel nor kind, but simply callous—indifferent to all suffering, lacking all purpose.

Reductionism is a dirty word, and a kind of 'holistier than thou' self-righteousness has become fashionable.

The messages that DNA molecules contain are all but eternal when seen against the time scale of individual lifetimes. The lifetimes of DNA messages (give or take a few mutations) are measured in units ranging from millions of years to hundreds of millions of years; or, in other words, ranging from 10,000 individual lifetimes to a trillion individual lifetimes. Each individual organism should be seen as a temporary vehicle, in which DNA messages spend a tiny fraction of their geological lifetimes.

The physicist's problem is the problem of ultimate origins and ultimate natural laws. The biologist's problem is the problem of complexity.

We animals are the most complicated things in the known universe.

We are going to die, and that makes us the lucky ones. Most people are never going to die because they are never going to be born. The potential people who could have been here in my place but who will in fact never see the light of day outnumber the sand grains of Arabia. Certainly those unborn ghosts include greater poets than Keats, scientists greater than Newton. We know this because the set of possible people allowed by our DNA so massively outnumbers the set of actual people. In the teeth of these stupefying odds it is you and I, in our ordinariness, that are here.

We are survival machines, robot vehicles blindly programmed to preserve the selfish molecules known as genes. This is a truth which still with astonishment.

[O]ur own existence once presented the greatest of all mysteries, but … it is a mystery no longer because it is solved. Darwin and Wallace solved it … I was surprised that so many people seemed not only unaware of the elegant and beautiful solution to this deepest of problems but, incredibly, in many cases actually unaware that there was a problem in the first place!

…a robust hero of a man, who actually lives up to the cliché, 'a big main in every sense of the word'. Like other big men he is loved by many, feared by some, and not over-preoccupied with the judgments of any.